Zobrazeno 1 - 10
of 15
pro vyhledávání: '"John R. Zysk"'
Autor:
Donna L. Maier, Smita V. Ghanekar, Charles S. Elmore, Chi-Ming Lee, Min Ding, Jennifer L. Werkheiser, John R. Zysk, Vijay Chhajlani, Jianwei Liu
Publikováno v:
Synapse. 66:315-322
Neuronal nicotinic acetylcholine receptor (nAChR) agonists active at the alpha-7 (α-7) receptor subtype are potential therapeutics for cognitive deficits in schizophrenia, Alzheimer's disease, and other mental disorders. SSR180711, an α-7 selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ccedb9b957284923802ac9c174f5d27
https://doi.org/10.1002/syn.21513
https://doi.org/10.1002/syn.21513
Autor:
Donna L. Maier, Peter Ström, Jennifer L. Werkheiser, Teng Peng, David Tuke, Dan Widzowski, Peter N. Dorff, Charles S. Elmore, Ladislav Mrzljak, Jonas Malmquist, Min Ding, John R. Zysk
Publikováno v:
Synapse. 64:624-633
Positron emission tomography (PET) antagonist ligands such as [(11)C]-raclopride are commonly used to study dopamine D2 receptor (D2) binding of antipsychotics. It has been suggested that agonist radioligands bind preferentially to the high-affinity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33829240f6fb15ebbbbd2391ad4ca2b3
https://doi.org/10.1002/syn.20771
https://doi.org/10.1002/syn.20771
Autor:
Kari Ronningen, Yakov Pesah, Brooke W. Middlebrooks, John R. Zysk, Vijaya Tirunagaru, Graeme Mardon, Heather Burgess, Jude Prosser
Publikováno v:
genesis. 41:154-159
Previously published reports have suggested that misexpression of alpha-Synuclein in the Drosophila central nervous system causes neurodegeneration and progressive age-dependent locomotor dysfunction similar to pathologic and clinical manifestations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ca3bbea17b5ed147bdc2a93ed3a476e
https://doi.org/10.1002/gene.20106
https://doi.org/10.1002/gene.20106
Autor:
John R. Zysk, Yemisi Oluwatosin-Chigbu, Alan Robbins, John D. Reid, Jeffrey L. Arriza, Clay W Scott
Publikováno v:
Biochemical and Biophysical Research Communications. 309:679-684
Current hypotheses concerning the mechanism of neuronal cell death in Parkinson's disease (PD) and related synucleopathies propose a functional interaction between parkin and alpha-synuclein (alphaS). Recently parkin was shown to suppress mutant alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b70847f18f6016decca0ae0df4df531
https://doi.org/10.1016/j.bbrc.2003.08.059
https://doi.org/10.1016/j.bbrc.2003.08.059
Autor:
Rene Zeppetello, Michael Fedock, Scott Perschke, Adele Snowman, Evelyn Good, John R. Zysk, Sonia Chang, Rani Lopez, April Kinsler, Jason Lacombe
Publikováno v:
SLAS Discovery. 3:231-236
Cell lines provide a readily available source of target material for functional and molecular binding screens in drug discovery. The Cell PROFILE® program at NovaScreen® represents an effort to identify receptors and enzymes expressed in establishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b78469a029d1a659316df228f2041bd8
https://doi.org/10.1177/108705719800300310
https://doi.org/10.1177/108705719800300310
Autor:
John R. Zysk, William R. Baumbach
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 1:171-183
The development of high throughput, homogeneous pharmacologic and functional assays and their implementation in screening combinatorial libraries has increased the pace of stochastic. drug discovery in recent years. New, noninvasive approaches involv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feb23d5c4d1a1601cecc00e526e4d990
https://doi.org/10.2174/1386207301666220125212451
https://doi.org/10.2174/1386207301666220125212451
Autor:
William Edward Fieles, Mark Morris Stein, Reto Gadient, Becky Brockel, Donna L. Maier, Linda S. Sygowski, John R. Zysk, Peter Ström, Megan M. King, Richard C. Hastings, Nathan Spear, Vijay Chhajlani, Valerie Hoesch, Charles S. Elmore, Mylinh Do
Publikováno v:
Synapse (New York, N.Y.). 67(3)
The positive allosteric modulator (PAM) binding site for metabotropic glutamate receptor subtype 5 (mGlu5) lacks a readily available radio-labeled tracer fordetailed structure-activity studies. This communication describes a selective mGlu5 compound,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7419e2b23a629061bb13f2d3bbe8c003
https://pubmed.ncbi.nlm.nih.gov/23150216
https://pubmed.ncbi.nlm.nih.gov/23150216
Autor:
Min, Ding, Smita, Ghanekar, Charles S, Elmore, John R, Zysk, Jennifer L, Werkheiser, Chi-Ming, Lee, Jianwei, Liu, Vijay, Chhajlani, Donna L, Maier
Publikováno v:
Synapse (New York, N.Y.). 66(4)
Neuronal nicotinic acetylcholine receptor (nAChR) agonists active at the alpha-7 (α-7) receptor subtype are potential therapeutics for cognitive deficits in schizophrenia, Alzheimer's disease, and other mental disorders. SSR180711, an α-7 selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6ee9ccaac07baad89a2a35fae002d3c0
https://pubmed.ncbi.nlm.nih.gov/22108786
https://pubmed.ncbi.nlm.nih.gov/22108786
Autor:
Charles S. Elmore, James J. Doherty, Katharine S. Knappenberger, Vijay Chhajlani, Nathan Spear, Peter N. Dorff, Hongyan Liu, Dan Widzowski, Linda A. Sygowski, John R. Zysk
Publikováno v:
Synapse (New York, N.Y.). 65(1)
We previously reported the absence of high-affinity binding of the group II metabotropic glutamate receptor agonists LY 354,740 and LY 379,268 to the D2L dopamine receptor. A rebuttal to our findings has since been reported (see Introduction section)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a1224cd12ee9c453232b2593207ed9
https://pubmed.ncbi.nlm.nih.gov/20506301
https://pubmed.ncbi.nlm.nih.gov/20506301
Autor:
Phil Edwards, Cynthia Birr, Cynthia D. Sobotka-Briner, Gaochao Tian, Barry D. Greenberg, John R. Zysk, Clay W Scott, Mark Sylvester, Xiaodong Liu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52eddaf724c93ce04fad97b80304643e
https://europepmc.org/articles/PMC6741744/
https://europepmc.org/articles/PMC6741744/
