Zobrazeno 1 - 10
of 128
pro vyhledávání: '"John R. Turtle"'
Publikováno v:
Andrologia. 17:488-496
We have investigated testicular function in 28 insulin-dependent diabetic men under the age of 50 years and 119 age-matched controls. Diabetics had reduced testicular volume, semen volume, total and total motile sperm output while plasma LH and FSH l
Autor:
Kim T. Tran, Christopher J. O'Brien, Dominique Dubourdieu, Stanley W. McCarthy, Qihan Dong, John R. Turtle, Nicholas A. Packham, Christopher S. Lauer, Elizabeth L. Chua, Wan Man Wu
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 85:2733-2739
The world’s highest incidence of thyroid cancer has been reported among females in New Caledonia, a French overseas territory in the Pacific located between Australia and Fiji. To date, no molecular genetic studies in this population are available.
Publikováno v:
BioTechniques. 27:512-520
Competitive reverse transcription (RT)-PCR is now considered a reliable technique for determining the relative or absolute copy number of target mRNAs in tissue or cells. The method relies on a synthetic RNA competitor molecule with identical sequenc
Publikováno v:
Diabetes Research and Clinical Practice. 37:101-108
Expansion of the glomerular mesangium is a consistent finding of diabetic nephropathy. Negatively charged proteoglycans are an integral part of the mesangium and their synthesis and degradation is disturbed in many forms of glomerulosclerosis. The me
Publikováno v:
Microvascular Research. 53:173-178
Mesangium enlargement is a central feature of diabetic nephropathy and almost certainly plays a pathogenic role in this condition. Previous studies have shown that mesangium degradation is reduced in a high glucose mileau. Plasmin has been shown to p
Publikováno v:
Diabetic Medicine. 13:758-763
Nephropathy is a serious microvascular complication of diabetes mellitus which is preceded by a period of microalbuminura. Increased loss of proteoglycan (PG) from glomerular basement (GBM) has been postulated to alter glomerular charge selectivity w
Autor:
Lynda Molyneaux, John R. Turtle, Glynis P. Ross, Maria I. Constantino, Dennis K. Yue, A G Child
Publikováno v:
Diabetic Medicine. 13:748-752
To study why gestational diabetes (GDM) is more common in some ethnic groups than others, we tested the hypothesis that GDM is more common in people who are temporally closer to developing non-insulin-dependent (Type 2) diabetes mellitus (NIDDM). The
Publikováno v:
Diabetic Medicine. 13:145-149
Mesangium enlargement and glomerular basement membrane thickening are cardinal features of diabetic nephropathy. The reasons for these changes are uncertain but decreased degradation of extracellular matrix may play a role. Mesangium degradation can
Autor:
Adrian Gillin, A. F. Phippard, Annemarie Hennessy, Alan Sinclair, Dennis K. Yue, Scott Heffernan, John R. Turtle, David J. Tiller, Susan V. McLennan, John S. Horvath
Publikováno v:
Journal of Medical Primatology. 24:29-34
Over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. We describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. S
Publikováno v:
Microvascular Research. 48:179-189
Abnormalities of retinal pericytes and endothelial cells are prominent features of diabetic retinopathy. In this study, we used cultures of bovine retinal cells to examine the regulation of cell-associated proteoglycans, a class of highly sulfated ma