Zobrazeno 1 - 10
of 92
pro vyhledávání: '"John R. Spurzem"'
Publikováno v:
Alcohol. 36:31-40
Most people who abuse alcohol are cigarette smokers. Previously, we have shown that malondialdehyde, an inflammation product of lipid peroxidation, and acetaldehyde, a component of both ethanol metabolism and cigarette smoke, form protein adducts tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b87f6c01a452cd0dde5500f0fb12334
https://doi.org/10.1016/j.alcohol.2005.06.002
https://doi.org/10.1016/j.alcohol.2005.06.002
Autor:
Todd A. Wyatt, Debra J. Romberger, Julie A. Stoner, Joseph H. Sisson, Joseph Owens-Ream, John R. Spurzem, David M. Mannino
Publikováno v:
Alcohol. 36:19-30
Little is known about the effect of moderate alcohol intake on lung function in the general population. Because moderate alcohol intake appears to reduce cardiovascular disease risk, we hypothesized that moderate alcohol intake is associated with bet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3034f4cee05fe04f3fdee443c050bc73
https://doi.org/10.1016/j.alcohol.2005.05.002
https://doi.org/10.1016/j.alcohol.2005.05.002
Autor:
M. Illig, Yuichi Adachi, Ilja Striz, D. J. Romberger, S Carnevali, S. I. Rennard, John R. Spurzem, Tadashi Mio
Publikováno v:
Tissue and Cell. 35:459-469
Radiation exposure is known to impair healing in irradiated areas. Fibroblasts play a major role in the production and modification of extracellular matrix in wound repair. Since one important aspect of wound repair is the contraction of the wound, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1415072bc26b8dc66779b597d47f88
https://doi.org/10.1016/s0040-8166(03)00072-7
https://doi.org/10.1016/s0040-8166(03)00072-7
Publikováno v:
Alcohol. 31:31-38
Ethanol exposure in airway epithelium increases cyclic AMP (cAMP)-dependent protein kinase (PKA) activity. Activation of PKA and cyclic guanosine monophosphate (cGMP)-dependent protein kinase (PKG) has been shown to increase ciliary beat frequency (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5461f708c3cfcb534f82947054bf64
https://doi.org/10.1016/j.alcohol.2003.06.005
https://doi.org/10.1016/j.alcohol.2003.06.005
Publikováno v:
Clinics in Chest Medicine. 23:795-810
Agricultural work is associated with high rates of injury, disability, and illness. Agricultural workers are at increased risk for a variety of illnesses including respiratory disorders, dermatologic conditions, and cancer. The recognition of organic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5511563ecedf7bc9d8920b7b9ef99451
https://doi.org/10.1016/s0272-5231(02)00024-2
https://doi.org/10.1016/s0272-5231(02)00024-2
Publikováno v:
Experimental Biology and Medicine. 227:1047-1053
Relaxin is an insulin-like serum protein secreted during pregnancy and found in many tissues, including the lung. Relaxin is reported to stimulate epithelial cell proliferation, but the effects of relaxin on airway epithelium are unknown. We tested t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b654fd1208175281384a18e8240e722f
https://doi.org/10.1177/153537020222701114
https://doi.org/10.1177/153537020222701114
Autor:
Masashi Kawamoto, Stephen I. Rennard, John R. Spurzem, Yoichi Nakamura, Debra J. Romberger, Luigi Allegra, Tadashi Kohyama, Tom Veys, Ronald F. Ertl, Vincenzo Valenti
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L1257-L1263
Fibroblasts are the major source of extracellular connective tissue matrix, and the recruitment, accumulation, and stimulation of these cells are thought to play important roles in both normal healing and the development of fibrosis. Prostaglandin E2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a7b3889c34de3d4d982d550b6001e81
https://doi.org/10.1152/ajplung.2001.281.5.l1257
https://doi.org/10.1152/ajplung.2001.281.5.l1257
Autor:
John R. Spurzem, Debra J. Romberger, Fu Qiang Wen, Yun Kui Zhu, Ronald F. Ertl, Stephen I. Rennard, Xiangde Liu, Hangjun Wang, Tadashi Kohyama
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 25:620-627
Proteolytic degradation of extracellular matrix is thought to play an important role both in emphysema and in tissue development and repair. Retinoic acid has been suggested to modify tissue injury, and in an animal model of emphysema may induce alve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d11e7b03c859cdd6926b7e481c50fac7
https://doi.org/10.1165/ajrcmb.25.5.4495
https://doi.org/10.1165/ajrcmb.25.5.4495
Autor:
Myron L. Toews, Stephen I. Rennard, Xiangde Liu, Tadashi Mio, John R. Spurzem, Debra J. Romberger, Yuichi Adachi
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 281:L164-L171
Bradykinin is a multifunctional mediator of inflammation believed to have a role in asthma, a disorder associated with remodeling of extracellular connective tissue. Using contraction of collagen gels as an in vitro model of wound contraction, we ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8895ed111efaf2b9013febc77c968cb8
https://doi.org/10.1152/ajplung.2001.281.1.l164
https://doi.org/10.1152/ajplung.2001.281.1.l164
Autor:
Takeshi Umino, John R. Spurzem, Xiangde Liu, Stephen I. Rennard, M. Patricia Leuschen, Lidia S. Manouilova, Hangjun Wang, Yunkui Zhu
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 22:702-707
Contraction of type I collagen gels is an in vitro model of tissue remodeling. In addition to fibroblasts, some epithelial cells can mediate this process. We therefore hypothesized that alveolar epithelial cells might contract extracellular matrices
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20e4291d7f8c6c26c919286c74b7367
https://doi.org/10.1165/ajrcmb.22.6.3806
https://doi.org/10.1165/ajrcmb.22.6.3806