Zobrazeno 1 - 10
of 132
pro vyhledávání: '"John R. Lee"'
Autor:
Liz-Audrey Kounatse Djomnang, Carol Li, Omary Mzava, Alexandre Pellan Cheng, Adrienne Chang, Joan Sesing Lenz, Manikkam Suthanthiran, John R. Lee, Darshana M. Dadhania, Iwijn De Vlaminck
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-8 (2024)
Abstract Urine is a rich source of nucleic acid biomarkers including cell-free DNA (cfDNA) and RNA for monitoring the health of kidney allografts. In this study, we aimed to evaluate whether urine filtration can serve as an alternative to the commonl
Externí odkaz:
https://doaj.org/article/e71c070c37a14af8bdc6327d4a8e55f8
Autor:
Omary Mzava, Alexandre Pellan Cheng, Adrienne Chang, Sami Smalling, Liz-Audrey Kounatse Djomnang, Joan Sesing Lenz, Randy Longman, Amy Steadman, Luis G. Gómez-Escobar, Edward J. Schenck, Mirella Salvatore, Michael J. Satlin, Manikkam Suthanthiran, John R. Lee, Christopher E. Mason, Darshana Dadhania, Iwijn De Vlaminck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The accuracy of metagenomic DNA sequencing is limited by environmental DNA contamination. Here, the authors develop and test SIFT-seq, a metagenomic DNA sequencing assay that allows to identify and remove environmental DNA contamination introduced du
Externí odkaz:
https://doaj.org/article/058d6e9e5ad3482da887a2928dfc0a0a
Autor:
Kristin Meliambro, Yanfeng Yang, Marina de Cos, Estefania Rodriguez Ballestas, Caroline Malkin, Jonathan Haydak, John R. Lee, Fadi Salem, Laura H. Mariani, Ronald E. Gordon, John M. Basgen, Huei Hsun Wen, Jia Fu, Evren U. Azeloglu, John Cijiang He, Jenny S. Wong, Kirk N. Campbell
Publikováno v:
JCI Insight, Vol 8, Iss 7 (2023)
Despite recent progress in the identification of mediators of podocyte injury, mechanisms underlying podocyte loss remain poorly understood, and cell-specific therapy is lacking. We previously reported that kidney and brain expressed protein (KIBRA),
Externí odkaz:
https://doaj.org/article/427bdc10103645eb8f284f1c9af46d1b
Autor:
Joshua B. Simpson, Josh J. Sekela, Amanda L. Graboski, Valentina B. Borlandelli, Marissa M. Bivins, Natalie K. Barker, Alicia A. Sorgen, Angie L. Mordant, Rebecca L. Johnson, Aadra P. Bhatt, Anthony A. Fodor, Laura E. Herring, Hermen Overkleeft, John R. Lee, Matthew. R. Redinbo
Publikováno v:
Gut Microbes, Vol 14, Iss 1 (2022)
Mycophenolate mofetil (MMF) is an important immunosuppressant prodrug prescribed to prevent organ transplant rejection and to treat autoimmune diseases. MMF usage, however, is limited by severe gastrointestinal toxicity that is observed in approximat
Externí odkaz:
https://doaj.org/article/d7e2a86fc68a4383913bdd253fcb47e1
Autor:
Philip Burnham, Fanny Chen, Alexandre P. Cheng, Vesh Srivatana, Lisa T. Zhang, Emmanuel Edusei, Shady Albakry, Brittany Botticelli, Xunxi Guo, Amanda Renaghan, Jeffrey Silberzweig, Darshana M. Dadhania, Joan S. Lenz, Michael Heyang, Iliyan D. Iliev, Joshua A. Hayden, Lars F. Westblade, Iwijn De Vlaminck, John R. Lee
Publikováno v:
Kidney Medicine, Vol 4, Iss 1, Pp 100383- (2022)
Rationale & Objective: Conventional culture can be insensitive for the detection of rare infections and for the detection of common infections in the setting of recent antibiotic usage. Patients receiving peritoneal dialysis (PD) with suspected perit
Externí odkaz:
https://doaj.org/article/07991f2dd4e54d8bba497216a3aa2740
Autor:
Hemant Suryawanshi, Hua Yang, Michelle Lubetzky, Pavel Morozov, Mila Lagman, Gaurav Thareja, Alicia Alonso, Carol Li, Catherine Snopkowski, Aziz Belkadi, Franco B. Mueller, John R. Lee, Darshana M. Dadhania, Steven P. Salvatore, Surya V. Seshan, Vijay K. Sharma, Karsten Suhre, Manikkam Suthanthiran, Thomas Tuschl, Thangamani Muthukumar
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
We tested the hypothesis that single-cell RNA-sequencing (scRNA-seq) analysis of human kidney allograft biopsies will reveal distinct cell types and states and yield insights to decipher the complex heterogeneity of alloimmune injury. We selected 3 b
Externí odkaz:
https://doaj.org/article/83187766d5604e109b43277b65fa3517
Autor:
Matthew Magruder, Emmanuel Edusei, Lisa Zhang, Shady Albakry, Michael J. Satlin, Lars F. Westblade, Line Malha, Christina Sze, Michelle Lubetzky, Darshana M. Dadhania, John R. Lee
Publikováno v:
Gut Microbes, Vol 12, Iss 1 (2020)
Urinary tract infection (UTI) is a common complication in kidney transplant recipients and can lead to significant morbidity and mortality. Recent evidence supports a role for the gut as a source for UTIs but little is known about the relationship be
Externí odkaz:
https://doaj.org/article/c81a178686c24c89b44d7c7a67eb670e
Autor:
John R. Lee, Michael J. Satlin
Publikováno v:
Antimicrobial Agents and Chemotherapy.
Recurrent urinary tract infections (UTIs) are common in kidney transplant recipients, and novel prevention approaches are needed. The case presented by Le et al. (Antimicrob Agents Chemother, in press) describes a patient with recurrent UTIs due to e
Publikováno v:
Curr Opin Organ Transplant
PURPOSE OF REVIEW. Research in the past decade has revealed important implications for the microbiome in human health. Studies have defined a distinct gut microbiota in kidney transplant recipients and have recently linked the microbiota to infectiou
Publikováno v:
Kidney360
Through use of high-throughput sequencing technologies, numerous studies have revealed the multifaceted role of the gut microbiota in host immunity and infection, resulting in wide-ranging implications for patients with cancer and autoimmune diseases