Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John R. Torrente"'
Autor:
Daniel R. Schroeder, Vivekananda M. Vrudhula, Charlie M. Conway, Cen Xu, Gene M. Dubowchik, Bireshwar Dasgupta, John E. Macor, Sokhom S. Pin, Edward S. Kozlowski, John R. Torrente
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2744-2748
An oxidation product (5) formed during the synthesis of BIBN-4096BS (1) was found to be a potent CGRP antagonist (IC50 = 0.11 nM). While 5 was found to be ten-fold less potent than 1, another analog 8 with lower molecular weight containing the oxidiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf87bcc15dea26e802cf64a9a0d9223
https://doi.org/10.1016/j.bmcl.2014.04.033
https://doi.org/10.1016/j.bmcl.2014.04.033
Autor:
Houston H. Davis, Marie A. Geissler, Arlene S. Eison, Lawrence G. Iben, Robert N. Wright, Jonas A. Gylys, Frank D. Yocca, John R. Torrente
Publikováno v:
Drug Development Research. 29:18-24
The compound BMY 33462 (4-amino-N-(1-azabicyclo-[2,2,2]oct-3-yl)-2-(butan-2-one-3-yl)oxy-5-chlorobenzamine 1.25 fumerate hydrate) has been shown to be a selective and potent serotonin type-3 (5-HT3) receptor antagonist. Its receptor binding profile i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8184a7eecc7f7ab2ae35806372d870f9
https://doi.org/10.1002/ddr.430290103
https://doi.org/10.1002/ddr.430290103
Autor:
Lawrence G. Iben, Joseph P Yevich, Qi Gao, Michael F. Dee, Arlene Stark, Ronald J. Mattson, John R. Torrente, Kenneth M. Boy
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(17)
Conformationally constrained aryl cyclohexanes and cyclohexenes based on aryl cyclohexanols 1 were prepared. Locking the aryl ring in plane with the cyclohexane moiety provided potent SSRIs 3. Conversely, fixing the aryl ring perpendicular to the cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e7d615be4af78eb7acc7003345aec80
https://pubmed.ncbi.nlm.nih.gov/15357973
https://pubmed.ncbi.nlm.nih.gov/15357973
Autor:
Suresh Yeola, Yufen Zhao, Aiming Gao, Ronald J. Mattson, Michael A. Poss, Jane Palmer, Jeffrey A. Deskus, John D. Catt, Ashok V. Purandare, Dalton King, Arlene Stark, John R. Torrente, Graham Johnson, Michael F. Dee, David R. Tortolani, Jonathan L. Ditta, Derek J. Denhart, Hua Yang, James R. Epperson
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(16)
The present studies have identified a series of aminotriazines as novel 5-HT(7) receptor antagonists. Compounds 10 and 17 have high affinity for the 5-HT(7) receptor and do not bind to either the 5-HT(2C) or 5-HT(6) receptors. These compounds produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea63093d8cad6c62016c160f857f8fc7
https://pubmed.ncbi.nlm.nih.gov/15261279
https://pubmed.ncbi.nlm.nih.gov/15261279