Zobrazeno 1 - 10
of 46
pro vyhledávání: '"John R. Pehrson"'
Autor:
Ryan James Cedeno, Angela Nakauka-Ddamba, Maryam Yousefi, Stephanie Sterling, Nicolae Adrian Leu, Ning Li, John R Pehrson, Christopher Joachim Lengner
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185196 (2017)
A stem cell's epigenome directs cell fate during development, homeostasis, and regeneration. Epigenetic dysregulation can lead to inappropriate cell fate decisions, aberrant cell function, and even cancer. The histone variant macroH2A has been shown
Externí odkaz:
https://doaj.org/article/ca70c7c3afb647479940f645146dc903
Autor:
Michael O. Alberti, Brian S. White, Sang-hyun Kim, Ryan M. Nunley, Jin Shao, Cara Lunn Shirai, Lynn S. White, Monique Chavez, Jeff Bednarski, Sridhar Nonavinkere Srivatsan, John R. Pehrson, Tanzir Ahmed, Matthew J. Walter
Publikováno v:
Cell reports
SUMMARY Somatic mutations in spliceosome genes are found in ~50% of patients with myelodysplastic syndromes (MDS), a myeloid malignancy associated with low blood counts. Expression of the mutant splicing factor U2AF1(S34F) alters hematopoiesis and mR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4179f880f9c6841a7c5cdfd9d6b915
https://doi.org/10.1016/j.celrep.2021.109626
https://doi.org/10.1016/j.celrep.2021.109626
Publikováno v:
Molecular and Cellular Biology. 28:2059-2065
We show that macroH2A1 histone variants are important for repressing the expression of endogenous murine leukemia viruses (MLVs) in mouse liver. Intact MLV proviruses and proviruses with deletions in env were nearly silent in normal mouse liver and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab7c3a0819dcc305912ba19778de83f
https://doi.org/10.1128/mcb.01362-07
https://doi.org/10.1128/mcb.01362-07
Autor:
Jeffrey Shabanowitz, Emily Bernstein, Edith Heard, Robert L. Diaz, Donald F. Hunt, John R. Pehrson, Lakshmi Changolkar, Jennifer C. Chow, C. David Allis, Tara L. Muratore-Schroeder
Publikováno v:
Proceedings of the National Academy of Sciences. 105:1533-1538
Histone variants play an important role in numerous biological processes through changes in nucleosome structure and stability and possibly through mechanisms influenced by posttranslational modifications unique to a histone variant. The family of hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1261a1c882b138ed02769166fb08bb
https://doi.org/10.1073/pnas.0711632105
https://doi.org/10.1073/pnas.0711632105
Autor:
John R. Pehrson, Rugang Zhang, Tim J. Yen, Peter D. Adams, Song-Tao Liu, Wei Chen, Michael F. Bonner
Publikováno v:
Molecular and Cellular Biology. 27:949-962
Cellular information is encoded genetically in the DNA nucleotide sequence and epigenetically by the "histone code," DNA methylation, and higher-order packaging of DNA into chromatin. Cells possess intricate mechanisms to sense and repair damage to D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d71f1b48cca17c8ce0491c9215938b4
https://doi.org/10.1128/mcb.01639-06
https://doi.org/10.1128/mcb.01639-06
Autor:
Prim B. Singh, John R. Pehrson, Sergei A. Grigoryev, Tatiana Nikitina, Christopher L. Woodcock
Publikováno v:
Journal of Cell Science. 117:6153-6162
Quiescent lymphocytes have small nuclei, filled with masses of facultative heterochromatin. Upon receiving mitogenic signals, these cells undergo nuclear enlargement, chromatin decondensation, the reactivation of cell proliferation, and changes in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13b16e923f07337a758e48ac02250ff5
https://doi.org/10.1242/cs.01537
https://doi.org/10.1242/cs.01537
Autor:
Shantha K. Mahadevaiah, Eva Czirr, Sigrid Hoyer-Fender, Rebecca Radde, James M. A. Turner, John R. Pehrson, Paul S. Burgoyne
Publikováno v:
Journal of Cell Science. 117:189-198
Histone macroH2A1.2 and the murine heterochromatin protein 1, HP1β, have both been implicated in meiotic sex chromosome inactivation (MSCI) and the formation of the XY-body in male meiosis. In order to get a closer insight into the function of histo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64474407d81d1e2b9b2ab3ab5d48b1e3
https://doi.org/10.1242/jcs.00851
https://doi.org/10.1242/jcs.00851
Autor:
James M. A. Turner, Paul S. Burgoyne, Rudolf Jaenisch, Henri-Jean Garchon, Shantha K. Mahadevaiah, David J. Elliott, John R. Pehrson
Publikováno v:
Journal of Cell Science. 115:4097-4105
X chromosome inactivation occurs twice during the life cycle of placental mammals. In normal females, one X chromosome in each cell is inactivated early in embryogenesis, while in the male, the X chromosome is inactivated together with the Y chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c23be00187392ad8b5f659baa4c8913
https://doi.org/10.1242/jcs.00111
https://doi.org/10.1242/jcs.00111
Autor:
Jacqueline E. Mermoud, Anne McLaren, Kathy Hilton, Neil Brockdorff, John R. Pehrson, M. Azim Surani, Tatyana B. Nesterova
Publikováno v:
Differentiation. 69:216-225
The molecular mechanism underlying X chromosome inactivation in female mammals involves the non-coding RNAs Xist and its antisense partner Tsix. Prior to X inactivation, these RNAs are transcribed in an unstable form from all X chromosomes, both in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15045b1a92151e61f7cadbb2c200d84
https://doi.org/10.1046/j.1432-0436.2002.690415.x
https://doi.org/10.1046/j.1432-0436.2002.690415.x
Autor:
Nicolae Adrian Leu, Ning Li, Maryam Yousefi, Ryan J. Cedeno, Christopher J. Lengner, Stephanie Sterling, John R. Pehrson, Angela Nakauka-Ddamba
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 9, p e0185196 (2017)
PLoS ONE, Vol 12, Iss 9, p e0185196 (2017)
A stem cell's epigenome directs cell fate during development, homeostasis, and regeneration. Epigenetic dysregulation can lead to inappropriate cell fate decisions, aberrant cell function, and even cancer. The histone variant macroH2A has been shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b517ba8a196b62aac3d4f644c3321fa
https://doi.org/10.1371/journal.pone.0185196
https://doi.org/10.1371/journal.pone.0185196