Zobrazeno 1 - 10
of 40
pro vyhledávání: '"John S, Bridgeman"'
Autor:
Mark Dudley, Gray Kueberuwa, John S Bridgeman, Martina Sykorova, Leyuan Bao, Robert E Hawkins, Katrina Sherbina Baklan, Owen Moon, Jinzhou Yuan
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/094bf09ba2824d2f89844cf2d61005e0
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/7e2a3d2133bc42ef929ff49564420d77
Autor:
Milena Kalaitsidou, Owen R. Moon, Martina Sykorova, Leyuan Bao, Yun Qu, Sujita Sukumaran, Michael Valentine, Xingliang Zhou, Veethika Pandey, Kay Foos, Sergey Medvedev, Daniel J. Powell Jr, Akshata Udyavar, Eric Gschweng, Ruben Rodriguez, Mark E. Dudley, Robert E. Hawkins, Gray Kueberuwa, John S. Bridgeman
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Transfer of autologous tumor infiltrating lymphocytes (TIL) to patients with refractory melanoma has shown clinical efficacy in a number of trials. However, extending the clinical benefit to patients with other cancers poses a challenge. Inefficient
Externí odkaz:
https://doaj.org/article/7f1e15ebf5834e83a34fa2733d953fd0
Autor:
Natalia Kirillova, Robert Hawkins, Gray Kueberuwa, Paul C Lorigan, Yizhou Jiang, Fiona C Thistlethwaite, Manon Pillai, Martine Thomas, John S Bridgeman, Ryan D Guest, Zachary J Roberts
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/484b249da0c542a8858fb606066fec68
Publikováno v:
Therapeutic Advances in Vaccines and Immunotherapy, Vol 8 (2020)
With the advent of immunotherapy as a realistic and promising option for cancer treatment, adoptive cellular therapies are gaining significant interest in the clinic. Whilst the recent successes of chimeric antigen receptor T-cell therapies for haema
Externí odkaz:
https://doaj.org/article/be831200a6294f8c94d69b1397b6fb51
Autor:
Frances E Pearson, Kirsteen M Tullett, Ingrid M Leal‐Rojas, Oscar L Haigh, Kelly‐Anne Masterman, Carina Walpole, John S Bridgeman, James E McLaren, Kristin Ladell, Kelly Miners, Sian Llewellyn‐Lacey, David A Price, Antje Tunger, Marc Schmitz, John J Miles, Mireille H Lahoud, Kristen J Radford
Publikováno v:
Clinical & Translational Immunology, Vol 9, Iss 6, Pp n/a-n/a (2020)
Abstract Objectives Vaccines that prime Wilms' tumor 1 (WT1)‐specific CD8+ T cells are attractive cancer immunotherapies. However, immunogenicity and clinical response rates may be enhanced by delivering WT1 to CD141+ dendritic cells (DCs). The C
Externí odkaz:
https://doaj.org/article/d7716a6649ca41f9a6290ec9da9eae79
Autor:
David K. Cole, Anna Fuller, Garry Dolton, Efthalia Zervoudi, Mateusz Legut, Kim Miles, Lori Blanchfield, Florian Madura, Christopher J. Holland, Anna M. Bulek, John S. Bridgeman, John J. Miles, Andrea J. A. Schauenburg, Konrad Beck, Brian D. Evavold, Pierre J. Rizkallah, Andrew K. Sewell
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
Serial accumulation of mutations to fixation in the SLYNTVATL (SL9) immunodominant, HIV p17 Gag-derived, HLA A2-restricted cytotoxic T lymphocyte epitope produce the SLFNTIAVL triple mutant “ultimate” escape variant. These mutations in solvent-ex
Externí odkaz:
https://doaj.org/article/2e44b85e69cd4584a5aba4121bc60462
Autor:
John S. Bridgeman, Matthew J. Spindler, Michael A. Asensio, Adam S. Adler, Robert E. Hawkins, Everett Meyer, James M. Heather, Ayla Nelson, Mark Cobbold, Ellen K. Wagner, Natasha Oppermans, Robert C. Edgar, David S. Johnson, Yoong Wearn Lim
Publikováno v:
Spindler, M J, Nelson, A L, Wagner, E K, Oppermans, N, Bridgeman, J S, Heather, J M, Adler, A S, Asensio, M A, Edgar, R C, Lim, Y W, Meyer, E H, Hawkins, R E, Cobbold, M & Johnson, D S 2020, ' Massively parallel interrogation and mining of natively paired human TCRαβ repertoires ', Nature biotechnology, vol. 38, no. 5, pp. 609-619 . https://doi.org/10.1038/s41587-020-0438-y
Nature biotechnology
Nature biotechnology
T cells engineered to express antigen-specific T cell receptors (TCRs) are potent therapies for viral infections and cancer. However, efficient identification of clinical candidate TCRs is complicated by the size and complexity of T cell repertoires
Autor:
Milena Kalaitsidou, Rubén Alvarez-Rodríguez, Leyuan Bao, Michelle Le Brocq, John S. Bridgeman, Gray Kueberuwa, Robert E. Hawkins, Martina Sykorova, Cynthia Chauvin-Fleurence
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCostimulatory signals are a critical component to mount an effective anti-tumor response. Prolonged TCR stimulation in the absence of costimulatory signals can lead to T cell anergy and dysfunction. The tumor microenvironment evades immune
Autor:
Yong Ouyang, Clare Yarka, Michelle Mojadidi, Rubén Alvarez-Rodríguez, Bob Hawkins, John S. Bridgeman, Milena Kalaitsidou, Eric H. Gschweng, Gray Kueberuwa, Sujita Sukumaran
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundMajor limiting factors for cell therapy in solid tumors include clonal heterogeneity and the related lack of universally expressed tumor-specific antigens. As the only truly polyclonal cell product in advanced development, tumor infiltratin