Zobrazeno 1 - 10
of 151
pro vyhledávání: '"John R. Cann"'
Publikováno v:
International Journal of Peptide and Protein Research. 35:258-262
A precipitin effect has been observed with mixtures of cerebroside sulfate and the neuropeptide substance P. This phenomenon is attributed to multivalency of the lipid due to its existence in micellar form, and to bivalency of substance P. One of tho
Autor:
John R. Cann
Publikováno v:
Electrophoresis. 19:1336-1340
Incorporation of the dispersion coefficient into the theory of the mobility-shift assay for DNA-protein complexes was highly successful largely due to increased mathematical rigor. A model simulating electrophoretic migration of DNA across the phase
Publikováno v:
Biochemistry and Cell Biology. 76:257-266
Most physiological processes are regulated by peptides that perform their functions by interacting with specific receptors on cells. Specific conformations of the peptides are required for correct interactions to take place, and a knowledge of the bi
Autor:
John R. Cann
Publikováno v:
Electrophoresis. 19:127-141
The theory of mass transport coupled to reversible macromolecular interactions under chemical kinetic control forms the basis for computer simulation of the electrophoretic mobility-shift behavior of protein-DNA complexes. Model systems include (i) s
Publikováno v:
Biopolymers. 42:521-535
Extensive proton magnetic resonance experiments were carried out on three bradykinin peptide antagonists B-9430, B-9436, and B-9858 in aqueous solutions as well as in sodium dodecylsulphate micelles (B-9430 and B-9436) and CD3OH/H2O (60%/40%) mixture
Publikováno v:
Journal of Medicinal Chemistry. 39:1281-1292
A detailed NMR, CD, fluorometry, and molecular modeling study of a novel bradykinin antagonist B-9340, containing a novel amino acid D-Igl (alpha-(2-indanyl)glycine) at position 7, was carried out. The sequence of B-9340 is D-Arg0-Arg1-Pro2-Hyp3-Gly4
Publikováno v:
Electrophoresis. 16:881-887
Complexes of an 88 bp DNA and the HU protein were studied by both experimental and theoretical electrophoretic mobility-shift analyses. Experimental analysis defined the stoichiometry of binding and estimated an apparent intrinsic dissociation consta
Publikováno v:
Biochemistry. 33:10185-10190
Theoretical and experimental studies have illustrated a potential source of error in sedimentation coefficients obtained by sucrose density gradient centrifugation of proteins undergoing reversible self-association. The error stems from the excluded
Publikováno v:
Journal of Chromatography A. 659:267-273
An improved method is described for evaluation of the dissociation rate constant for the solute—matrix interaction from affinity chromatographic elution profiles in which the flow-rate dependence of the variance reflects the combined effects of che
Publikováno v:
Journal of Biomolecular Structure and Dynamics. 11:169-179
Bradykinin (BK) is a peptide hormone with sequence Arg1-Pro2-Pro3-Gly4-Phe5-Ser6-Pro7-Phe8-Arg9 and has been implicated in a multitude of pathophysiological processes such as the ability to lower systemic blood pressure and stimulate pain. Bulky, bet