Zobrazeno 1 - 10
of 78
pro vyhledávání: '"John S Reece-Hoyes"'
Autor:
Hao Zeng, Johnny Castillo-Cabrera, Mika Manser, Bo Lu, Zinger Yang, Vaik Strande, Damien Begue, Raffaella Zamponi, Shumei Qiu, Frederic Sigoillot, Qiong Wang, Alicia Lindeman, John S Reece-Hoyes, Carsten Russ, Debora Bonenfant, Xiaomo Jiang, Youzhen Wang, Feng Cong
Publikováno v:
eLife, Vol 8 (2019)
EGFR-mutant NSCLCs frequently respond to EGFR tyrosine kinase inhibitors (TKIs). However, the responses are not durable, and the magnitude of tumor regression is variable, suggesting the existence of genetic modifiers of EGFR dependency. Here, we app
Externí odkaz:
https://doaj.org/article/2f4c85fb4b8e4572b5af26dcb106d8f3
Autor:
Juan I Fuxman Bass, Carles Pons, Lucie Kozlowski, John S Reece‐Hoyes, Shaleen Shrestha, Amy D Holdorf, Akihiro Mori, Chad L Myers, Albertha JM Walhout
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 10, Pp 1-19 (2016)
Abstract Transcription factors (TFs) play a central role in controlling spatiotemporal gene expression and the response to environmental cues. A comprehensive understanding of gene regulation requires integrating physical protein–DNA interactions (
Externí odkaz:
https://doaj.org/article/a6b21d56d5cf41ec85dc315ca42fac2b
Autor:
Ewa Surdziel, Ieuan Clay, Florian Nigsch, Anke Thiemeyer, Cyril Allard, Gregory Hoffman, John S Reece-Hoyes, Tanushree Phadke, Romain Gambert, Caroline Gubser Keller, Marie-Gabrielle Ludwig, Birgit Baumgarten, Mathias Frederiksen, Dirk Schübeler, Klaus Seuwen, Tewis Bouwmeester, Barna D Fodor
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0183679 (2017)
Macrophages are key cell types of the innate immune system regulating host defense, inflammation, tissue homeostasis and cancer. Within this functional spectrum diverse and often opposing phenotypes are displayed which are dictated by environmental c
Externí odkaz:
https://doaj.org/article/ee373e8c093841f49ffecddc87bb7dda
Autor:
Rowena DeJesus, Francesca Moretti, Gregory McAllister, Zuncai Wang, Phil Bergman, Shanming Liu, Elizabeth Frias, John Alford, John S Reece-Hoyes, Alicia Lindeman, Jennifer Kelliher, Carsten Russ, Judith Knehr, Walter Carbone, Martin Beibel, Guglielmo Roma, Aylwin Ng, John A Tallarico, Jeffery A Porter, Ramnik J Xavier, Craig Mickanin, Leon O Murphy, Gregory R Hoffman, Beat Nyfeler
Publikováno v:
eLife, Vol 5 (2016)
SQSTM1 is an adaptor protein that integrates multiple cellular signaling pathways and whose expression is tightly regulated at the transcriptional and post-translational level. Here, we describe a forward genetic screening paradigm exploiting CRISPR-
Externí odkaz:
https://doaj.org/article/740ed0340cbe47708079afcf989db0dd
Autor:
Kamesh Narasimhan, Samuel A Lambert, Ally WH Yang, Jeremy Riddell, Sanie Mnaimneh, Hong Zheng, Mihai Albu, Hamed S Najafabadi, John S Reece-Hoyes, Juan I Fuxman Bass, Albertha JM Walhout, Matthew T Weirauch, Timothy R Hughes
Publikováno v:
eLife, Vol 4 (2015)
Caenorhabditis elegans is a powerful model for studying gene regulation, as it has a compact genome and a wealth of genomic tools. However, identification of regulatory elements has been limited, as DNA-binding motifs are known for only 71 of the est
Externí odkaz:
https://doaj.org/article/f5fb0c93967e4b798b4863e1ee5801aa
Autor:
Eugene Schuster, Joshua J McElwee, Jennifer M A Tullet, Ryan Doonan, Filip Matthijssens, John S Reece‐Hoyes, Ian A Hope, Jacques R Vanfleteren, Janet M Thornton, David Gems
Publikováno v:
Molecular Systems Biology, Vol 6, Iss 1, Pp n/a-n/a (2010)
