Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John R. Latigo"'
Autor:
Lucy Ly, John R. Griffiths, Helen Troy, Manuel Mayr, Marion Stubbs, Meg Perumal, Paul M.J. McSheehy, Kaye J. Williams, David Perrett, Monika Golinska, John R. Latigo, Adrian L. Harris, Yuen-Li Chung, Rachel Airley, Eric O. Aboagye, Xiaoke Yin
Publikováno v:
BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 198 (2011)
BMC Cancer, Vol 11, Iss 1, p 198 (2011)
Background HIF-1 deficiency has marked effects on tumour glycolysis and growth. We therefore investigated the consequences of HIF-1 deficiency in mice, using the well established Hepa-1 wild-type (WT) and HIF-1β-deficient (c4) model. These mechanism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c5f8dd8c8838a413fc38b234bcbf8d
https://ora.ox.ac.uk/objects/uuid:26b7ef33-0a0c-4870-a363-ea1361e183a2
https://ora.ox.ac.uk/objects/uuid:26b7ef33-0a0c-4870-a363-ea1361e183a2
Autor:
Fraser Mitchell, Ann L. Jackman, John R. Latigo, Radhakrishna Gopala Pillai, Eric O. Aboagye, Martin Forster, Julius Leyton, Meg Perumal, Henryk Barthel
Publikováno v:
Cancer Research. 66:8558-8564
Thymidylate synthase (EC 2.1.1.45) is a key enzyme for the de novo synthesis of DNA and as such a target for anticancer drug development. There is a need to develop noninvasive methods for assessing thymidylate synthase inhibition in tumors. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6670e69cda9562536759f7e9be23f17
https://doi.org/10.1158/0008-5472.can-06-0898
https://doi.org/10.1158/0008-5472.can-06-0898
Autor:
Paul Workman, John P. Alao, Eric O. Aboagye, Alexandra V. Stavropoulou, Marco Da Costa, Eric Lam, David M. Vigushin, Qimin He, Radhakrishna Gopala Pillai, Meg Perumal, Julius Leyton, John R. Latigo, Peter Atadja
Publikováno v:
Cancer Research. 66:7621-7629
Histone deacetylase inhibitors (HDACI) are emerging as growth inhibitory compounds that modulate gene expression and inhibit tumor cell proliferation. We assessed whether 3′-deoxy-3′-[18F]fluorothymidine–positron emission tomography ([18F]FLT-P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a93dc9dce5535d08ba3288d59a29709
https://doi.org/10.1158/0008-5472.can-05-3962
https://doi.org/10.1158/0008-5472.can-05-3962
Publikováno v:
Cancer research. 65(10)
We have assessed the potential of [18F]fluorothymidine positron emission tomography ([18F]FLT-PET) to measure early cytostasis and cytotoxicity induced by cisplatin treatment of radiation-induced fibrosarcoma 1 (RIF-1) tumor–bearing mice. Cisplatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8a2d6b3a0676ab231bbca3562040727
https://pubmed.ncbi.nlm.nih.gov/15899811
https://pubmed.ncbi.nlm.nih.gov/15899811
Autor:
John P. Alao, Lisa Sanderson, Graham W. Taylor, Raoul Charles Coombes, Eric O. Aboagye, John R. Latigo, David M. Vigushin
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(10)
Trichostatin A is a potent and specific histone deacetylase inhibitor with promising antitumor activity in preclinical models. Plasma pharmacokinetics of trichostatin A were studied following single-dose intraperitoneal administration of 80 mg/kg (hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95bbad5f796e28e710ecaf35a2312c7
https://pubmed.ncbi.nlm.nih.gov/15269190
https://pubmed.ncbi.nlm.nih.gov/15269190