Zobrazeno 1 - 10
of 496
pro vyhledávání: '"John R. Walker"'
Autor:
Stephen J. P. Pratt, Christopher M. Plunkett, Guray Kuzu, Ton Trinh, Joshua Barbara, Paula Choconta, Doug Quackenbush, Truc Huynh, Anders Smith, S. Whitney Barnes, Joel New, James Pierce, John R. Walker, James Mainquist, Frederick J. King, Jimmy Elliott, Scott Hammack, Rebekah S. Decker
Publikováno v:
APL Bioengineering, Vol 8, Iss 2, Pp 026129-026129-13 (2024)
Mechanobiology is a rapidly advancing field, with growing evidence that mechanical signaling plays key roles in health and disease. To accelerate mechanobiology-based drug discovery, novel in vitro systems are needed that enable mechanical perturbati
Externí odkaz:
https://doaj.org/article/aabc65c393f942c5934f91911c5a8d09
Autor:
Jerlin Joyees, Ruth Ann Marrie, Charles N. Bernstein, James M. Bolton, John D. Fisk, Lesley A. Graff, Carol Hitchon, Scott B. Patten, Kaarina Kowalec, for the CIHR team in defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease, Lesley Graff, John R. Walker, Carol A. Hitchon, Lisa M. Lix, James Bolton, Jitender Sareen, Alan Katz, James J. Marriott, Alexander Singer, Renée El-Gabalawy, Christine A. Peschken, Ryan Zarychanski, Lindsay I. Berrigan
Publikováno v:
Frontiers in Psychiatry, Vol 14 (2023)
IntroductionImmune-mediated inflammatory diseases (IMID), such as multiple sclerosis (MS), inflammatory bowel disease (IBD) or rheumatoid arthritis (RA) have high rates of elevated anxiety symptoms. This can may worsen functioning and increase IMID d
Externí odkaz:
https://doaj.org/article/5d7f536b74724762b181c211f757311b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12419 (2023)
Topoisomerase inhibitor camptothecin (CPT) induces fork stalling and is highly toxic to proliferating cells. However, how cells respond to CPT-induced fork stalling has not been fully characterized. Here, we report that Cockayne syndrome group B (CSB
Externí odkaz:
https://doaj.org/article/20ec849e6b14483ebfba3781dd76d1da
Autor:
John R. Walker, Xu-Dong Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10212 (2022)
A variety of endogenous and exogenous insults are capable of impeding replication fork progression, leading to replication stress. Several SNF2 fork remodelers have been shown to play critical roles in resolving this replication stress, utilizing dif
Externí odkaz:
https://doaj.org/article/6fbf6709185043a387c5e15ad1d693fd
Autor:
Hank Cheng, Lisa M. Deaton, Minhua Qiu, Sukwon Ha, Reynand Pacoma, Jianmin Lao, Valerie Tolley, Rita Moran, Amber Keeton, John R. Lamb, John Fathman, John R. Walker, Andrew M. Schumacher
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Repeated mild traumatic brain injury (rmTBI) can lead to development of chronic traumatic encephalopathy (CTE), which is characterized by progressive neurodegeneration with presence of white matter damage, gliosis and hyper-phosphorylated tau. While
Externí odkaz:
https://doaj.org/article/277b405ca92b44e9acbaa740b085ee82
Autor:
Nicole L. Batenburg, John R. Walker, Sylvie M. Noordermeer, Nathalie Moatti, Daniel Durocher, Xu-Dong Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Cockayne syndrome group B protein (CSB) is a multifunctional chromatin remodeler involved in double-strand break repair. Here the authors investigate the molecular post-translational signals regulating CSB activity.
Externí odkaz:
https://doaj.org/article/e4816a9ac34e4a8cb9e3e31109884db4
Autor:
Ruth Ann Marrie, Randy Walld, James M. Bolton, Jitender Sareen, John R. Walker, Scott B. Patten, Alexander Singer, Lisa M. Lix, Carol A. Hitchon, Renée El-Gabalawy, Alan Katz, John D. Fisk, Charles N. Bernstein, For the CIHR Team in Defining the Burden and Managing the Effects of Psychiatric Comorbidity in Chronic Immunoinflammatory Disease
Publikováno v:
BMC Research Notes, Vol 10, Iss 1, Pp 1-6 (2017)
Abstract Objective Researchers have developed case definitions to estimate incidence and lifetime prevalence of depression and anxiety disorders in multiple sclerosis (MS) using administrative data. For policymakers however, the prevalence of a disea
Externí odkaz:
https://doaj.org/article/de6bed3888ee4926b11571b4dad954fe
Autor:
John R. Walker, Megan Ryan Detloff
Publikováno v:
Biology, Vol 10, Iss 10, p 976 (2021)
Neuroplasticity is a robust mechanism by which the central nervous system attempts to adapt to a structural or chemical disruption of functional connections between neurons. Mechanical damage from spinal cord injury potentiates via neuroinflammation
Externí odkaz:
https://doaj.org/article/68fc34e24e054d038de01af6cd1e08be
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 7, p 3379 (2021)
Cockayne syndrome group B protein (CSB), a member of the SWI/SNF superfamily, resides in an elongating RNA polymerase II (RNAPII) complex and regulates transcription elongation. CSB contains a C-terminal winged helix domain (WHD) that binds to ubiqui
Externí odkaz:
https://doaj.org/article/1fc6f007c2f44be5b2aaa3319523b6b5
Autor:
Marian L. Logrip, John R. Walker, Lydia O. Ayanwuyi, Valentina Sabino, Roberto Ciccocioppo, George F. Koob, Eric P. Zorrilla
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Alcoholism is a pervasive societal problem, yet available pharmacotherapies fail to treat most sufferers. The type 1 corticotropin-releasing factor (CRF1) receptor has received much attention for its putative role in the progression to alcohol depend
Externí odkaz:
https://doaj.org/article/ad3a8a96b995451ba549aef20c322d04