Zobrazeno 1 - 10
of 166
pro vyhledávání: '"John S Mort"'
Autor:
Peter J Roughley, John S Mort
Publikováno v:
Journal of Experimental Orthopaedics, Vol 1, Iss 1, Pp n/a-n/a (2014)
Abstract Aggrecan is a large proteoglycan bearing numerous chondroitin sulfate and keratan sulfate chains that endow articular cartilage with its ability to withstand compressive loads. It is present in the extracellular matrix in the form of proteog
Externí odkaz:
https://doaj.org/article/4074f6aa7b024f39a85be7a2e4f491ee
Publikováno v:
Frontiers in Physics, Vol 5 (2017)
Collagens form the fibrous component of the extracellular matrix in all multi-cellular animals. Collagen type I is the most abundant collagen present in skin, tendons, vasculature, as well as the organic portion of the calcified tissue of bone and te
Externí odkaz:
https://doaj.org/article/03334fee3f6a4d8abf2f56603ab8f0b3
Autor:
Iris Boraschi-Diaz, Dieter Brömme, Yotis A. Senis, Svetlana V. Komarova, Alexandra Mazharian, John S. Mort
Publikováno v:
Bone. 117
The major organic component of bone is collagen type I. Osteoclasts are terminally differentiated multinucleated cells of hematopoietic origin that are essential for physiological development of bone and teeth. We examined if osteoclast differentiati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20b7ab21dc2cab6788e7d5d6b9a6d4df
https://pubmed.ncbi.nlm.nih.gov/30217615
https://pubmed.ncbi.nlm.nih.gov/30217615
Publikováno v:
Arthritis & Rheumatology. 67:2691-2701
Objective Transforming growth factor α (TGFα) is increased in osteoarthritic (OA) cartilage in rats and humans and modifies chondrocyte phenotype. CCL2 is increased in OA cartilage and stimulates proteoglycan loss. This study was undertaken to test
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc4b4b2098eb8b147e07a0e9e1e69d7e
https://doi.org/10.1002/art.39255
https://doi.org/10.1002/art.39255
Autor:
Matthew R. McCann, Kim L. Beaucage, M.A. Pest, Meg P. Kamphuis, Frank Beier, A. Ratneswaran, Cheryle A. Séguin, Gurkeet Lalli, Garth B. Backler, Jimin Lee, Ziana Esmail, David W. Holdsworth, John S. Mort, Priya Patel, Michael Barbalinardo, S. Jeffrey Dixon
Publikováno v:
Arthritis & Rheumatology. 67:2164-2175
Objective High-frequency, low-amplitude whole-body vibration (WBV) is being used to treat a range of musculoskeletal disorders; however, there is surprisingly limited knowledge regarding its effect(s) on joint tissues. This study was undertaken to ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea78114a0057bda83df25b59a3f1160c
https://doi.org/10.1002/art.39154
https://doi.org/10.1002/art.39154
Publikováno v:
Frontiers in Physics, Vol 5 (2017)
Collagens form the fibrous component of the extracellular matrix in all multi-cellular animals. Collagen type I is the most abundant collagen present in skin, tendons, vasculature, as well as the organic portion of the calcified tissue of bone and te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db3d017b447e9847278ce0681ba1183
http://journal.frontiersin.org/article/10.3389/fphy.2017.00012/full
http://journal.frontiersin.org/article/10.3389/fphy.2017.00012/full
Publikováno v:
Osteoarthritis and cartilage. 25(12)
Develop a species-specific ELISA for a neo-epitope generated by cathepsin K cleavage of equine type II collagen to: (1) measure cartilage type II collagen degradation by cathepsin K in vitro, (2) identify cytokines that upregulate cathepsin K express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0587a79cb2394ae9f554949c2b9db58
https://pubmed.ncbi.nlm.nih.gov/28882751
https://pubmed.ncbi.nlm.nih.gov/28882751
Autor:
Somayyeh Fahiminiya, Francis H. Glorieux, John S. Mort, Jacek Majewski, Frank Rauch, Pierre Moffatt, Klaus Klaushofer, Hadil Al-Jallad, Paul Roschger
Publikováno v:
Journal of Bone and Mineral Research. 29:1805-1814
Mutations in PLS3 have been identified as a cause of bone fragility in children, but the bone phenotype associated with PLS3 mutations has not been reported in detail. PLS3 is located on the X chromosome and encodes the actin-binding protein plastin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d6f355553268b3f5b5999d4d6ee78a2
https://doi.org/10.1002/jbmr.2208
https://doi.org/10.1002/jbmr.2208
Publikováno v:
BBA Clinical
Background The chitinase-like protein, Chi3L1, is associated with increased fibrotic activity as well as inflammatory processes. The capacity of skin cells from systemic sclerosis (SSc) patients to produce Chi3L1, and the stimulation of its synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6b725e37023af8132024af8a2e606f0
http://europepmc.org/articles/PMC4633946
http://europepmc.org/articles/PMC4633946
Autor:
John S. Mort, Alexander Emmott
Publikováno v:
Protein Expression and Purification. 91:37-41
The proteolysis of collagen fibrils by cathepsin K is a hallmark of bone catabolism and tissue degeneration. The production of active recombinant cathepsin K is central for our ability to study the mechanisms by which these processes occur. Here we r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a36d8a7602919e64a060236e65964f
https://doi.org/10.1016/j.pep.2013.06.012
https://doi.org/10.1016/j.pep.2013.06.012