Zobrazeno 1 - 10
of 14
pro vyhledávání: '"John R. D. Dawson"'
Autor:
Shahin Shams, Joseph M. Martinez, John R. D. Dawson, Juan Flores, Marina Gabriel, Gustavo Garcia, Amanda Guevara, Kaitlin Murray, Noah Pacifici, Maxemiliano V. Vargas, Taylor Voelker, Johannes W. Hell, Judith F. Ashouri
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with
Externí odkaz:
https://doaj.org/article/0814baba26314b3f86a057e781baaacc
Autor:
Yanxiao Han, John R. D. Dawson, Kevin R. DeMarco, Kyle C. Rouen, Slava Bekker, Vladimir Yarov-Yarovoy, Colleen E. Clancy, Yang K. Xiang, Igor Vorobyov
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 120, iss 10
G protein-coupled receptors (GPCRs) represent the largest group of membrane receptors for transmembrane signal transduction. Ligand-induced activation of GPCRs triggers G protein activation followed by various signaling cascades. Understanding the st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc728f2ef17ee1e1039d0135f492c272
https://escholarship.org/uc/item/07j4d27h
https://escholarship.org/uc/item/07j4d27h
Autor:
Slava Bekker, Mao Tsuen Jeng, Heike Wulff, Colleen E. Clancy, Van A. Ngo, Pei Chi Yang, Kazuharu Furutani, James C. Fettinger, Vladimir Yarov-Yarovoy, Vikrant Singh, Igor Vorobyov, Sergei Y. Noskov, Jon T. Sack, Kevin R. DeMarco, John R. D. Dawson
Publikováno v:
Journal of Molecular and Cellular Cardiology. 158:163-177
Drug isomers may differ in their proarrhythmia risk. An interesting example is the drug sotalol, an antiarrhythmic drug comprising d- and l- enantiomers that both block the hERG cardiac potassium channel and confer differing degrees of proarrhythmic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca30f9d545d92906b5d654c03d7da00
https://doi.org/10.1016/j.yjmcc.2021.05.015
https://doi.org/10.1016/j.yjmcc.2021.05.015
Autor:
Judith F. Ashouri, Taylor L. Voelker, Noah Pacifici, Marina H. Gabriel, Kaitlin Murray, Shahin Shams, Juan C. Flores, John R. D. Dawson, Amanda Guevara, Gustavo Garcia, Joseph M. Martinez, Maxemiliano V. Vargas, Johannes W. Hell
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology, Vol 12 (2021)
Rheumatoid arthritis (RA) is a debilitating autoimmune disease with grave physical, emotional and socioeconomic consequences. Despite advances in targeted biologic and pharmacologic interventions that have recently come to market, many patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e0f70ddd5e8d9cdc21e8cc7221c4e8
Autor:
Colleen E. Clancy, Slava Bekker, Igor Vorobyov, Kevin R. DeMarco, John R. D. Dawson, Parya Aghasafari, Pei Chi Yang, Mao Tsuen Jeng, Vladimir Yarov-Yarovoy, Sergei Y. Noskov
Publikováno v:
Circ Res
Circulation research, vol 126, iss 8
Circulation research, vol 126, iss 8
Rationale: Drug-induced proarrhythmia is so tightly associated with prolongation of the QT interval that QT prolongation is an accepted surrogate marker for arrhythmia. But QT interval is too sensitive a marker and not selective, resulting in many us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606ba9e912830203c6a7df20a1cf696d
https://europepmc.org/articles/PMC7155920/
https://europepmc.org/articles/PMC7155920/
Autor:
Igor Vorobyov, Van A. Ngo, John R. D. Dawson, Pei Chi Yang, Colleen E. Clancy, Sergei Y. Noskov, Kazuharu Furutani, Kevin R. DeMarco, Slava Bekker, Vladimir Yarov-Yarovoy, Jon T. Sack
Publikováno v:
Biophysical Journal. 120:245a-246a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e68dd9a5c4a979b940563395944fceeb
https://doi.org/10.1016/j.bpj.2020.11.1605
https://doi.org/10.1016/j.bpj.2020.11.1605
Autor:
Kevin R. DeMarco, Colleen E. Clancy, Pei Chi Yang, Slava Bekker, Vladimir Yarov-Yarovoy, John R. D. Dawson, Igor Vorobyov
Publikováno v:
Biophysical Journal. 118:115a-116a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10c3189161efe368538ae934c8509397
https://doi.org/10.1016/j.bpj.2019.11.774
https://doi.org/10.1016/j.bpj.2019.11.774
Autor:
Sergei Y. Noskov, Pei Chi Yang, Kevin R. DeMarco, Igor Vorobyov, Colleen E. Clancy, John R. D. Dawson, Van A. Ngo, Slava Bekker, Vladimir Yarov-Yarovoy
Current methods for assessing safety pharmacology in the context of cardiac arrhythmia risk are unable to distinguish between drugs that cause cardiac rhythm disturbances and benign drugs. Drugs deemed likely to be unsafe share the common property of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a148a4d2ea89932a1d2d56d96eee78a
Autor:
Igor Vorobyov, Pei Chi Yang, Kevin R. DeMarco, Slava Bekker, Vladimir Yarov-Yarovoy, John R. D. Dawson
Publikováno v:
Biophysical Journal. 120:123a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec36cae7f3a777a6f4da6196252f9e7
https://doi.org/10.1016/j.bpj.2020.11.959
https://doi.org/10.1016/j.bpj.2020.11.959
Autor:
Kevin R. DeMarco, Igor Vorobyov, Vladimir Yarov-Yarovoy, John R. D. Dawson, Colleen E. Clancy, Slava Bekker
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab23bb1a72131ca8ab2ef9f2ba2cc020
https://doi.org/10.1096/fasebj.2020.34.s1.07032
https://doi.org/10.1096/fasebj.2020.34.s1.07032