Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John Robert Adair"'
Publikováno v:
Expert Opinion on Investigational Drugs. 8:211-227
The production of recombinant proteins in plants is reviewed with a particular focus on plant-derived vaccines and antibodies for human healthcare. Issues relating to foreign gene expression, such as protein yield, localisation and glycosylation are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3514f5cc5a92610d516c12692c8d577
https://doi.org/10.1517/13543784.8.3.211
https://doi.org/10.1517/13543784.8.3.211
Publikováno v:
Expert Opinion on Investigational Drugs. 4:863-870
(1995). Monthly Update: Biologicals & Immunologicals: Progress with humanised antibodies - An update. Expert Opinion on Investigational Drugs: Vol. 4, No. 9, pp. 863-870.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bceed83706e313275ed6437b9c9e1b6
https://doi.org/10.1517/13543784.4.9.863
https://doi.org/10.1517/13543784.4.9.863
Autor:
Geoffrey Yarranton, David J. King, Nigel Richard Whittle, Andrew Millican, John Robert Adair, Raymond J. Owens, Alan Howard Lyons
Publikováno v:
"Protein Engineering, Design and Selection". 3:703-708
Many diagnostic and therapeutic applications of monoclonal antibodies require the covalent linking of effector or reporter molecules to the immunoglobulin polypeptides. Existing methods generally involve the non-selective modification of amino acid s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3de52df3f365445b0b7429374151a7
https://doi.org/10.1093/protein/3.8.703
https://doi.org/10.1093/protein/3.8.703
Autor:
M. R. Rolfe, John Robert Adair, D. J. King, Raymond J. Owens, H. M. Caskey-Finney, Andrew Mountain, M. Sehdev, T. S. Baker, C. C. Bose, Alan Howard Lyons, Alastair D. G. Lawson, G. T. Yarranton
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461360384
Antibody-drug conjugates utilize the targetting potential of antibodies to improve the potential of cytostatic or cytocidal drugs. One such murine monoclonal antibody, CTM01 (mCTM0l), which recognizes an epitope on breast epithelial mucin, has potent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c06ce4900bf08093018381e5f38de67
https://doi.org/10.1007/978-1-4615-2443-4_8
https://doi.org/10.1007/978-1-4615-2443-4_8
A single amino acid substitution abolishes the heterogeneity of chimeric mouse/human (IgG4) antibody
Autor:
John Robert Adair, B. Pedley, Sarojani Angal, Mark Bodmer, David J. King, A. Turner, Alastair David Griffiths Lawson, G. Roberts
Publikováno v:
Molecular immunology. 30(1)
Human immunoglobulin G4 (IgG4) exists in two molecular forms due to the heterogeneity of the inter-heavy chain disulphide bridges in the hinge region in a proportion of secreted human IgG4. This heterogeneity is only revealed under denaturing, non-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672061cd951de1b43bfd2af2e315f813
https://pubmed.ncbi.nlm.nih.gov/8417368
https://pubmed.ncbi.nlm.nih.gov/8417368
Autor:
D C Low, John Robert Adair, Geoffrey Yarranton, Sarojani Angal, K A Proudfoot, J. C. Lloyd, David J. King, Mark Bodmer
Publikováno v:
The Biochemical journal. 281
B72.3 is a mouse monoclonal antibody against a tumour-associated antigen, TAG72, which recognizes breast, ovarian and colorectal tumour tissue. A mouse-human chimeric version of B72.3 has been expressed in Chinese-hamster ovary cells. This molecule h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39627e3bda81d8fc4bba9fc688a3c917
https://pubmed.ncbi.nlm.nih.gov/1736881
https://pubmed.ncbi.nlm.nih.gov/1736881
Publikováno v:
Immunology today. 12(4)
Access to a wide range of high quality and increasingly sophisticated reagents and equipment has underpinned the great surge of knowledge in basic immunology and the growing interest in clinical immunointervention. In this article, the first in an oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9d64f018970219084681f16e4daa89b
https://pubmed.ncbi.nlm.nih.gov/2059313
https://pubmed.ncbi.nlm.nih.gov/2059313
Autor:
D. J. King, G. T. Yarranton, P. Antoniw, A. Turner, Alan Howard Lyons, S. Welt, Helene Margaret Finney, D. Shochat, Raymond J. Owens, Alastair D. G. Lawson, A P Farnsworth, L. J. Old, A. M. R. Haines, John Robert Adair
Publikováno v:
Journal of Immunotherapy. 16:156
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::375be179cbf76dc8e2a86cef6c3aa647
https://doi.org/10.1097/00002371-199408000-00040
https://doi.org/10.1097/00002371-199408000-00040
Autor:
David Colcher, Mark Bodmer, Liz Jenkins, John Robert Adair, Andrew Raubitschek, Jeffrey Schlom, Nigel Richard Whittle, Joan Devine, Chris Lloyd
Publikováno v:
"Protein Engineering, Design and Selection". 1:499-505
B72.3 is a mouse hybridoma cell-line secreting an IgG1 antibody which recognises an epitope on a tumour-associated antigen, TAG-72. This high molecular weight mucin-like molecule is found on a variety of human neoplasms, including colon, breast and o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bdefd40f2fa8da01f3f928ff2cbed7b
https://doi.org/10.1093/protein/1.6.499
https://doi.org/10.1093/protein/1.6.499