Zobrazeno 1 - 10 of 62 pro vyhledávání: '"John R. McDermott"'
1
Multicatalytic, High-Mr Endopeptidase from Postmortem Human Brain
Autor: John R. McDermott, A. M. Gibson, J. A. Biggins, A. E. Oakley
Publikováno v: Journal of Neurochemistry. 56:1509-1517
The main high molecular weight (650K) multica-talytic endopeptidase has been purified from postmortem human cerebral cortex. As in other tissues and species, this enzyme is composed of several subunits of 24-3 IK and has three distinct catalytic acti
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1105cc17e7d426bb9344d747a1c8856
https://doi.org/10.1111/j.1471-4159.1991.tb02045.x
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2
Degradation of Alzheimer's beta-amyloid protein by human cathepsin D
Autor: John R. McDermott, Alison M. Gibson
Publikováno v: Neuroreport. 7(13)
The aim of the study was to identify and characterize human brain peptidases capable of degrading Alzheimer's beta-amyloid protein. Synthetic beta-amyloid protein (1-40) was rapidly degraded by a human brain soluble fraction, optimum activity occurri
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6a54ec0440926f8154febc3d574452
https://pubmed.ncbi.nlm.nih.gov/8930981
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3
[16] Identification and characterization of central nervous system peptidase activities
Autor: John R. McDermott, Alison M. Gibson
Summary Synthetic peptides from β-amyloid precursor protein were used as substrates to identify and characterize four peptidase activities in human brain, as follows: o 1. A novel Mn 2+ -stimulated metallopeptidase with the specificity to cleave at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c11e9083ca1d2da48424d546f682cef9
https://doi.org/10.1016/s1043-9471(06)80127-8
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6
Mechanism of luteinizing hormone-releasing hormone degradation by subcellular fractions of rat hypothalamus and pituitary
Autor: J.A. Edwardson, J.A. Biggins, A.I. Smith, John R. McDermott, E.C. Griffiths
Publikováno v: Regulatory Peptides. 3:257-269
The pathway of LH-RH degradation by two subcellular fractions (a soluble fraction and a 25 000 × g particulate fraction) of rat hypothalamus, pituitary and cerebral cortex has been studied using high performance liquid chromatography and amino acid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03405b84bb3e410359e0e78f5d2a3907
https://doi.org/10.1016/0167-0115(82)90131-8
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7
A multidimensional system dynamics model of affect
Autor: John R. McDermott, Joseph R. Royce
Publikováno v: Motivation and Emotion. 1:193-224
A structural—functional perspective based on factor analysis is presented for the domain of affect. In this approach the affective system is viewed as a multivariate, hierarchically structured arrangement of affective dimensions functionally organi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b29af303997839161ecdf91c7378dee6
https://doi.org/10.1007/bf00998860
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9
Purification and Characterization of Two Soluble C1?-Activated Arginyl Aminopeptidases from Human Brain and Their Endopeptidase Action on Neuropeptides
Autor: Alison M. Gibson, David Mantle, B. Lauffart, J. A. Biggins, John R. McDermott
Publikováno v: Journal of Neurochemistry. 50:176-182
Two closely related Cl(-)-activated arginyl aminopeptidases (I and II) were purified from a soluble extract of postmortem human cerebral cortex by anion-exchange chromatography and preparative gel electrophoresis. The electrophoretic mobility of II w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6cd39f59eaed3d0e5322ee620d8ed386
https://doi.org/10.1111/j.1471-4159.1988.tb13246.x
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