Zobrazeno 1 - 10
of 140
pro vyhledávání: '"John R. Hassell"'
Autor:
Yoshihiko Yamada, Kimitoshi Kohno, Walter E. Horton, Tomoyuki Miyashita, John R. Hassell, Ulf R. Rapp, John L. Cleveland
Publikováno v:
In Vitro Methods in Developmental Toxicology: ISBN: 9780429276729
In Vitro Methods in Developmental Toxicology
In Vitro Methods in Developmental Toxicology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74810c197a64e1877de6cdb6ff6db899
https://doi.org/10.1201/9780429276729-9
https://doi.org/10.1201/9780429276729-9
Publikováno v:
Experimental Eye Research. 89:218-223
Keratocytes produce the extensive stromal matrix of the cornea during the late embryonic and neonatal time periods. We propose to test the hypothesis that their biosynthetic activity declines during this process. Keratocytes were isolated from cornea
Publikováno v:
Experimental Eye Research. 87:604-611
Previously, pharmacological levels of insulin have been shown to stimulate the synthesis of normal corneal stromal collagen and proteoglycans by bovine keratocytes in culture. Here we compared insulin to physiological levels of IGF-I and found that I
Publikováno v:
Archives of Biochemistry and Biophysics. 468:244-251
Fibroblast growth factor-18 (FGF-18) has been shown to regulate the growth plate chondrocyte proliferation, hypertrophy and cartilage vascularization necessary for endochondral ossification. The heparan sulfate proteoglycan perlecan is also critical
Publikováno v:
Journal of Biological Chemistry. 280:32634-32639
Keratocytes normally express high levels of aldehyde dehydrogenase and keratocan. They proliferate and lose their keratocyte markers when they become fibroblastic during corneal wound healing. Keratocytes cultured in fetal bovine serum also become fi
Autor:
Tomas Tokar, Branavan Manoranjan, Sheila K. Singh, Kathrin Durrer, Sujeivan Mahendram, Robin Hallet, Kevin R. Brown, Nicole McFarlane, Amy Hin Yan Tong, Igor Jurisica, Chitra Venugopal, John R. Hassell, David L. Kaplan, Jason Moffat, Jean-Claude Cutz, Maleeha Qazi, Thushyant Vijaykumar, Parvez Vora, Mohini Singh, David Bakhshinyan, Naresh Murty
Publikováno v:
Neuro-Oncology. 18:vi211-vi212
Publikováno v:
Experimental Eye Research. 77:273-279
Fetal bovine serum has commonly been used to expand the population of keratocytes in culture. Tissue extracts, however, have also been used to grow other cell types. We prepared a DMEM/F12 extract of corneal stroma and compared the growth and morphol
Publikováno v:
Biochemical Journal. 361:231-241
Point mutations in the human fibroblast growth factor (FGF) receptor 3 gene (Fgfr3) produce a constitutively active receptor, which disrupts chondrocyte differentiation in the growth plate and results in skeletal dysplasias with severe shortening of
Autor:
Neil S. Silverman, Yoshihiko Yamada, William R. Wilcox, John R. Hassell, Prasanthi Govindraj, Eri Arikawa-Hirasawa, Alexander H. Le
Publikováno v:
Nature Genetics. 27:431-434
Perlecan is a large heparan sulfate (HS) proteoglycan present in all basement membranes and in some other tissues such as cartilage1,2, and is implicated in cell growth and differentiation3,4,5. Mice lacking the perlecan gene6,7 (Hspg2) have a severe
Publikováno v:
Cellular and Molecular Life Sciences CMLS. 57:859-863
The leucine-rich proteoglycans (also known as "small, leucine-rich proteoglycans," or SLRPs) lumican and decorin are thought to be involved in the regulation of collagen fibril assembly. Preparation of these proteoglycans in chemical amounts without