Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John R. Sedy"'
Publikováno v:
The Journal of Immunology. 202:2057-2068
CD160 is highly expressed by NK cells and is associated with cytolytic effector activity. Herpes virus entry mediator (HVEM) activates NK cells for cytokine production and cytolytic function via CD160. Fc-fusions are a well-established class of thera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b270c09d1afefa3c3c343cae5426d313
https://doi.org/10.4049/jimmunol.1801449
https://doi.org/10.4049/jimmunol.1801449
Autor:
Marisol Veny, Richard Virgen-Slane, Lisa Elmén, Mary Olivia Balmert, John R. Sedy, Michelle A. Hurchla, Jennifer Nguyen, Scott N. Peterson, Jr-Wen Shui, Sarah Huang, Mitchell Kronenberg, Caroline Stienne, Elizabeth Chappell, Kenneth M. Murphy, Carl F. Ware
Publikováno v:
Cell reports. 38(12)
The Btla inhibitory receptor limits innate and adaptive immune responses, both preventing the development of autoimmune disease and restraining anti-viral and anti-tumor responses. It remains unclear how the functions of Btla in diverse lymphocytes c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c212f0cabfd349d1886c0d797c5013ea
https://pubmed.ncbi.nlm.nih.gov/35320716
https://pubmed.ncbi.nlm.nih.gov/35320716
Autor:
Robert Lemos, Garth Powis, Lewis R. Roberts, Carl F. Ware, Xiuping Liu, John R. Sedy, Vasileos Bekiaris, Timothy Sargis, Adriana Charbono, Mei Yee Koh, Geoffrey Grandjean, Mihai Gagea, Galina Kiriakova
Publikováno v:
Hepatology. 63:1576-1591
The hypoxia-inducible factor (HIF), HIF-1, is a central regulator of the response to low oxygen or inflammatory stress and plays an essential role in survival and function of immune cells. However, the mechanisms regulating nonhypoxic induction of HI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfe3fa4c2709cc01ee963f5eef6033a4
https://doi.org/10.1002/hep.28468
https://doi.org/10.1002/hep.28468
Autor:
Aaron J. Tyznik, Chip Lomas, Wai Lin, Gisele V. Baracho, Stephanie Widmann, John R. Sedy, Xhiaoshan Shi
Publikováno v:
Cancer Research. 80:4967-4967
As for most neoplasms, the pathogenesis and progression of B-cell malignancies is a dynamic process involving reciprocal interactions between malignant cells and surrounding components in the tumor microenvironment. In the case of certain B-cell lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fb38d6a5ebe6d12b21506e582b8baa0
https://doi.org/10.1158/1538-7445.am2020-4967
https://doi.org/10.1158/1538-7445.am2020-4967
Autor:
John R Sedy, Wai Lin, Sarah Huang, M. Olivia Balmert, Jennifer Nguyen, Aref Moshayedi, Carl Ware
Publikováno v:
The Journal of Immunology. 204:165.19-165.19
Herpesvirus entry mediator (HVEM; TNFRSF14) is frequently mutated in human cancer with a high degree of mutations in follicular and diffuse large B cell lymphoma. In lymphocytes, HVEM receptors are activated by its ligands LIGHT (TNFSF14) and Lymphot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86730d34fc4dfa7c30d6a350e3fdfec5
https://doi.org/10.4049/jimmunol.204.supp.165.19
https://doi.org/10.4049/jimmunol.204.supp.165.19
Autor:
Mary Olivia Balmert, Audrey Re, Carl F. Ware, Dikran Aivazian, Brian C. Ware, Brian Robert Miller, Paula S. Norris, Ivana Nemčovičová, John R. Sedy, Aref Moshayedi, Wendell Smith
Publikováno v:
The FASEB Journal. 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5689a2a5b00505255e0ca0cd276cd7ca
https://doi.org/10.1096/fasebj.2018.32.1_supplement.792.5
https://doi.org/10.1096/fasebj.2018.32.1_supplement.792.5
Publikováno v:
The Journal of Immunology. 202:129.13-129.13
Mucosal immunity in the gut is achieved in part through cellular connections between lymphoid cells such as regulatory-T cells (Treg), T follicular helper cells (Tfh), T follicular regulatory cells (Tfr) and Germinal Center B cells (GC B). Btla (B an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e0129eb88e8faae50dc543e8beb603c0
https://doi.org/10.4049/jimmunol.202.supp.129.13
https://doi.org/10.4049/jimmunol.202.supp.129.13
Autor:
John R. Sedy, Shilpi Sharma, Matthew G. Macauley, Salvatore Albani, Paula S. Norris, Roberto Spreafico, Brian C. Ware, Antje Rhode-Kurnow, Vasileios Bekiaris, Nini Huang, Carl F. Ware, Maura Rossetti
Publikováno v:
The Journal of Immunology. 191:4611-4618
Innate lymphoid cells encompass a diverse array of lymphocyte subsets with unique phenotype that initiate inflammation and provide host defenses in specific microenvironments. In this study, we identify a rare human CD4+CD3− innate-like lymphoid po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1de1471d3536b0967db7ff558b735c6
https://doi.org/10.4049/jimmunol.1301672
https://doi.org/10.4049/jimmunol.1301672
Autor:
John R. Sedy, Paula S. Norris, Marcel D. Fremont, Daved H. Fremont, Carl F. Ware, Kenneth M. Murphy, Christopher A. Nelson
Publikováno v:
The Journal of Immunology. 180:940-947
The B and T lymphocyte attenuator (BTLA) appears to act as a negative regulator of T cell activation and growth. BTLA specifically interacts with herpesvirus entry mediator (HVEM), a member of the TNFR family. Herein, we have undertaken surface plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8400929b4794306f2318b5bb54e3ab0
https://doi.org/10.4049/jimmunol.180.2.940
https://doi.org/10.4049/jimmunol.180.2.940
Publikováno v:
The Journal of Immunology. 178:6073-6082
B and T lymphocyte attenuator (BTLA; CD272) can deliver inhibitory signals to B and T cells upon binding its ligand herpesvirus entry mediator. Because CD28, CTLA-4, programmed death-1, and ICOS regulate the development of acute graft-vs-host disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dadd4c3becd215f2dbbd34a261446b2
https://doi.org/10.4049/jimmunol.178.10.6073
https://doi.org/10.4049/jimmunol.178.10.6073