Zobrazeno 1 - 10 of 47 pro vyhledávání: '"John R. Wetterau"'
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Akademický článek
Effects of pharmacological inhibition of the sodium‐dependent phosphate cotransporter 2b (NPT2b) on intestinal phosphate absorption in mouse and rat models
Autor: Xiaojun Wang, Yanping Xu, Xiaohong Yu, Asim Dey, Hong Y. Zhang, Charity M. Zink, Derek Wodka, Gina Porter, William F. Matter, Leah Porras, Charles A. Reidy, Jeffrey A. Peterson, Brian E. Mattioni, Joseph V. Haas, Mark C. Kowala, John R. Wetterau
Publikováno v: Pharmacology Research & Perspectives, Vol 10, Iss 2, Pp n/a-n/a (2022)
Abstract An excess phosphate burden in renal disease has pathological consequences for bone, kidney, and heart. Therapies to decrease intestinal phosphate absorption have been used to address the problem, but with limited success. Here, we describe t
Externí odkaz: https://doaj.org/article/b759409794b4455683e748deb0fd6706
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3
Akademický článek
Evidence that microsomal triglyceride transfer protein is limiting in the production of apolipoprotein B-containing lipoproteins in hepatic cells
Autor: Haris Jamil, Ching-Hsuen Chu, John K. Dickson, Jr., Ying Chen, Mujing Yan, Scott A. Biller, Richard E. Gregg, John R. Wetterau, David A. Gordon
Publikováno v: Journal of Lipid Research, Vol 39, Iss 7, Pp 1448-1454 (1998)
The microsomal triglyceride transfer protein (MTP) is a heterodimeric lipid transfer protein that is required for the assembly and secretion of apolipoprotein B (apoB)-containing lipoproteins. A key unresolved question is whether the MTP-mediated ste
Externí odkaz: https://doaj.org/article/16c45b43aabf402ba2850fe8686267a1
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4
Akademický článek
Estimating the distribution of a novel clinical biomarker (FGF-23) in the US population using findings from a regional research registry.
Autor: Joseph A Johnston, David R Nelson, Limin Zhang, Sarah E Curtis, James R Voelker, John R Wetterau
Publikováno v: PLoS ONE, Vol 14, Iss 6, p e0218435 (2019)
Evidence of involvement of novel biomarkers in disease pathogenesis from research cohorts often precedes an understanding of their distributions in broader populations. This study aimed to estimate the distribution of fibroblast growth factor 23 (FGF
Externí odkaz: https://doaj.org/article/fb0a3e26587641c9a9d38b7698912d81
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5
Estimating the distribution of a novel clinical biomarker (FGF-23) in the US population using findings from a regional research registry
Autor: James Voelker, Limin Zhang, Sarah E Curtis, David R. Nelson, John R. Wetterau, Joseph A. Johnston
Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 6, p e0218435 (2019)
Evidence of involvement of novel biomarkers in disease pathogenesis from research cohorts often precedes an understanding of their distributions in broader populations. This study aimed to estimate the distribution of fibroblast growth factor 23 (FGF
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c86e0113b0490b7ca24793096f40e2f
https://doi.org/10.1371/journal.pone.0218435
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6
Dapagliflozin, a Selective SGLT2 Inhibitor, Improves Glucose Homeostasis in Normal and Diabetic Rats
Autor: John R. Wetterau, Deborah Hagan, William N. Washburn, Wei Meng, Joseph R. Taylor, Songping Han, Scott A. Biller, Jean M. Whaley, Li Xin
Publikováno v: Diabetes. 57:1723-1729
OBJECTIVE—The inhibition of gut and renal sodium-glucose cotransporters (SGLTs) has been proposed as a novel therapeutic approach to the treatment of diabetes. We have identified dapagliflozin as a potent and selective inhibitor of the renal sodium
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5864104a49101cfc9c6b52636c8afe
https://doi.org/10.2337/db07-1472
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8
5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP
Autor: John R. Wetterau, Thomas Harrity, Richard B. Sulsky, Jeffrey A. Robl, Kern G. Jolibois, Fergal Connolly, Scott A. Biller, Lori Kunselman
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 14:5067-5070
5-Carboxamido-1,3,2-dioxaphosphorinanes have been identified as potent inhibitors of microsomal triglyceride-transfer protein. The 1,3,2-dioxaphosphorine functionality acted as a neutral and stable replacement for piperidine and piperidine N-oxide.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b1bcb5468af7eea694a534e738ef69
https://doi.org/10.1016/j.bmcl.2004.07.069
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9
A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors
Autor: David A. Gordon, Ligaya M. Simpkins, William A. Slusarchyk, David R. Magnin, Chongqing Sun, Prakash Taunk, Jamil Haris, Lori Kunselman, Ying Chen, Scott A. Biller, John R. Wetterau, Fergal Connolly, Jeffrey A. Robl, John K. Dickson, Talal Sabrah, Thomas Harrity, Shih-Jung Lan, Richard B. Sulsky, Tammy C. Wang
Publikováno v: Journal of Medicinal Chemistry. 44:851-856
A series of benzimidazole-based analogues of the potent MTP inhibitor BMS-201038 were discovered. Incorporation of an unsubstituted benzimidazole moiety in place of a piperidine group afforded potent inhibitors of MTP in vitro which were weakly activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be68a36dea52f3ff5c3ddb2e2c700e83
https://doi.org/10.1021/jm000494a
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