Zobrazeno 1 - 10
of 38
pro vyhledávání: '"John R. Rizzo"'
Autor:
John R. Rizzo, Tony Y. Zhang
Publikováno v:
CHIMIA, Vol 60, Iss 9 (2006)
An asymmetric synthesis of navaglitazar, a peroxisome proliferator activated receptor (PPAR) ? agonist, from commercially available (+)-methyl (2S,3R)-3-(4-methoxyphenyl)glycidate, is described. The new synthesis features high overall yield, low solv
Externí odkaz:
https://doaj.org/article/fdc5ad7f1f7f4905b6eba137c2761b4c
Publikováno v:
Experimental Brain Research
Experimental Brain Research, 2023, Experimental Brain Research, ⟨10.1007/s00221-023-06550-8⟩
Experimental Brain Research, 2023, Experimental Brain Research, ⟨10.1007/s00221-023-06550-8⟩
In complex visuomotor tasks, such as cooking, people make many saccades to continuously search for items before and during reaching movements. These tasks require use of short-term memory and task-switching (e.g., switching search between vegetables
Autor:
Chuanren Liu, Jing Chen, Ping Huang, John Burnett, Peter J. Lindsay-Scott, Xin Zhang, Jianping Chen, Craig White, John R. Rizzo, Mai Khanh Hawk, Sarah J. Ryan, Yu Lu
Publikováno v:
Organic Process Research & Development. 25:1167-1175
This article describes the use of tetramethylammonium fluoride tetrahydrate (TMAF·4H2O) for the large-scale preparation of a challenging 4-fluorothiazole. Commercially available TMAF·4H2O was procu...
Autor:
Katarina Kadlecikova, John R. Rizzo, Mo Jia, Peter G. Houghton, Conchita Fernandez Garcia, Kevin P. Cole, Jeffery Richardson, Jared L. Piper, Junliang Hao, Amy C. DeBaillie, Peng Liu, Daniel S. Richards, Ping Huang
Publikováno v:
Organic Process Research & Development. 24:2549-2564
The evolution from early medicinal chemistry to large-scale production of the chemical synthesis of Lilly D1 positive allosteric modulator mevidalen (LY3154207) and its hydroxybenzoate cocrystal is...
Publikováno v:
ChemistrySelect. 4:4258-4261
Publikováno v:
Organic & Biomolecular Chemistry. 17:3056-3065
Our annulation strategy utilized for the synthesis of 2-azaspiro[3.4]octane is explained. Three successful routes for the synthesis were developed. One of the approaches involved annulation of the cyclopentane ring and the remaining two approaches in
Autor:
Tony Y. Zhang, Hannah Yu, John R. Rizzo, Jeffrey A. Ward, Thomas M. Koenig, Rachel N. Richey, David Mitchell, Marvin M. Hansen, Neil J. Kallman, Ryan J. Linder
Publikováno v:
Organic Process Research & Development. 21:208-217
A practical pilot plant convergent synthesis of MR antagonist LY2623091 was established. For synthesis convergence, a vinyl bromide geometric isomer and chiral alaninol derivative were required building blocks. Key to the synthesis route development
Autor:
Srinivasan Chandrasekhar, Bradley Condon, Matthew Allen Schiffler, Kuklish Steven Lee, Kim Euibong Jemes, Bryan H. Norman, John R. Rizzo, Jeremy Schulenburg York, Kristina M. Campanale, Stefan Jon Thibodeaux, Richard E. Rathmell, Michael J. Hickey, Christopher Groshong, Shobha N. Bhattachar, Norman Earle Hughes, Anita K. Harvey, John G. Luz, Stephen Antonysamy, Scott Alan Jones, Timothy Andrew Woods, Prashant V. Desai, Matthew J. Fisher, Xiao-Peng Yu, Thomas W. Seng
Publikováno v:
Journal of Medicinal Chemistry. 59:194-205
As part of a program aimed at the discovery of antinociceptive therapy for inflammatory conditions, a screening hit was found to inhibit microsomal prostaglandin E synthase-1 (mPGES-1) with an IC50 of 17.4 μM. Structural information was used to impr
Autor:
Jian Wang, Javier Magano, Mark John Pozzo, Michael Lovdahl, John R. Rizzo, John J. Teixeira, David Tumelty, John Brennan, Brandon Bock, Durgesh V. Nadkarni, Mark T. Maloney, Douglas Farrand, Wendy K. Oliver
Publikováno v:
Organic Process Research & Development. 18:142-151
An optimized and scalable process to manufacture peptide–linker conjugate 1 is reported that avoids the chromatographic purification and lyophilization that are typically required for the isolation of this type of compound. An operationally simple
Autor:
Gregory A. Stephenson, Bret A. Astleford, Dana L. T. Laird, John R. Rizzo, Adam D. McFarland, Todd D. Maloney, Nicholas A. Magnus, J. Craig Ruble, James P. Wepsiec
Publikováno v:
The Journal of Organic Chemistry. 78:5768-5774
Serotonin norepinephrine reuptake inhibitor (SNRI) pyrrolidinyl ether 2 was synthesized by employing a dynamic kinetic resolution (DKR) with enantio- and diastereoselective hydogenation on β-keto-γ-lactam 8 to afford β-hydroxy-γ-lactam 9 with 96%