Zobrazeno 1 - 10
of 13
pro vyhledávání: '"John Reveille"'
Autor:
Mark Hwang, Shervin Assassi, Jim Zheng, Jessica Castillo, Reyna Chavez, Kamala Vanarsa, Chandra Mohan, John Reveille
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-10 (2023)
Abstract Background We sought to discover serum biomarkers of ankylosing spondylitis (AS) for diagnosis and monitoring disease activity. Methods We studied biologic-treatment-naïve AS and healthy control (HC) patients’ sera. Eighty samples matched
Externí odkaz:
https://doaj.org/article/7a500f80967d405c989c3e4c475c3459
Autor:
Joanne M. Hildebrand, Maria Kauppi, Ian J. Majewski, Zikou Liu, Allison J. Cox, Sanae Miyake, Emma J. Petrie, Michael A. Silk, Zhixiu Li, Maria C. Tanzer, Gabriela Brumatti, Samuel N. Young, Cathrine Hall, Sarah E. Garnish, Jason Corbin, Michael D. Stutz, Ladina Di Rago, Pradnya Gangatirkar, Emma C. Josefsson, Kristin Rigbye, Holly Anderton, James A. Rickard, Anne Tripaydonis, Julie Sheridan, Thomas S. Scerri, Victoria E. Jackson, Peter E. Czabotar, Jian-Guo Zhang, Leila Varghese, Cody C. Allison, Marc Pellegrini, Gillian M. Tannahill, Esme C. Hatchell, Tracy A. Willson, Dina Stockwell, Carolyn A. de Graaf, Janelle Collinge, Adrienne Hilton, Natasha Silke, Sukhdeep K. Spall, Diep Chau, Vicki Athanasopoulos, Donald Metcalf, Ronald M. Laxer, Alexander G. Bassuk, Benjamin W. Darbro, Maria A. Fiatarone Singh, Nicole Vlahovich, David Hughes, Maria Kozlovskaia, David B. Ascher, Klaus Warnatz, Nils Venhoff, Jens Thiel, Christine Biben, Stefan Blum, John Reveille, Michael S. Hildebrand, Carola G. Vinuesa, Pamela McCombe, Matthew A. Brown, Benjamin T. Kile, Catriona McLean, Melanie Bahlo, Seth L. Masters, Hiroyasu Nakano, Polly J. Ferguson, James M. Murphy, Warren S. Alexander, John Silke
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Necroptosis is a regulated form of inflammatory cell death driven by activated MLKL. Here, the authors identify a mutation in the brace region that confers constitutive activation, leading to lethal inflammation in homozygous mutant mice and providin
Externí odkaz:
https://doaj.org/article/eb684694de314067aac5b53c9a7c86cd
Publikováno v:
Rheumatic Disease Clinics of North America. 48:813-826
Spondyloarthropathies, also known as spondyloarthritis, encompasses a spectrum of diseases classified by it's axial and peripheral musculoskeletal manifestations. Extra-articular features are common in SpA making these systemic rheumatologic diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e433816cdc9c531d3c7eee9dc7d9f3f2
https://doi.org/10.1016/j.rdc.2022.06.004
https://doi.org/10.1016/j.rdc.2022.06.004
Autor:
Cody C. Allison, Benjamin T. Kile, Esme C. Hatchell, Maria Kozlovskaia, Catriona McLean, Pradnya Gangatirkar, Gabriela Brumatti, Marc Pellegrini, Pamela A. McCombe, Julie Sheridan, Donald Metcalf, Klaus Warnatz, Natasha Silke, Maria C. Tanzer, Janelle E. Collinge, Seth L. Masters, Victoria E. Jackson, Jason Corbin, David B. Ascher, Dina Stockwell, Nicole Vlahovich, Zhixiu Li, James M. Murphy, Carola G. Vinuesa, Maria Kauppi, Ronald M. Laxer, John Reveille, Adrienne A. Hilton, John Silke, Ian J. Majewski, David Hughes, Gillian M. Tannahill, Melanie Bahlo, Christine Biben, Michael A. Silk, Maria A. Fiatarone Singh, Cathrine Hall, Peter E. Czabotar, Jian-Guo Zhang, Polly J. Ferguson, Sukhdeep K Spall, Carolyn A. de Graaf, Michael D. Stutz, Nils Venhoff, Alexander G. Bassuk, Zikou Liu, Holly Anderton, Michael S. Hildebrand, Tracy A. Willson, James A Rickard, Hiroyasu Nakano, Vicki Athanasopoulos, Matthew A. Brown, Samuel N. Young, Jens Thiel, Emma J. Petrie, Diep Chau, Sarah E Garnish, Sanae Miyake, Anne Tripaydonis, Warren S. Alexander, Allison Cox, Stefan Blum, Joanne M Hildebrand, Thomas S. Scerri, Kristin A Rigbye, Leila N. Varghese, Benjamin W. Darbro, Emma C. Josefsson, Ladina Di Rago
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
NATURE COMMUNICATIONS
Nature Communications
NATURE COMMUNICATIONS
MLKL is the essential effector of necroptosis, a form of programmed lytic cell death. We have isolated a mouse strain with a single missense mutation, MlklD139V, that alters the two-helix ‘brace’ that connects the killer four-helix bundle and reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ead403f9f5ff09d2fd122f72a19f707f
http://link.springer.com/article/10.1038/s41467-020-16819-z
http://link.springer.com/article/10.1038/s41467-020-16819-z
Autor:
