Zobrazeno 1 - 10
of 177
pro vyhledávání: '"John S, Klassen"'
Autor:
Chih-Lan Lin, Mirat Sojitra, Eric J. Carpenter, Ellen S. Hayhoe, Susmita Sarkar, Elizabeth A. Volker, Chao Wang, Duong T. Bui, Loretta Yang, John S. Klassen, Peng Wu, Matthew S. Macauley, Todd L. Lowary, Ratmir Derda
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cellular glycosylation is characterized by chemical complexity and heterogeneity, which is challenging to reproduce synthetically. Here we show chemoenzymatic synthesis on phage to produce a genetically-encoded liquid glycan array (LiGA) of
Externí odkaz:
https://doaj.org/article/da21baab0c17465c9c943d4e2e9add04
Autor:
Edward N. Schmidt, Dimitra Lamprinaki, Kelli A. McCord, Maju Joe, Mirat Sojitra, Ayk Waldow, Jasmine Nguyen, John Monyror, Elena N. Kitova, Fahima Mozaneh, Xue Yan Guo, Jaesoo Jung, Jhon R. Enterina, Gour C. Daskhan, Ling Han, Amanda R. Krysler, Christopher R. Cromwell, Basil P. Hubbard, Lori J. West, Marianne Kulka, Simonetta Sipione, John S. Klassen, Ratmir Derda, Todd L. Lowary, Lara K. Mahal, Meghan R. Riddell, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Immunomodulatory Siglecs are controlled by their glycoprotein and glycolipid ligands. Siglec-glycolipid interactions are often studied outside the context of a lipid bilayer, missing the complex behaviors of glycolipids in a membrane. Throug
Externí odkaz:
https://doaj.org/article/1b849c2f9a814c4e9507f12b5f5f0d43
Autor:
Andreea A. Gheorghita, Yancheng E. Li, Elena N. Kitova, Duong T. Bui, Roland Pfoh, Kristin E. Low, Gregory B. Whitfield, Marthe T. C. Walvoort, Qingju Zhang, Jeroen D. C. Codée, John S. Klassen, P. Lynne Howell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The pathogen Pseudomonas aeruginosa uses a synthase-dependent secretion system for production of the exopolysaccharide alginate, which is associated with lung infection severity. Here, Gheorghita et al. determine the crystal structure of one of the s
Externí odkaz:
https://doaj.org/article/699c5ef533fd41cbbb1e150d996bacbe
Autor:
Taylor J. B. Forrester, Olga G. Ovchinnikova, Zhixiong Li, Elena N. Kitova, Jeremy T. Nothof, Akihiko Koizumi, John S. Klassen, Todd L. Lowary, Chris Whitfield, Matthew S. Kimber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
WbbB is a structurally unusual retaining glycosyltransferase. Here, the authors show that WbbB forms an Asp232-Kdo adduct prior to transfer to the saccharide acceptor. Therefore, unlike any previously studied glycosyltransferase, WbbB uses the double
Externí odkaz:
https://doaj.org/article/2fa33b5bdb8243bf8c1fb3e07ccfe81c
Autor:
Roland Pfoh, Adithya S Subramanian, Jingjing Huang, Dustin J Little, Adam Forman, Benjamin R DiFrancesco, Negar Balouchestani-Asli, Elena N Kitova, John S Klassen, Régis Pomès, Mark Nitz, P Lynne Howell
Publikováno v:
PLoS Pathogens, Vol 18, Iss 8, p e1010750 (2022)
The synthesis of exopolysaccharides as biofilm matrix components by pathogens is a crucial factor for chronic infections and antibiotic resistance. Many periplasmic proteins involved in polymer processing and secretion in Gram-negative synthase depen
Externí odkaz:
https://doaj.org/article/a4e5e4ac72e544bdb741f717ccff0750
Autor:
Vasiliki Paraskevopoulou, Marianne Schimpl, Ross C. Overman, Snow Stolnik, Yajie Chen, Linh Nguyen, G. Sebastiaan Winkler, Paul Gellert, John S. Klassen, Franco H. Falcone
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 19-29 (2021)
Helicobacter pylori (H. pylori) uses several outer membrane proteins for adhering to its host's gastric mucosa, an important step in establishing and preserving colonization. Several adhesins (SabA, BabA, HopQ) have been characterized in terms of the
Externí odkaz:
https://doaj.org/article/8195fe10d9e7491586ad5fba6c9ba824
Autor:
Emily Rodrigues, Jaesoo Jung, Heajin Park, Caleb Loo, Sepideh Soukhtehzari, Elena N. Kitova, Fahima Mozaneh, Gour Daskhan, Edward N. Schmidt, Vivian Aghanya, Susmita Sarkar, Laura Streith, Chris D. St. Laurent, Linh Nguyen, Jean-Philippe Julien, Lori J. West, Karla C. Williams, John S. Klassen, Matthew S. Macauley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Sialic acid-binding immunoglobulin-type lectins (Siglecs) are a family of immunomodulatory receptors expressed on cells of the hematopoietic lineage. Here the authors demonstrate an approach for the identification of the glycan ligands of Siglecs, wh
Externí odkaz:
https://doaj.org/article/c0a8a14897d44e9db090036236f8b1ee
Autor:
Natalie C. Bamford, François Le Mauff, Jaime C. Van Loon, Hanna Ostapska, Brendan D. Snarr, Yongzhen Zhang, Elena N. Kitova, John S. Klassen, Jeroen D. C. Codée, Donald C. Sheppard, P. Lynne Howell
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a foundi
Externí odkaz:
https://doaj.org/article/bc12a17a65694000bd265c5f6442da5e
Autor:
Taylor J. B. Forrester, Olga G. Ovchinnikova, Zhixiong Li, Elena N. Kitova, Jeremy T. Nothof, Akihiko Koizumi, John S. Klassen, Todd L. Lowary, Chris Whitfield, Matthew S. Kimber
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/70513d97c9e147d892c0109832b3dc52
Autor:
Ilhan Tomris, Luca Unione, Linh Nguyen, Pouya Zaree, Kim M. Bouwman, Lin Liu, Zeshi Li, Jelle A. Fok, María Ríos Carrasco, Roosmarijn van der Woude, Anne L. M. Kimpel, Mirte W. Linthorst, Sinan E. Kilavuzoglu, Enrico C. J. M. Verpalen, Tom G. Caniels, Rogier W. Sanders, Balthasar A. Heesters, Roland J. Pieters, Jesús Jiménez-Barbero, John S. Klassen, Geert-Jan Boons, Robert P. de Vries
Publikováno v:
ACS chemical biology. American Chemical Society
SARS-CoV-2 viruses engage ACE2 as a functional receptor with their spike protein. The S1 domain of the spike protein contains a C-terminal receptor binding domain (RBD) and an N-terminal domain (NTD). The NTD of other coronaviruses includes a glycan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7986185a9b6e04f9b6d48ebf9be5cc9
https://doi.org/10.1021/acschembio.3c00066
https://doi.org/10.1021/acschembio.3c00066