Zobrazeno 1 - 10
of 70
pro vyhledávání: '"John R. Proudfoot"'
Autor:
Steven J. Taylor, Asitha Abeywardane, Shuang Liang, Zhaoming Xiong, John R. Proudfoot, Bennett Sandy Farmer, Donghong A. Gao, Alexander Heim-Riether, Lana Louise Smith-Keenan, Ingo Muegge, Yang Yu, Qiang Zhang, Donald Souza, Mark Panzenbeck, Daniel Goldberg, Melissa Hill-Drzewi, Mariana Margarit, Brandon Collins, John Xiang Li, Ljiljana Zuvela-Jelaska, Jun Li, Neil A. Farrow
Publikováno v:
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
Externí odkaz:
https://doaj.org/article/28925716e0524cb7af79c7a4126b692b
Autor:
Huaping Zhang, Marta K. Dudek, John R. Proudfoot, Michał Gleńsk, Victor W. Day, Jan A. Gliński, Izabela D. Madura
Publikováno v:
Journal of Natural Products. 82:3477-3481
Prolonged storage of technical abamectin as well as avermectin B1a samples yielded a previously unknown derivative, designated here as compound 1. Detailed NMR analysis and X-ray crystallography allowed us to determine the structure of this compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::184ffc579359697055e42e3f805f207c
https://doi.org/10.1021/acs.jnatprod.9b00524
https://doi.org/10.1021/acs.jnatprod.9b00524
Autor:
John Xiang Li, Steven John Taylor, Mariana Margarit, Jun Li, Yu Yang, Qiang Zhang, Ingo Muegge, Melissa Hill-Drzewi, Alexander Heim-Riether, Mark Panzenbeck, Asitha Abeywardane, Zhaoming Xiong, Daniel R. Goldberg, Bennett Sandy Farmer, Gao Donghong A, Ljiljana Zuvela-Jelaska, John R. Proudfoot, Shuang Liang, Donald Souza, Lana Louise Smith-Keenan, Neil A. Farrow, Brandon Collins
Publikováno v:
ACS Omega
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
ACS Omega, Vol 6, Iss 29, Pp 18635-18650 (2021)
Here, we described the design, by fragment merging and multiparameter optimization, of selective MMP-13 inhibitors that display an appropriate balance of potency and physicochemical properties to qualify as tool compounds suitable for in vivo testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f527696acc72281bab3399c1433275
https://pubmed.ncbi.nlm.nih.gov/34337203
https://pubmed.ncbi.nlm.nih.gov/34337203
Autor:
Florian Grebien, Abootaleb Sedighi, Roman Wolfgang Fleck, Siawash Ahmar, Kay Noel, Mulu Geletu, Ji Sung Park, Elizabeth Heyes, Mohammad S. Eram, Elvin D. de Araujo, Angel Sampedro, Patrick T. Gunning, Helena Sorger, Gary Tin, Dziyana Kraskouskaya, Ruth Villalonga, Marco Herling, Jeff A O'Meara, John R. Proudfoot, Anna Orlova, Richard Moriggl, Satu Mustjoki
Publikováno v:
Cancer Research. 80:LB-108
STAT5 is a member of the signal transducer and activator of transcription family of proteins and is widely recognized as an oncogenic master regulator of hematological malignancies. To date, therapeutic approaches to attenuate aberrant activity have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbe8e55a6708a28d2dbcf72af5811f68
https://doi.org/10.1158/1538-7445.am2020-lb-108
https://doi.org/10.1158/1538-7445.am2020-lb-108
Autor:
John R. Proudfoot
Publikováno v:
The Journal of organic chemistry. 82(13)
An atom-environment complexity measure, CA, to assess local changes in complexity during synthetic transformations is described. The complexity measure is based on applying Shannon’s equation to the number and diversity of paths up to two bonds in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::544553362b31118b12bd95b7020c3dd9
https://pubmed.ncbi.nlm.nih.gov/28561574
https://pubmed.ncbi.nlm.nih.gov/28561574
Autor:
John R. Proudfoot
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(9)
An atom environment, path based approach to calculating molecular complexity is described. Based on Shannon's equation, the method transforms the number and diversity of paths emanating from an atom to an atom-complexity from which a number of molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd1306e18cc489996ddea44f2f048f01
https://pubmed.ncbi.nlm.nih.gov/28325603
https://pubmed.ncbi.nlm.nih.gov/28325603
Autor:
Paul W. Erhardt, Joerg Senn-Bilfinger, Derek R. Buckle, C. Robin Ganellin, Toshi Kobayashi, John R. Proudfoot, Thomas J. Perun
Publikováno v:
Pure and Applied Chemistry. 85:1725-1758
The evolution that has taken place in medicinal chemistry practice as a result of major advances in genomics and molecular biology arising from the Human Genome Project has carried with it an extensive additional working vocabulary that has become bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e508a5e70d8dab9d3ec466b6bd3be27b
https://doi.org/10.1351/pac-rec-12-11-23
https://doi.org/10.1351/pac-rec-12-11-23
Autor:
Xiang Li, Hidenori Takahashi, Steven S. Pullen, Stéphane De Lombaert, Asitha Abeywardane, Ming-Hong Hao, John R. Proudfoot, Anil Kumar Padyana, Brandon Collins, Leslie Martin, Daniel R. Albaugh, Steven John Taylor, Shuang Liang, Bennett Sandy Farmer, Melissa Hill-Drzewi
Publikováno v:
Journal of Medicinal Chemistry. 56:4465-4481
Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent, selective chymase inhibitors, developed using fragment-based, structure-guided linking and optim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f937968f315ebdb6231db492a5253462
https://doi.org/10.1021/jm400138z
https://doi.org/10.1021/jm400138z
Autor:
Dominique Besson, Jan E. Blanchard, Robert P. Hertzberg, Pascal Villa, John R. Proudfoot, Richard R. Neubig, Lyndon E. Llewellyn, Denis J. Crankshaw, Carol Ann Homon, John Wang, Larry A. Walker, Olivier Nosjean, Günter Gauglitz
Publikováno v:
Pure and Applied Chemistry. 83:1129-1158
Biomolecular screening is now a crucial component of the drug discovery process, and this glossary will be of use to practitioners in the field of screening and to those who interact with the screening community. The glossary contains definitions rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b6b0254b7aaf4c9ab7ccafbe335bed9
https://doi.org/10.1351/pac-rec-09-05-03
https://doi.org/10.1351/pac-rec-09-05-03
Autor:
Alison Kukulka, Ho Yin Lo, Roman Wolfgang Fleck, Raj Betageri, Mary Ann Hoermann, Usha R. Patel, Stéphane De Lombaert, Alisa K. Kabcenell, Richard H. Ingraham, Rajiv Sharma, Kirrane Thomas M, John R. Proudfoot, Neil A. Farrow, Chuk Chui Man
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6379-6383
A novel series of pyrazole sEH inhibitors is reported. Lead optimization efforts to replace the aniline core are also described. In particular, 2-pyridine, 3-pyridine and pyridazine analogs are potent sEH inhibitors with favorable CYP3A4 inhibitory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b621596bd901063820e3338d03b29798
https://doi.org/10.1016/j.bmcl.2010.09.095
https://doi.org/10.1016/j.bmcl.2010.09.095