Zobrazeno 1 - 10
of 133
pro vyhledávání: '"John R. McDonald"'
Publikováno v:
ICE 2017-13th International Conference on Engines & Vehicles Sector
Mandated pollutant emission levels are shifting light-duty vehicles towards hybrid and electric powertrains. Heavy-duty applications, on the other hand, will continue to rely on internal combustion engines for the foreseeable future. Hence there rema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd38fa8bccb139ce3b5d996b804f01b0
http://hdl.handle.net/10044/1/53778
http://hdl.handle.net/10044/1/53778
Publikováno v:
Recent Patents on Inflammation & Allergy Drug Discovery. 5:1-16
Chemokine-ligand/receptor axes play pivotal roles in a myriad of inflammatory, allergic and autoimmune diseases, as well as in the promotion of tumor growth and metastasis. Upon insult, tissue resident cells (and cancer cells in general) release a de
Autor:
John R. McDonald
Publikováno v:
Recent Patents on Inflammation & Allergy Drug Discovery. 3:177-187
Targeting cell surface antigens or receptors with lytic monoclonal antibodies and specific ligand-directed fusion proteins in order to eliminate cancer cells has been in development for at least forty years. More recently, leukocyte populations known
Autor:
Robert J. Walker, Sylvia A. de Jong, Wayne H.F. Sutherland, Maree P. McCormick, Michael J.A. Williams, John R. McDonald
Publikováno v:
Nephrology Dialysis Transplantation. 16:1251-1255
Background. Endothelial function is impaired in renal allograft recipients but the effects of antioxidant vitamin therapy on endothelial function in such patients is unknown. Methods. Thirteen renal allograft recipients were randomized to vitamin C o
Autor:
John R. McDonald, Andrew Baird, Janet E. Price, Barbara A. Sosnowski, Lois A. Chandler, L. L. Houston, Glenn F. Pierce, Sharon Lea Aukerman
Publikováno v:
International Journal of Cancer. 78:106-111
Over-expression of the epidermal growth factor receptor (EGFR) is a hallmark of numerous solid tumors, thus providing a means of selectively targeting therapeutic agents. Heparin-binding epidermal growth factor (HBEGF) binds to EGFRs with high affini
Autor:
Duk H. Min, Jennifer Cook, Andrew Farb, Sue J. Lee, Renu Virmani, Glenn F. Pierce, Zahra Parandoosh, John R. McDonald
Publikováno v:
Circulation Research. 80:542-550
Abstract Basic fibroblast growth factor (FGF2) is an important mediator of smooth muscle cell (SMC) proliferation following arterial injury that results in neointimal growth. The present study was designed to explore the effects of recombinant FGF2 l
Autor:
Gertrude L. Pease, John R. McDonald
Publikováno v:
American journal of clinical pathology. 17(3)
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1090:70-80
The gene for ciliary neurotrophic factor (CNTF) was cloned from a human genomic DNA library by screening with a DNA fragment amplified from human genomic DNA using the polymerase chain reaction. A DNA sequence coding for human CNTF was placed under c
Autor:
Bonny S.F. Choy, Liliana Perdomo, Laura M. McIntosh, Barbara K. Finck, John R. McDonald, Hongsheng Su, Michael Jack
Publikováno v:
Protein expression and purification. 66(2)
First generation chemokine ligand-Shiga A1 (SA1) fusion proteins (leukocyte population modulators, LPMs) were previously only obtained in small quantities due to the ribosomal inactivating protein properties of the SA1 moiety which inhibits protein s
Autor:
Stuart Bussell, Zahra Parandoosh, Barbara A. Sosnowski, L. L. Houston, Michael Ong, Chun Shen, John R. McDonald
Publikováno v:
Protein expression and purification. 8(1)
In order to produce sufficient quantities of fibroblast growth factor-saporin (rFGF-2-SAP) mitotoxin for preclinical evaluation in models of diseases such as cancer and restenosis, we have undertaken the large-scale expression, purification, and char