Zobrazeno 1 - 10
of 21
pro vyhledávání: '"John Roque"'
Autor:
Sarah Chamberlain, Houston D. Cole, John Roque, David Bellnier, Sherri A. McFarland, Gal Shafirstein
Publikováno v:
Pharmaceuticals, Vol 13, Iss 7, p 137 (2020)
Intra-operative photodynamic therapy (IO-PDT) in combination with surgery for the treatment of non-small cell lung cancer and malignant pleural mesothelioma has shown promise in improving overall survival in patients. Here, we developed a PDT platfor
Externí odkaz:
https://doaj.org/article/4a0dfcef42294335ba5359d4e9fc7168
Autor:
Kilian R. A. Schneider, John Roque, Sherri A. McFarland, Colin G. Cameron, Houston D. Cole, Benjamin Dietzek, Avinash Chettri
Publikováno v:
J Phys Chem A
We explore the photophysical properties of a family of Ru(II) complexes, Ru-ip-nT, designed as photosensitizers for photodynamic therapy (PDT). The complexes incorporate a 1H-imidazo[4,5-f][1,10]-phenanthroline (ip) ligand appended to one or more thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15599bf517225a80e136921b4d16ae5a
https://doi.org/10.1021/acs.jpca.1c04900
https://doi.org/10.1021/acs.jpca.1c04900
Autor:
Sherri A. McFarland, Houston D. Cole, John Roque, Kilian R. A. Schneider, Benjamin Dietzek, Colin G. Cameron, Avinash Chettri
Publikováno v:
ChemPhotoChem
TLD1433 is the first Ru(II) complex to be tested as a photodynamic therapy agent in a clinical trial. In this contribution we study TLD1433 in the context of structurally-related Ru(II)-imidozo[4,5-f][1,10]phenanthroline (ip) complexes appended with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84fec459eb8f8056a27025dba027d0ce
https://doi.org/10.1002/cptc.202000283
https://doi.org/10.1002/cptc.202000283
Autor:
Christoffer Lagerholm, Katharina Reglinski, Kilian R. A. Schneider, Benjamin Dietzek, Christian Eggeling, John Roque, Peter Bäuerle, Sylvia Schmid, Colin G. Cameron, Sherri A. McFarland, Anne Stumper, Avinash Chettri, Djawed Nauroozi, Sven Rau, Houston D. Cole, Jannik Brückmann
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
Intracellular excited-state properties of a photodynamic active Osmium-complex are investigated. The key to the excited-state relaxation is the interplay of 3MLCT and 3ILCT states on the oligothiophene-substituted ligand. We successfully tested the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19cfae4c82949791cfd8f50c26d59aab
http://europepmc.org/articles/PMC7704931
http://europepmc.org/articles/PMC7704931
Autor:
Colin G. Cameron, Liubov M. Lifshits, Sherri A. McFarland, John Roque, Houston D. Cole, Randolph P. Thummel
Publikováno v:
Chembiochem
The design of near-infrared (NIR)-active photosensitizers (PSs) for light-based cancer treatments such as photodynamic therapy (PDT) has been a challenge. While several NIR-Ru(II) scaffolds have been reported, this approach has not been proven in cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d61bf99ab3d4597b8123d3cfe75815
https://doi.org/10.1002/cbic.202000419
https://doi.org/10.1002/cbic.202000419
Autor:
Julia McCain, William T. Sparks, Dmytro Havrylyuk, Colin G. Cameron, John Roque, Susan Monro, Sherri A. McFarland, Katsuya L. Colón, Tariq Sainuddin, Edith C. Glazer, Patrick C. Barrett, Evan Bradner, David K. Heidary
Publikováno v:
Photochem Photobiol
A series of strained Ru(II) complexes were studied for potential anticancer activity in hypoxic tissues. The complexes were constructed with methylated ligands that were photolabile and an imidizo[4,5-f][1,10]phenanthroline ligand that contained an a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deab848e75bcfd0fdcc3e5102e89b6af
https://doi.org/10.1111/php.13174
https://doi.org/10.1111/php.13174
Autor:
Sherri A. McFarland, S.D. Kim, Houston D. Cole, Susan Monro, Randolph P. Thummel, Prathyusha Konda, Colin G. Cameron, Shashi Gujar, Gagan Deep, John Roque, Liubov M. Lifshits, David von Dohlen
Publikováno v:
Chemical Science
Mounting evidence over the past 20 years suggests that photodynamic therapy (PDT), an anticancer modality known mostly as a local treatment, has the capacity to invoke a systemic antitumor immune response, leading to protection against tumor recurren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28134ca36bb4489c5ba2d3e3a8a0329c
https://doi.org/10.1039/d0sc03875j
https://doi.org/10.1039/d0sc03875j
Autor:
Huimin Yin, Susan Monro, John Roque, Colin G. Cameron, Deborah A. Smithen, Alison Thompson, Roberto M. Diaz-Rodriguez, Mitch Pinto, Sherri A. McFarland
Publikováno v:
Chemical Science. 11:12047-12069
A new family of ten dinuclear Ru(II) complexes based on the bis[pyrrolyl Ru(II)] triad scaffold, where two Ru(bpy)2 centers are separated by a variety of organic linkers, was prepared to evaluate the influence of the organic chromophore on the spectr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80918f12d9bd24fbbba18e9e7ba6f03f
https://doi.org/10.1039/d0sc04500d
https://doi.org/10.1039/d0sc04500d
Autor:
Gagan Deep, John Roque, S.D. Kim, Susan Monro, Colin G. Cameron, Marta E. Alberto, David von Dohlen, Liubov M. Lifshits, Nino Russo, Ge Shi, Houston D. Cole, Sherri A. McFarland, Patrick C. Barrett
Publikováno v:
Chemical Science. 11:9784-9806
Hypoxia presents a two-fold challenge in the treatment of cancer, as low oxygen conditions induce biological changes that make malignant tissues simultaneously more aggressive and less susceptible to standard chemotherapy. This paper reports the firs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17c139a17049d56831c024f85a72a5e1
https://doi.org/10.1039/d0sc03008b
https://doi.org/10.1039/d0sc03008b
Ruthenium Photosensitizers for NIR PDT Require Lowest-Lying Triplet Intraligand (3IL) Excited States
Autor:
Randolph P. Thummel, Sherri A. McFarland, Colin G. Cameron, Elamparuthi Ramasamy, John Roque, Liubov M. Lifshits
Publikováno v:
Journal of Photochemistry and Photobiology, Vol 8, Iss, Pp 100067-(2021)
J Photochem Photobiol
J Photochem Photobiol
A family of complexes of the type [Ru(tpbn)(IP-R)(4-pic)]Cl(2) (tbpn=2,2′-(4-(tert-butyl)pyridine-2,6-diyl)bis(1,8-napthyridine); 4-pic=4-picoline; IP-R=imidazo[4,5-f][1,10]phenanthroline attached to an aromatic group R for 2–8 and H for 1) were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b0a38504cc0aae66ef12f02ffcc1e3
http://www.sciencedirect.com/science/article/pii/S266646902100052X
http://www.sciencedirect.com/science/article/pii/S266646902100052X