Zobrazeno 1 - 10 of 580 pro vyhledávání: '"John S, Lazo"'
1
Akademický článek
An acute respiratory distress syndrome drug development collaboration stimulated by the Virginia Drug Discovery Consortium
Autor: John S. Lazo, Ruben M.L. Colunga-Biancatelli, Pavel. A. Solopov, John D. Catravas
Publikováno v: SLAS Discovery, Vol 28, Iss 6, Pp 249-254 (2023)
The genesis of most older medicinal agents has generally been empirical. During the past one and a half centuries, at least in the Western countries, discovering and developing drugs has been primarily the domain of pharmaceutical companies largely b
Externí odkaz: https://doaj.org/article/12f59415c4b7418f9a3b2fd3ab9e7f03
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2
Akademický článek
High content screening miniaturization and single cell imaging of mature human feeder layer-free iPSC-derived neurons
Autor: Elizabeth R. Sharlow, Danielle C. Llaneza, William E. Grever, Garnett A. Mingledorff, Anna J. Mendelson, George S. Bloom, John S. Lazo
Publikováno v: SLAS Discovery, Vol 28, Iss 6, Pp 275-283 (2023)
Human induced pluripotent stem cell (iPSC)-derived neurons are being increasingly used for high content imaging and screening. However, iPSC-derived neuronal differentiation and maturation is time-intensive, often requiring >8 weeks. Unfortunately, t
Externí odkaz: https://doaj.org/article/d14cfbcac61844679a8e3bf159917758
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3
Akademický článek
Discovery of Benzisothiazolone Derivatives as Bifunctional Inhibitors of HIV-1 Reverse Transcriptase DNA Polymerase and Ribonuclease H Activities
Autor: Alondra Vázquez Rivera, Heather Donald, Mounia Alaoui-El-Azher, John J. Skoko, John S. Lazo, Michael A. Parniak, Paul A. Johnston, Nicolas Sluis-Cremer
Publikováno v: Biomolecules, Vol 14, Iss 7, p 819 (2024)
The ribonuclease H (RNase H) active site of HIV-1 reverse transcriptase (RT) is the only viral enzyme not targeted by approved antiretroviral drugs. Using a fluorescence-based in vitro assay, we screened 65,239 compounds at a final concentration of 1
Externí odkaz: https://doaj.org/article/f8e64f106e54456d83df7089a79fcab8
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6
Akademický článek
The hubris and humility of cancer pharmacology in the post immuno‐oncology era
Autor: John S. Lazo
Publikováno v: Pharmacology Research & Perspectives, Vol 7, Iss 6, Pp n/a-n/a (2019)
Abstract Cancer is a dreaded word, which has stimulated monumental efforts to discover and deliver effective cancer treatments for more than half a century. During the past two decades, our understanding of the molecular pathogenesis of cancer has in
Externí odkaz: https://doaj.org/article/07205dba2cac4265b5c38fce84609ce7
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7
Akademický článek
Credentialing and Pharmacologically Targeting PTP4A3 Phosphatase as a Molecular Target for Ovarian Cancer
Autor: John S. Lazo, Elizabeth R. Sharlow, Robert Cornelison, Duncan J. Hart, Danielle C. Llaneza, Anna J. Mendelson, Ettore J. Rastelli, Nikhil R. Tasker, Charles N. Landen, Peter Wipf
Publikováno v: Biomolecules, Vol 11, Iss 7, p 969 (2021)
High grade serous ovarian cancer (OvCa) frequently becomes drug resistant and often recurs. Consequently, new drug targets and therapies are needed. Bioinformatics-based studies uncovered a relationship between high Protein Tyrosine Phosphatase of Re
Externí odkaz: https://doaj.org/article/bd03bd9e93c14cfb8f63e736838dafd7
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