Zobrazeno 1 - 10 of 19 pro vyhledávání: '"John R. Ciallella"'
1
In vivo phenotypic screening: clinical proof of concept for a drug repositioning approach
Autor: Andrew G. Reaume, John R. Ciallella
Publikováno v: Drug Discovery Today: Technologies. 23:45-52
In vivo phenotypic screening and drug repositioning are strategies developed as alternatives to underperforming hypothesis-driven molecular target based drug discovery efforts. This article reviews examples of drugs identified by phenotypic observati
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b547ce7aaef4beb60cf76d16c28e4792
https://doi.org/10.1016/j.ddtec.2017.04.001
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4
Caspase inhibition therapy abolishes brain trauma-induced increases in Aβ peptide: Implications for clinical outcome
Autor: Dorothy G. Flood, Caroline E. Hope, Barbara A. Isanski, Steven T. DeKosky, Milos D. Ikonomovic, William R. Paljug, John R. Ciallella, Robert S. B. Clark, Eric E. Abrahamson
Publikováno v: Experimental Neurology. 197:437-450
The detrimental effects of traumatic brain injury (TBI) on brain tissue integrity involve progressive axonal damage, necrotic cell loss, and both acute and delayed apoptotic neuronal death due to activation of caspases. Post-injury accumulation of am
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3402293974fd8955a3e8e567726a58ab
https://doi.org/10.1016/j.expneurol.2005.10.011
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5
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
Autor: Robert S. B. Clark, Steven T. DeKosky, John R. Ciallella, John Q. Trojanowski, Milos D. Ikonomovic, Kunihiro Uryu, Stephen R. Wisniewski, Donald W. Marion, Virginia M.-Y. Lee, Eric E. Abrahamson
Publikováno v: Experimental Neurology. 190:192-203
Traumatic brain injury (TBI) is a risk factor for the development of Alzheimer's disease (AD). This immunohistochemical study determined the extent of AD-related changes in temporal cortex resected from individuals treated surgically for severe TBI.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3e6ec31ea56a77616b9f1294387386d
https://doi.org/10.1016/j.expneurol.2004.06.011
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6
Differential Effects of Traumatic Brain Injury on Vesicular Acetylcholine Transporter and M2Muscarinic Receptor mRNA and Protein in Rat
Autor: John R. Ciallella, Hong Qu Yan, Steven T. DeKosky, Lifang Shao, C. E. Dixon, B. M. Wolfson, Xiecheng Ma, Donald W. Marion
Publikováno v: Journal of Neurotrauma. 16:555-566
Experimental traumatic brain injury (TBI) produces cholinergic neurotransmission deficits that may contribute to chronic spatial memory deficits. Cholinergic neurotransmission deficits may result from presynaptic alterations in the storage and releas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d43eaa73db76320a281a9e30d5f6332f
https://doi.org/10.1089/neu.1999.16.555
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7
Thrombin Induces Surface and Intracellular Secretion of Amyloid Precursor Protein from Human Endothelial Cells
Autor: John R. Ciallella, Virginia Smith-Swintosky, Joseph P. McGillis, Helmer Figueiredo
Publikováno v: Thrombosis and Haemostasis. 81:630-637
SummaryThrombin, a major coagulant and inflammatory mediator, was shown to regulate amyloid precursor protein (APP) secretion. APP is the protein from which the amyloid beta peptide (Aß) is derived. Aß forms the core of vascular and cerebral plaque
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::da684580570556e9a228156fc1126567
https://doi.org/10.1055/s-0037-1614537
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8
Chronic Effects of Traumatic Brain Injury on Hippocampal Vesicular Acetylcholine Transporter and M2Muscarinic Receptor Protein in Rats
Autor: Hong Qu Yan, C. E. Dixon, Steven T. DeKosky, Donald W. Marion, John R. Ciallella, B. M. Wolfson, Xiecheng Ma
Publikováno v: Experimental Neurology. 152:11-19
Experimental traumatic brain injury (TBI) produces cholinergic neurotransmission deficits that may contribute to chronic spatial memory deficits. Cholinergic neurotransmission deficits may be due to presynaptic alterations in the storage and release
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590baf30a7f5851d66edd5dc13540c6c
https://doi.org/10.1006/exnr.1998.6831
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9
Characterization of a calcitonin gene-related peptide (CGRP) receptor on mouse bone marrow cells
Autor: Vidya Rangnekar, Joseph P. McGillis, John R. Ciallella, Melisa W. Mullins
Publikováno v: Regulatory Peptides. 49:65-72
Calcitonin gene-related peptide, (CGRP), a vasoactive neuropeptide, is found throughout the peripheral nervous system, and CGRP receptors are present on mature lymphocytes. The current studies describe a CGRP receptor on isolated mouse bone marrow ce
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d9293cd6dd6cfac8b01ddd5739794f
https://doi.org/10.1016/0167-0115(93)90385-l
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10
Modulation of B Lymphocyte Differentiation by Calcitonin Gene-Related Peptide (CGRP)
Autor: Vidya Rangnekar, S. Humphreys, John R. Ciallella, Joseph P. McGillis
Publikováno v: Cellular Immunology. 150:405-416
Calcitonin gene-related peptide (CGRP) is a 37-amino acid neuropeptide found in both peripheral and central neurons and in certain endocrine tissues. Previous studies have identified specific high-affinity CGRP receptors on normal T and B cells and h
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd7f0cf7a34a6ec274d05faee7c89592
https://doi.org/10.1006/cimm.1993.1208
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