Zobrazeno 1 - 10
of 538
pro vyhledávání: '"John R. Helliwell"'
Autor:
John R. Helliwell, James R. Hester, Loes M. J. Kroon-Batenburg, Brian McMahon, Selina L. S. Storm
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 464-475 (2024)
The hardware for data archiving has expanded capacities for digital storage enormously in the past decade or more. The IUCr evaluated the costs and benefits of this within an official working group which advised that raw data archiving would allow gr
Externí odkaz:
https://doaj.org/article/9bf6358a114342fe9d2acd10a0ce7a57
Publikováno v:
IUCrJ, Vol 11, Iss 3, Pp 359-373 (2024)
Metal-based complexes with their unique chemical properties, including multiple oxidation states, radio-nuclear capabilities and various coordination geometries yield value as potential pharmaceuticals. Understanding the interactions between metals a
Externí odkaz:
https://doaj.org/article/6ac3ff9824fa41b3a12ec6d842afa58f
Autor:
John R. Helliwell
Publikováno v:
Structural Dynamics, Vol 11, Iss 4, Pp 040401-040401-2 (2024)
Externí odkaz:
https://doaj.org/article/4d3f753f363c4a4aae4c3000b33eca0d
Publikováno v:
IUCrJ, Vol 11, Iss 1, Pp 9-15 (2024)
Interoperability of crystallographic data with other disciplines is essential for the smooth and rapid progress of structure-based science in the computer age. Within crystallography and closely related subject areas, there is already a high level of
Externí odkaz:
https://doaj.org/article/bbacfa492770459d8d3223e1ae693eb7
Publikováno v:
Structural Dynamics, Vol 11, Iss 1, Pp 011301-011301-6 (2024)
In recent years, there has been a major expansion in digital storage capability for hosting raw diffraction datasets. Naturally, the question has now arisen as to the benefits and costs for the preservation of such raw, i.e., experimental diffraction
Externí odkaz:
https://doaj.org/article/ed82118c756f46dc87f7df034f6633fd
Autor:
Chiara Massera, John R. Helliwell
Publikováno v:
Acta Crystallographica Section E: Crystallographic Communications, Vol 79, Iss 7, Pp 580-591 (2023)
We have selected a set of ten `golden oldies', diverse crystallography articles to illustrate important moments in the development of our field of science and which form landmark papers in crystallography. They are a mixture of `science pull and tech
Externí odkaz:
https://doaj.org/article/d04b36733b9d4ddd894eda38f5528f3e
Autor:
John R. Helliwell
Publikováno v:
Structural Dynamics, Vol 10, Iss 6, Pp 061301-061301-8 (2023)
A seminal contribution in the domain of physiologically relevant biological structure and function determination was by Keith Moffat, of Cornell and latterly of the University of Chicago proposing that synchrotrons should offer the option of a Laue m
Externí odkaz:
https://doaj.org/article/3b05583c36df418ca2c13732c892bbc4
Autor:
John R. Helliwell
Publikováno v:
Current Research in Structural Biology, Vol 6, Iss , Pp 100111- (2023)
The overall diffraction precision index (DPI) of a biological macromolecule crystal structure was first described by Cruickshank in 1999. This topical review proceeds from this point and describes the subsequent elaboration of the index to individual
Externí odkaz:
https://doaj.org/article/b12893d897ee497db0a8319dceb7ae34
Publikováno v:
IUCrJ, Vol 9, Iss 2, Pp 180-193 (2022)
Radiopharmaceutical development has similar overall characteristics to any biomedical drug development requiring a compound's stability, aqueous solubility and selectivity to a specific disease site. However, organometallic complexes containing 188/1
Externí odkaz:
https://doaj.org/article/91de7430781f4efa99aea649647f421c
Autor:
Lata Govada, Emmanuel Saridakis, Sean C. Kassen, Ahmad Bin-Ramzi, Rhodri Marc Morgan, Benjamin Chain, John R. Helliwell, Naomi E. Chayen
Publikováno v:
IUCrJ, Vol 8, Iss 4, Pp 678-683 (2021)
C-C chemokine receptor 5 (CCR5) is a major co-receptor molecule used by HIV-1 to enter cells. This led to the hypothesis that stimulating an antibody response would block HIV with minimal toxicity. Here, X-ray crystallographic studies of the anti-CCR
Externí odkaz:
https://doaj.org/article/9d9a11fc926f453ebb082e66a0cece04