BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

Autor: Jenny M. Hoffmann, John R. Grünberg, Ann Hammarstedt, Tobias Kroon, Thomas U. Greiner, Stefanie Maurer, Ivet Elias, Vilborg Palsdottir, Fatima Bosch, Jeremie Boucher, Shahram Hedjazifar, Ulf Smith

Publikováno v: Molecular Metabolism, Vol 32, Iss , Pp 15-26 (2020)

Objective: Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WA

Externí odkaz: https://doaj.org/article/f9ddf0eaf4ad46ecababbbec31f4fdd4

BMP4 gene therapy enhances insulin sensitivity but not adipose tissue browning in obese mice

Autor: Vilborg Palsdottir, Ann Hammarstedt, Thomas U. Greiner, Ivet Elias, Stefanie Maurer, Tobias Kroon, Fatima Bosch, Shahram Hedjazifar, John R. Grünberg, Jenny M. Hoffmann, Jeremie Boucher, Ulf Smith

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 32, Iss, Pp 15-26 (2020)

Objective Bone morphogenetic protein 4 (BMP4) adeno-associated viral vectors of serotype 8 (AAV8) gene therapy targeting the liver prevents the development of obesity in initially lean mice by browning the large subcutaneous white adipose tissue (WAT

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c229035283332b81cbcc4ac30ce3089
http://europepmc.org/articles/PMC6933264

Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

Autor: Alan Saghatelian, John J. Castellot, Johannes Elvin, Barbara B. Kahn, Lan Wei, Ann Hammarstedt, Claes Ohlsson, Sofia Movérare-Skrtic, Fredrik Bäckhed, Shahram Hedjazifar, Annika Nerstedt, Louise Mannerås Holm, Ismail Syed, Fatima Bosch, Jenny M. Hoffmann, John R. Grünberg, Ulf Smith, Lachmi Jenndahl

Publikováno v: Scientific Reports
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Grünberg, J R, Hoffmann, J M, Hedjazifar, S, Nerstedt, A, Jenndahl, L, Elvin, J, Castellot, J, Wei, L, Movérare-Skrtic, S, Ohlsson, C, Holm, L M, Bäckhed, G F, Syed, I, Bosch, F, Saghatelian, A, Kahn, B B, Hammarstedt, A & Smith, U 2017, ' Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance ', Scientific Reports, vol. 7, 43515 . https://doi.org/10.1038/srep43515

WISP2 is a novel adipokine, most highly expressed in the adipose tissue and primarily in undifferentiated mesenchymal cells. As a secreted protein, it is an autocrine/paracrine activator of canonical WNT signaling and, as an intracellular protein, it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049d8ccd87993b9a6189f6501dc9c85c
http://europepmc.org/articles/PMC5327486

WISP2 regulates preadipocyte commitment and PPARγ activation by BMP4

Autor: Birgit Gustafson, Ann Hammarstedt, Dominique Langin, Silvia Gogg, Ulf Smith, Markku Laakso, Vladimir Stich, Lachmi Jenndahl, Shahram Hedjazifar, Eva Klimcakova, John R. Grünberg

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 110(7)

Inability to recruit new adipose cells following weight gain leads to inappropriate enlargement of existing cells (hypertrophic obesity) associated with inflammation and a dysfunctional adipose tissue. We found increased expression of WNT1 inducible

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::534c02d2713f8a82ff9050b6f0bbe323
https://pubmed.ncbi.nlm.nih.gov/23359679