Výsledky vyhledávání - "John R. Fabian"

Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle

Autor: Leonard S. Jefferson, Scot R. Kimball, John R. Fabian

Publikováno v: The International Journal of Biochemistry & Cell Biology. 31:191-200

Eukaryotic initiation factor eIF2B is a guanine nucleotide exchange protein involved in regulation of translation initiation. Phosphorylation of the epsilon-subunit is thought to be important in insulin-mediated changes in eIF2B activity. However, el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356cff5a75058fad4960fd68298f950d
https://doi.org/10.1016/s1357-2725(98)00141-1

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Regulation of Guanine Nucleotide Exchange through Phosphorylation of Eukaryotic Initiation Factor eIF2α

Autor: John R. Fabian, Graham D. Pavitt, Leonard S. Jefferson, Scot R. Kimball, Alan G. Hinnebusch

Publikováno v: Journal of Biological Chemistry. 273:12841-12845

The guanine nucleotide exchange activity of eIF2B plays a key regulatory role in the translation initiation phase of protein synthesis. The activity is markedly inhibited when the substrate, i. e. eIF2, is phosphorylated on Ser51 of its alpha-subunit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::500ea88eb56979cf9451b1c1724ae14e
https://doi.org/10.1074/jbc.273.21.12841

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Subunit Assembly and Guanine Nucleotide Exchange Activity of Eukaryotic Initiation Factor-2B Expressed in Sf9 Cells

Autor: Leonard S. Jefferson, John R. Fabian, Nina K. Heinzinger, Scot R. Kimball

Publikováno v: Journal of Biological Chemistry. 272:12359-12365

Eukaryotic initiation factor-2B (eIF-2B) is a guanine nucleotide exchange factor (GEF) that plays a key role in the regulation of protein synthesis. In this study, we have used the baculovirus-infected Sf9 insect cell system to express and characteri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e37e2d7684be5c9aa9792ba82d2fb833
https://doi.org/10.1074/jbc.272.19.12359

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Role of Proximal Promoter Elements in Regulation of Renin Gene Transcription

Autor: J. Pablo Abonia, Colleen M. Kane, Curt D. Sigmund, Kenneth W. Gross, John R. Fabian, Nenad Petrovic, Craig A. Jones, Thomas A. Black, John A. Loudon

Publikováno v: Journal of Biological Chemistry. 271:22499-22505

Mouse As4.1 cells, obtained after transgene-targeted oncogenesis to induce neoplasia in renal renin-expressing cells, express high levels of renin mRNA from the endogenous Ren-1(c) gene. We have used these cells to characterize the role of the Ren-1(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b40dc748504b266d961b62d5947c13a
https://doi.org/10.1074/jbc.271.37.22499

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The Activity of D-raf in Torso Signal Transduction Is Altered by Serine Substitution, N-Terminal Deletion, and Membrane Targeting

Autor: John R. Fabian, Linda Ambrosio, Deborah K. Morrison, Kwang-Hyun Baek, Frank Sprenger

Publikováno v: Developmental Biology. 175(2):191-204

TheRaffamily of serine/threonine kinases are essential components in many receptor tyrosine kinase-mediated signal transduction pathways. Here, we analyze the function of D-raf in the Torso (Tor) pathway required to specify cellular fates at the embr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c447aef671fc37c1130dc9c8a9dab11

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Expression of the Mouse Ren-1 Gene in the Coagulating Gland: Localization and Regulation1

Autor: John R. Fabian, Colleen M. Kane, Kenneth J. Abel, Kenneth W. Gross

Publikováno v: Biology of Reproduction. 48:1383-1394

The components of the renin-angiotensin system have been detected in various reproductive tissues of mammals including the testis, epididymis, ovary, and placenta. Using Northern blot and in situ hybridization analyses, we detected abundant levels of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba11876dedc01678f7b52dbb8e779589
https://doi.org/10.1095/biolreprod48.6.1383

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Expression and regulation of the renin gene

Autor: Curt D. Sigmund, Kenneth W. Gross, John R. Fabian

Publikováno v: Trends in Cardiovascular Medicine. 2:237-245

Elucidating the expression and regulation of the renin gene has been the focus of intense investigation because of its participation in the renin-angiotensin system and its links to hypertension. Since the cloning of the first complementary DNA (cDNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c9bd31ed57daaa3f123dc29c701ea9
https://doi.org/10.1016/1050-1738(92)90031-m

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Tissue and cell specific expression of a renin promoter-reporter gene construct in transgenic mice

Autor: Kenneth W. Gross, John R. Fabian, Curt D. Sigmund, John J. Mullins, Craig A. Jones

Publikováno v: Biochemical and Biophysical Research Communications. 170:344-350

The tissue specific expression of a fusion transgene consisting of 4.6 kb of Ren-2 5' flanking sequence and the SV40 T antigen viral oncogene was analyzed by northern hybridization and immunocytochemistry. Among the 10 tissues examined, endogenous re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b59999ba82040cc4150107ebbcbf0840
https://doi.org/10.1016/0006-291x(90)91280-6

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