Monoallelic chromatin conformation flanking long-range silenced domains in cancer-derived and normal cells.

Autor: Domenic Di Paola, John Raelson, Emmanouil Rampakakis, Mark Basik, Maria Zannis-Hadjopoulos, W Edward C Bradley

Publikováno v: PLoS ONE, Vol 8, Iss 5, p e63190 (2013)

Epigenetic inactivation of chromatin plays an important role in determining cell phenotype in both normal and cancer cells, but our knowledge is still incomplete with respect to any potential monoallelic nature of the phenomenon. We have genotyped DN

Externí odkaz: https://doaj.org/article/8b7ba499630743e48bc36cb44fa63130

Validating genetic markers of response to recombinant human growth hormone in children with growth hormone deficiency and Turner syndrome: the PREDICT validation study

Autor: Adam Stevens, Philip Murray, Jerome Wojcik, John Raelson, Ekaterina Koledova, Pierre Chatelain, Peter Clayton

Publikováno v: European Journal of Endocrinology
Stevens, F, Murray, P, Wojcik, J, Raelson, J, Koledova, E, Chatelain, P & Clayton, P 2016, ' Validating genetic markers of response to recombinant human growth hormone (r-hGH) in children with growth hormone deficiency (GHD) and Turner Syndrome (TS): The PREDICT Validation study ', European Journal of Endocrinology . https://doi.org/10.1530/EJE-16-0357

Objective Single-nucleotide polymorphisms (SNPs) associated with the response to recombinant human growth hormone (r-hGH) have previously been identified in growth hormone deficiency (GHD) and Turner syndrome (TS) children in the PREDICT long-term fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7382d0ed09d5a1b29dec740cc57176b8
https://pubmed.ncbi.nlm.nih.gov/27651465

Using Single Nucleotide Polymorphisms (SNPs) To Predict Year 1 and Year 2 Growth Response to Growth Hormone (GH) Therapy in Children with GH Deficiency (GHD) and Turner Syndrome (TS)

Autor: Peter Clayton, Pierre Chatelain, Elena Bashnina, Jia-Woei Hou, Cheri Deal, Sylvie Cabrol, Benoit Destenaves, John Raelson, Pascal Croteau, Sylvain Larroque, Clement Olivier

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34e6bfc38242d20d95888b98c48f65db
https://doi.org/10.1210/endo-meetings.2011.part2.p19.p1-736

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia

Autor: Ilya, Chumakov, Marta, Blumenfeld, Oxana, Guerassimenko, Laurent, Cavarec, Marta, Palicio, Hadi, Abderrahim, Lydie, Bougueleret, Caroline, Barry, Hiroaki, Tanaka, Philippe, La Rosa, Anne, Puech, Nadia, Tahri, Annick, Cohen-Akenine, Sylvain, Delabrosse, Sébastien, Lissarrague, Françoise-Pascaline, Picard, Karelle, Maurice, Laurent, Essioux, Philippe, Millasseau, Pascale, Grel, Virginie, Debailleul, Anne-Marie, Simon, Dominique, Caterina, Isabelle, Dufaure, Kattayoun, Malekzadeh, Maria, Belova, Jian-Jian, Luan, Michel, Bouillot, Jean-Luc, Sambucy, Gwenael, Primas, Martial, Saumier, Nadia, Boubkiri, Sandrine, Martin-Saumier, Myriam, Nasroune, Hélène, Peixoto, Arnaud, Delaye, Virginie, Pinchot, Mariam, Bastucci, Sophie, Guillou, Magali, Chevillon, Ricardo, Sainz-Fuertes, Said, Meguenni, Joan, Aurich-Costa, Dorra, Cherif, Anne, Gimalac, Cornelia, Van Duijn, Denis, Gauvreau, Gail, Ouellette, Isabel, Fortier, John, Raelson, Tatiana, Sherbatich, Nadejda, Riazanskaia, Evgeny, Rogaev, Peter, Raeymaekers, Jeroen, Aerssens, Frank, Konings, Walter, Luyten, Fabio, Macciardi, Pak C, Sham, Richard E, Straub, Daniel R, Weinberger, Nadine, Cohen, Daniel, Cohen, Gail, Ouelette, John, Realson

Publikováno v: Proceedings of the National Academy of Sciences of the U.S.A., 99, 13675-13680. National Academy of Sciences

A map of 191 single-nucleotide polymorphism (SNPs) was built across a 5-Mb segment from chromosome 13q34 that has been genetically linked to schizophrenia. DNA from 213 schizophrenic patients and 241 normal individuals from Canada were genotyped with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83667f3c76d9cca850cd3d8b7c5233ee
https://pure.eur.nl/en/publications/0848e3a4-4a47-4286-aca4-f79574228a30

OR11,61 Genetic markers associated with 1 month change in IGF-I and growth at 1 year during GH therapy in children with GH deficiency: The PREDICT study and follow-up highlight genetic contributions to individual response

Autor: L. Hagenas, P. Chatelain, T. Theocharis, S. Schnieper-Samec, M.D. Rodríguez-Arnao, N. Malo, L. Tato, Peter E. Clayton, John Raelson, C. Olivier, H.-W. Yoo

Publikováno v: Growth Hormone & IGF Research. 20:S28

patients who fit the height and IGF-I criteria of severe primary IGFD, i.e. both height and IGF-I standard deviation scores (SDS) ≤−3 with normal or elevated concentrations of growth hormone (GH). rhIGF-I is also approved for patients who have GH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01c886dcb65f19f417da04a44c3dfbdb
https://doi.org/10.1016/s1096-6374(10)70077-0