Zobrazeno 1 - 10
of 76
pro vyhledávání: '"John R. Kirkpatrick"'
Publikováno v:
Journal of the American College of Surgeons. 216:800-811
Background Value is an economic utility defined by quality and cost, with the maximum benefit achieved by improving quality and reducing cost simultaneously. Health care systems are using value-based analysis to identify the best practices (BPs) that
Autor:
Joy Britten-Webb, Hasan B. Alam, Amin D. Jaskille, C. Robert Valeri, Peter Rhee, Elena Koustova, John R. Kirkpatrick, Huazhen Chen
Publikováno v:
Journal of the American College of Surgeons. 202:25-35
Background Resuscitation with racemic lactated Ringer's solution induces cellular apoptosis. This study was conducted to determine if the elimination of D-lactate isomer would attenuate apoptosis in the liver, and to investigate the possible mechanis
Autor:
Edwin A. Deitch, Amin D. Jaskille, Tetsu Yukioka, Henri R. Ford, Hasan B. Alam, Elena Koustova, William M Hanes, John R. Kirkpatrick, Peter Rhee
Publikováno v:
The Journal of Trauma: Injury, Infection, and Critical Care. 57:262-270
Resuscitation with racemic lactated Ringer's solution (containing equal amounts of D and L isomers of lactate) has been shown to induce pulmonary apoptosis. Substitution of DL-isomer lactate with ketone bodies (β-hydroxybutyrate, BHB), sodium pyruva
Autor:
Kathleen Stanton, Elena Koustova, Peter Rhee, Hasan B. Alam, John R. Kirkpatrick, Orlando Llorente
Publikováno v:
The Journal of Trauma: Injury, Infection, and Critical Care. 54:1065-1076
Background: Resuscitation fluids can have variable effects on key functions of circulating polymorphonuclear neutrophils (PMNs) such as oxidative burst, chemotaxis, and bacterial killing. We hypothesized that choice of resuscitation fluids will also
Autor:
Michael Cortelli, John L. Zapas, Lance Cohen, Donald Kim, John R. Kirkpatrick, Stanley Marks, Michele Slane, Richard Perryman, Juan F. Plate
Publikováno v:
Journal of the American College of Surgeons. 220(4)
Value-based analysis (VBA) is a management strategy used to determine changes in value (quality/cost) when a usual practice (UP) is replaced by a best practice (BP). Previously validated in clinical initiatives, its usefulness in complex systems is u
Autor:
James W. Cook, Stavros Karakozis, Donald Kim, Haydee Provido, Enrique Gongora, John R. Kirkpatrick
Publikováno v:
The American Surgeon. 67:237-242
Given that interleukin (IL)-10 (IL-10) serves as a potent down-regulator of specific proinflammatory cytokines we reasoned that its administration should improve outcome in situations in which the biological response to a severe inflammatory challeng
Autor:
Haydee Provido, Timothy L. Fitzgerald, John R. Kirkpatrick, Donald Kim, Hasan B. Alam, Wyn D. Nguyen
Publikováno v:
European Surgical Research. 32:107-110
Previous work from our laboratory demonstrated the feasibility of utilizing placental-derived collagen tissue matrix (CTM) as a bowel wall substitute. We reasoned that this technique would also be suitable in managing intestinal fistulae. To test thi
Publikováno v:
Surgery. 124:87-91
Background: Occasionally, conventional closure of an intestinal wall defect (fistula) is not possible. The development of a biologic material that can be used in this setting would solve a significant clinical problem. We hypothesized that a collagen
Publikováno v:
Journal of Surgical Research. 62:251-254
Increased concentrations of tumor necrosis factor (TNF) damage normal tissue and produce a shock-like syndrome--changes that can be prevented with anti-body-specific antisera. These findings suggest that TNF-stimulated immunity should protect normal