Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John R. Woolfrey"'
Autor:
Hua Yang, Bing-Yan Zhu, Ting Su, Deborah Volkots, Paul W. Wong, Robert M. Scarborough, John R. Woolfrey, Uma Sinha, Suiko Dam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:729-732
The structure-activity relationship of a novel series of substituted piperazinone-based factor Xa inhibitors is described. The most potent compound 34 displays IC(50) of 0.9 nM.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246edc7a1c0e4f7efe3d517bb30d61ef
https://doi.org/10.1016/s0960-894x(02)01038-7
https://doi.org/10.1016/s0960-894x(02)01038-7
Autor:
John R. Woolfrey, Mitchell A. Avery
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
We know today that structural changes in steroids can bring about potency alterations in animal pharmacology through a number of mechanisms. The processes that are affected include pharmacokinetic parameters such as drug absorption and drug distribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::824984cafc3d099638c8f761ab8bbb38
https://doi.org/10.1002/0471266949.bmc056
https://doi.org/10.1002/0471266949.bmc056
Autor:
Carlos R. Rodrigues, Fred E. Cohen, Maria Alvim-Gaston, Mitchell A. Avery, Eliezer J. Barreiro, Yogesh A. Sabnis, John R. Woolfrey
Publikováno v:
Journal of Medicinal Chemistry. 45:292-303
Artemisinin (1) is a unique sesquiterpene peroxide occurring as a constituent of Artemisia annua L. Because of the effectiveness of Artemisinin in the treatment of drug-resistant Plasmodium falciparum and its rapid clearance of cerebral malaria, deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5434643d3205321974a20d0bb1b86d7
https://doi.org/10.1021/jm0100234
https://doi.org/10.1021/jm0100234
Publikováno v:
Journal of Computer-Aided Molecular Design. 12:165-181
Two three-dimensional quantitative structure-activity relationship (3D-QSAR) methods, comparative molecular field analysis (CoMFA) and hypothetical active site lattice (HASL), were compared with respect to the analysis of a training set of 154 artemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3beaa8bb8aeb84b5bb26412ebd5f49e2
https://doi.org/10.1023/a:1007967517859
https://doi.org/10.1023/a:1007967517859
Publikováno v:
ChemInform. 30
Publisher Summary This chapter discusses the synthesis and structure-activity relationships of peroxidic antimalarials based on artemisinin. Synthetic methodology has been developed for introducing substituents at C-9, O- 11 (as N-R), and C-3 via a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f484b1024c201b49dc1f4d269a131c7b
https://doi.org/10.1002/chin.199941309
https://doi.org/10.1002/chin.199941309
Publikováno v:
ChemInform. 32
The rare series of doubly-linked proteracacinidin-type oligoflavanoids is extended by identification of four new analogues, oritin-(4α→7, 5→6)-epioritin-4α-ol 3, oritin-(4β→7, 5→6)-epioritin-4α-ol 5, epioritin-(4β→7, 5→6)-epioritin-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db4cfbc35dd7901bbe451b1733f12d61
https://doi.org/10.1002/chin.200120213
https://doi.org/10.1002/chin.200120213
Autor:
Mitchell A. Avery, John R. Woolfrey
Publikováno v:
Kirk-Othmer Encyclopedia of Chemical Technology
Adrenal-cortical hormones, following the introduction of cortisone and hydrocortisone nearly a half-century ago, have continued to be the drug of choice in treatment of afflictions ranging from skin rash to severe acute inflammatory disorders and are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::07cd25b709519b817c9904102279087f
https://doi.org/10.1002/0471238961.0815181301220518.a01
https://doi.org/10.1002/0471238961.0815181301220518.a01
Publisher Summary This chapter discusses the synthesis and structure-activity relationships of peroxidic antimalarials based on artemisinin. Synthetic methodology has been developed for introducing substituents at C-9, O- 11 (as N-R), and C-3 via a t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87204034dd5331f966957bb3059d1fa5
https://doi.org/10.1016/s1067-5698(99)80005-4
https://doi.org/10.1016/s1067-5698(99)80005-4