Matthew Stoll, Kimberly DeQuattro, Zhixiu Li, Henna Sawhney, Pamela Weiss, Peter Nigrovic, Tracey Wright, Kenneth Schikler, Barbara Edelheit, Casey Morrow, John Reveille, Matthew Brown, Lianne Gensler
Publikováno v:
Children; Volume 9; Issue 4; Pages: 569
Multiple studies have shown the microbiota to be abnormal in patients with spondyloarthritis (SpA). The purpose of this study was to explore the genetic contributions of these microbiota abnormalities. We analyzed the impact of HLA-B27 on the microbi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef692674edb4da2c353a82e4b9a9bf4
https://doi.org/10.3390/children9040569
https://doi.org/10.3390/children9040569
Autor:
Cody C. Allison, Pradnya Gangatirkar, Natasha Silke, Maria A. Fiatarone Singh, Alexander G. Bassuk, Joanne M Hildebrand, Julie Sheridan, Janelle E. Collinge, Matthew A. Brown, Nicole Vlahovich, Melanie Bahlo, Warren S. Alexander, Peter A. Czabotar, Thomas S. Scerri, Zikou Liu, Michael S. Hildebrand, James M. Murphy, Sukhdeep K Spall, Ronald M. Laxer, Cathrine Hall, Holly Anderton, Esme C. Hatchell, Maria Kozlovskaia, Adrienne A. Hilton, Maria C. Tanzer, Emma J. Petrie, Hiroyasu Nakano, Vicki Athanasopoulos, Klaus Warnatz, Michael A. Silk, Jens Thiel, James A Rickard, Pamela A. McCombe, John Reveille, Tracy A. Willson, Emma C. Josefsson, Gillian M. Tannahill, Stefan Blum, Jason Corbin, Zhixiu Li, Nils Venhoff, Catriona McLean, Sarah E Garnish, Dina Stockwell, Sanae Miyake, Anne Tripaydonis, Polly J. Ferguson, Allison Cox, John Silke, David Hughes, Jian-Guo Zhang, Michael D. Stutz, Samuel N. Young, Carolyn A. de Graaf, Marc Pellegrini, Diep Chau, Donald Metcalf, Ian J. Majewski, Carola G. Vinuesa, David B. Ascher, Maria Kauppi, Seth L. Masters, Ben T. Kile, Kristin A Rigbye, Benjamin W. Darbro
SUMMARYWe have isolated a mouse strain with a single missense mutation in the gene encoding MLKL, the essential effector of necroptotic cell death. The resulting substitution lies within the two-helix ‘brace’ and confers constitutive, RIPK3 indep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a37a517e02a47fb22c931fa0867867
Autor:
Weifeng, Ding, Weilin, Pu, Lei, Wang, Shuai, Jiang, Xiaodong, Zhou, Wenzhen, Tu, Ling, Yu, Jiaqian, Zhang, Shicheng, Guo, Qingmei, Liu, Yanyun, Ma, Sidi, Chen, Wenyu, Wu, John, Reveille, Hejian, Zou, Li, Jin, Jiucun, Wang
Publikováno v:
The Journal of investigative dermatology. 138(5)
Epigenetic modifications, including DNA methylation, play an important role in the pathogenesis of autoimmune diseases. In this study, we characterized the DNA methylome in primary T cells of patients with systemic sclerosis. Genome-wide DNA methylat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d8cf2991f2acbba2238d00ee105c736
https://pubmed.ncbi.nlm.nih.gov/29248544
https://pubmed.ncbi.nlm.nih.gov/29248544
Autor:
Matthew A. Brown, John Reveille
In addition to sharing clinical, histopathological, and immunological features, spondyloarthritis (SpA) encompasses a group of diseases that are genetically linked through shared associations with HLA-B27, as well as other genes of the IL-23R and ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::774cfcc112522f493acdf2f157de90e2
https://doi.org/10.1093/med/9780198734444.003.0005
https://doi.org/10.1093/med/9780198734444.003.0005
Autor:
Gang Peng, Li Luo, Hloicheong Siu, Yun Zhu, Pengfei Hu, Shengjun Hong, Jinying Zhao, Xiaodong Zhou, John Reveille, Li Jin, Christopher Amos, Momiao Xiong
Publikováno v:
Nature Precedings
Despite great success of GWAS in identification of common genetic variants associated with complex diseases, the current GWAS have focused on single SNP analysis. However, single SNP analysis often identifies a number of the most significant SNPs tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f74f646bfe66c49621f26da64e38916
https://doi.org/10.1038/npre.2008.2068.1
https://doi.org/10.1038/npre.2008.2068.1
Autor:
Ola, Khorshid, Chitra, Hosing, Samer, Bibawi, Naoto, Ueno, John, Reveille, Maureen D, Mayes, Richard E, Champlin
Publikováno v:
The Journal of rheumatology. 31(12)
Systemic sclerosis (SSc) is an uncommon connective tissue disease characterized by excessive collagen deposition within the skin and internal organs. Most patients with diffuse severe SSc are treated with immunosuppressive agents, but patients with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1efad39e9136aa59bdaac4afc4ec7867
https://pubmed.ncbi.nlm.nih.gov/15570631
https://pubmed.ncbi.nlm.nih.gov/15570631