423 Single cell RNA sequencing reveals functionally validated signatures of cytotoxicity in anti-FRα CoStimulatory Antigen Receptor (CoStARTM) activated CD4+ T cells

Autor: Mark Dudley, Gray Kueberuwa, John S Bridgeman, Martina Sykorova, Leyuan Bao, Robert E Hawkins, Katrina Sherbina Baklan, Owen Moon, Jinzhou Yuan

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)

Externí odkaz: https://doaj.org/article/094bf09ba2824d2f89844cf2d61005e0

177 Treatment outcomes with unselected autologous tumor infiltrating lymphocytes in patients with checkpoint inhibition–refractory advanced cutaneous melanoma

Autor: Natalia Kirillova, Robert Hawkins, Gray Kueberuwa, Paul C Lorigan, Yizhou Jiang, Fiona C Thistlethwaite, Manon Pillai, Martine Thomas, John S Bridgeman, Ryan D Guest, Zachary J Roberts

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

Externí odkaz: https://doaj.org/article/484b249da0c542a8858fb606066fec68

Massively parallel interrogation and mining of natively paired human TCRαβ repertoires

Autor: John S. Bridgeman, Matthew J. Spindler, Michael A. Asensio, Adam S. Adler, Robert E. Hawkins, Everett Meyer, James M. Heather, Ayla Nelson, Mark Cobbold, Ellen K. Wagner, Natasha Oppermans, Robert C. Edgar, David S. Johnson, Yoong Wearn Lim

Publikováno v: Spindler, M J, Nelson, A L, Wagner, E K, Oppermans, N, Bridgeman, J S, Heather, J M, Adler, A S, Asensio, M A, Edgar, R C, Lim, Y W, Meyer, E H, Hawkins, R E, Cobbold, M & Johnson, D S 2020, ' Massively parallel interrogation and mining of natively paired human TCRαβ repertoires ', Nature biotechnology, vol. 38, no. 5, pp. 609-619 . https://doi.org/10.1038/s41587-020-0438-y
Nature biotechnology

T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies for viral infections and cancer. However, efficient identification of clinical candidate TCRs is complicated by the size and complexity of T cell repertoires

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a601f16445c9fed0da1a9240693afe9a
https://doi.org/10.1038/s41587-020-0438-y

198 Costimulatory antigen receptor (CoStAR): a novel platform that enhances the activity of tumor infiltrating lymphocytes (TILs)

Autor: Yong Ouyang, Clare Yarka, Michelle Mojadidi, Rubén Alvarez-Rodríguez, Bob Hawkins, John S. Bridgeman, Milena Kalaitsidou, Eric H. Gschweng, Gray Kueberuwa, Sujita Sukumaran

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundMajor limiting factors for cell therapy in solid tumors include clonal heterogeneity and the related lack of universally expressed tumor-specific antigens. As the only truly polyclonal cell product in advanced development, tumor infiltratin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfc23bb69d0ce71f118ba6d39f5d3a59
https://doaj.org/article/f1f01214846a4469a73a85a6e72bcd72

CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor

Autor: Andrew K. Sewell, Anzelika Rubina, Sian Llewellyn-Lacey, John S. Bridgeman, Hugo A. van den Berg, Kelly L. Miners, Ore Francis, Linda Wooldridge, James E. McLaren, Lea Knezevic, Mathew Clement, David K. Cole, Kristin Ladell, David A. Price, Tamsin Dockree

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Significance Sufficient immune coverage of the peptide universe within a finite host requires highly degenerate T cell receptors (TCRs). However, this inherent need for antigen cross-recognition is associated with a high risk of autoimmunity, which c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9c33b623f7e94f5b0fb4f9ffe0512f
http://europepmc.org/articles/PMC8307375