Výsledky vyhledávání - "John R. Cosgrove"

Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus

Autor: John R. Cosgrove, Erin S. McCallum, J.P. Sherry, Bharat Chandramouli, Denina B.D. Simmons, Sigal Balshine

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Scientific Reports

Pharmaceuticals and personal care products (PPCPs) have been found in wastewater treatment plant (WWTP) effluents and their recipient watersheds. To assess the potential of WWTP effluents to alter fish behaviour, we caged male goldfish (Carassius aur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71c15e5da26df5777c85b1279887054c
https://doaj.org/article/81594d76827544428b08fa46a711e922

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Altered expression of metabolites and proteins in wild and caged fish exposed to wastewater effluents in situ

Autor: Jason E. Miller, J.P. Sherry, Sigal Balshine, Erin S. McCallum, Bharat Chandramouli, Denina B.D. Simmons, John R. Cosgrove, S. Clarence

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports

Population growth has led to increased global discharges of wastewater. Contaminants that are not fully removed during wastewater treatment, such as pharmaceuticals and personal care products (PPCPs), may negatively affect aquatic ecosystems. PPCPs c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa0e918289bb9b8adbb207682c0c44b8
http://link.springer.com/article/10.1038/s41598-017-12473-6

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A multi-omic approach to elucidate low-dose effects of xenobiotics in zebrafish ( Danio rerio ) larvae

Autor: Jonathan P. Benskin, Heather Butler, Susie S.Y. Huang, Bharat Chandramouli, Nik Veldhoen, Caren C. Helbing, John R. Cosgrove

Publikováno v: Aquatic Toxicology. 182:102-112

Regulatory-approved toxicity assays such as the OECD Fish Embryo Toxicity Assay (TG236) allow correlation of chemical exposure to adverse morphological phenotypes. However, these assays are ineffective in assessing sub-lethal (i.e. low-dose) effects,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::744de20aa27ad5a35f8916fe536071d9
https://doi.org/10.1016/j.aquatox.2016.11.016

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Xenobiotics Produce Distinct Metabolomic Responses in Zebrafish Larvae (Danio rerio)

Autor: Heather Butler, Bharat Chandramouli, John R. Cosgrove, Jonathan P. Benskin, Susie S.Y. Huang, Caren C. Helbing

Publikováno v: Environmental Science & Technology. 50:6526-6535

Sensitive and quantitative protocols for characterizing low-dose effects are needed to meet the demands of 21st century chemical hazard assessment. To test the hypothesis that xenobiotic exposure at environmentally relevant concentrations produces sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18e47647688c7624fa9219ada5809600
https://doi.org/10.1021/acs.est.6b01128

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Concentrations of legacy and new contaminants are related to metabolite profiles in Hudson Bay polar bears

Autor: Bharat Chandramouli, Robert J. Letcher, Adam D. Morris, John R. Cosgrove, M. Dyck

Publikováno v: Environmental research. 168

There are very few metabolomics assessments based on field accumulated, uncontrolled contaminant exposures in wildlife, particularly in the Arctic. In the present study, targeted metabolomics and contaminant data were analyzed together to assess pote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0ac1f9db41edf17bb4eafe63d6bfee
https://pubmed.ncbi.nlm.nih.gov/30384230

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Multivariate statistical analysis of metabolomics profiles in tissues of polar bears (Ursus maritimus) from the Southern and Western Hudson Bay subpopulations

Autor: Bharat Chandramouli, M. Dyck, Robert J. Letcher, John R. Cosgrove, Aaron T. Fisk, Adam D. Morris

Publikováno v: Great Lakes Institute for Environmental Research Publications

Polar bears (Ursus maritimus) are apex predators of the Arctic, which exposes them to an array of natural and anthropogenic stress factors. Metabolomics analysis profiles endogenous metabolites that reflect the response of biological systems to stimu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec49cef5b15a4e3c6f41316da6e8951
https://scholar.uwindsor.ca/glierpub/322

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Omics for aquatic ecotoxicology: Control of extraneous variability to enhance the analysis of environmental effects

Autor: Jonathan P. Benskin, Bernard P. Duncker, Drew R. Ekman, Denina B.D. Simmons, James P. Sherry, Christopher J. Martyniuk, John R. Cosgrove

Publikováno v: Environmental Toxicology and Chemistry. 34:1693-1704

There are multiple sources of biological and technical variation in a typical ecotoxicology study that may not be revealed by traditional endpoints but that become apparent in an omics dataset. As researchers increasingly apply omics technologies to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::976147372857ac594b3bc1bfb4944a43
https://doi.org/10.1002/etc.3002

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Sorption of per- and polyfluoroalkyl substances (PFASs) on filter media: Implications for phase partitioning studies

Autor: John R. Cosgrove, Jonathan P. Benskin, Bharat Chandramouli, M. Coreen Hamilton

Publikováno v: Environmental Toxicology and Chemistry. 34:30-36

Per- and polyfluoroalkyl substances (PFASs), including perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), are ubiquitous in the environment. Investigations into their fate and potential phase-partitioning behavior require separati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1350332befe81589d0cc21efd7840b1
https://doi.org/10.1002/etc.2751

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Distinctive Metabolite Profiles in In-Migrating Sockeye Salmon Suggest Sex-Linked Endocrine Perturbation

Autor: Cory Dubetz, Caren C. Helbing, Jun Liu, Michael G. Ikonomou, Nik Veldhoen, John R. Cosgrove, Jonathan P. Benskin

Publikováno v: Environmental Science & Technology. 48:11670-11678

The health of Skeena River Sockeye salmon (Onchorhychus nerka) has been of increasing concern due to declining stock returns over the past decade. In the present work, in-migrating Sockeye from the 2008 run were evaluated using a mass spectrometry-ba

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c9d96538e48f631786571e4e7d7098
https://doi.org/10.1021/es503266x

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Fate of triclosan in tertiary wastewater treatment: chlorination

Autor: Thomas J. Fikslin, Million B. Woudneh, A. Ronald MacGillivray, John R. Cosgrove, Jennifer Pape, Richard Grace

Publikováno v: Water Quality Research Journal. 48:333-343

Behavior of the antimicrobial triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) was investigated under laboratory chlorination conditions and in a wastewater treatment plant discharging 380 million liters daily to the Delaware River, USA. Reactions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::83705936a90a21b1068bdf2e5216a84a
https://doi.org/10.2166/wqrjc.2013.108

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