Insulin/IGF‐1 signaling controls metabolism, stress resistance and aging in Caenorhabditis elegans by regulating the activity of the DAF‐16/FoxO transcription factor (TF). However, the function of DAF‐16 and the topology of the transcriptional
Externí odkaz:
https://doaj.org/article/b9eb08e657cd45f9974a10a8b7a962cb
Autor:
Fiona Elwood, John Alford, Carsten Russ, Christopher Acker, Audrey Gray, John S. Reece-Hoyes, Carlos G Sanchez, Sarah J. Luchansky, Christian Doherty, Lucas Craig, Gregory McAllister, Steven Paula, Ricardo E. Dolmetsch, Shaojian An, Cheng Song, Alicia Lindeman, Malini Varadarajan, Nadire Cochran, Manuela Polydoro, Ketthsy Capre, Gregory R. Hoffman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology
Aggregates of hyperphosphorylated tau protein are a pathological hallmark of more than 20 distinct neurodegenerative diseases, including Alzheimer’s disease, progressive supranuclear palsy, and frontotemporal dementia. While the exact mechanism of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a06bbe1da74cbde2af5f7fb1d3fc80e
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
https://doaj.org/article/a6974f96fa3e43eca73250a0892da4a2
Autor:
Carsten Russ, Adrian Salathe, Charles Y. Lin, John Alford, Mathias Frederiksen, Caroline Gubser Keller, Gabi Schutzius, Sajjeev Jagannathan, Sebastian Bergling, Dominic Hoepfner, Heinz Ruffner, Nicolas Mercado, Judith Knehr, Alexandra Aebi, John S. Reece-Hoyes, Guglielmo Roma, David Estoppey, Remi Terranova, Hadley E. Sheppard, Calla M. Olson, Tewis Bouwmeester, Tanner C. Beck, Susan Kirkland, Florian Nigsch, Christian Kolter, Felix Lohmann, Selma Z. Elsarrag
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
Nature Communications
Nature Communications
Resident adult epithelial stem cells maintain tissue homeostasis by balancing self-renewal and differentiation. The stem cell potential of human epidermal keratinocytes is retained in vitro but lost over time suggesting extrinsic and intrinsic regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c9ef08e8616e1ba4a2ab8d68197bb3
http://link.springer.com/article/10.1038/s41467-019-12559-x
http://link.springer.com/article/10.1038/s41467-019-12559-x
Autor:
Xinming Cai, Zinger Yang, John S. Reece-Hoyes, Edmund Harrington, John Alford, Tim Schuhmann, Luis Llamas, Rob Maher, Alicia Lindeman, Stephen M. Canham, Irina Alimov, Nadire Cochran, Carsten Russ, Suchithra Menon, Gregory R. Hoffman, Qiong Wang, John Concannon
Publikováno v:
Journal of Biological Chemistry. 294:3359-3366
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276c48c6e9a8f74f5d3be2581e7eed33
https://doi.org/10.1074/jbc.ra118.005103
https://doi.org/10.1074/jbc.ra118.005103
Autor:
Atanu Paul, Stefano Annunziato, Bo Lu, Tianliang Sun, Olivera Evrova, Lara Planas-Paz, Vanessa Orsini, Luigi M. Terracciano, Olga Charlat, Zinger Yang Loureiro, Lei Ji, Raffaella Zamponi, Frederic Sigoillot, Hong Lei, Alicia Lindeman, Carsten Russ, John S. Reece-Hoyes, Thomas B. Nicholson, Jan S. Tchorz, Feng Cong
Publikováno v:
Nature communications. 13(1)
The Hippo/YAP pathway controls cell proliferation through sensing physical and spatial organization of cells. How cell-cell contact is sensed by Hippo signaling is poorly understood. Here, we identified the cell adhesion molecule KIRREL1 as an upstre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44427e821727c484783475c7e3846fa
https://pubmed.ncbi.nlm.nih.gov/35177623
https://pubmed.ncbi.nlm.nih.gov/35177623