Zobrazeno 1 - 10
of 119
pro vyhledávání: '"John R. Bethea"'
Autor:
Kayla L. Nguyen, Ishaan J. Bhatt, Shruti Gupta, Nazaf Showkat, Kathryn A. Swanson, Roman Fischer, Roland E. Kontermann, Klaus Pfizenmaier, Valerie Bracchi-Ricard, John R. Bethea
Publikováno v:
Brain Research Bulletin, Vol 207, Iss , Pp 110885- (2024)
Multiple sclerosis (MS), a demyelinating autoimmune disease of the central nervous system (CNS), predominately affects females compared to males. Tumor necrosis factor (TNF), a pro-inflammatory cytokine, signaling through TNF receptor 1 contributes t
Externí odkaz:
https://doaj.org/article/667057d00d2a42bdb40ed215236bb75d
Autor:
Yifan Lu, Yu Sun, Keman Xu, Fatma Saaoud, Ying Shao, Charles Drummer, Sheng Wu, Wenhui Hu, Jun Yu, Satya P. Kunapuli, John R. Bethea, Roberto I. Vazquez-Padron, Jianxin Sun, Xiaohua Jiang, Hong Wang, Xiaofeng Yang
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
To determine whether aorta becomes immune organ in pathologies, we performed transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells and made the following findings: 1) 53.7% out of 21,306 human protein genes are cl
Externí odkaz:
https://doaj.org/article/1977082e18d2438295044771a71d4404
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Multiple Sclerosis (MS) is a debilitating autoimmune disease often accompanied by severe chronic pain. The most common type of pain in MS, called neuropathic pain, arises from disease processes affecting the peripheral and central nervous systems. It
Externí odkaz:
https://doaj.org/article/d037dd935eb94c6787ff23a2dbc433bf
Autor:
John R. Bethea, Roman Fischer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Chronic neuropathic pain (CNP) is caused by a lesion or disease of the somatosensory nervous system. It affects ~8% of the general population and negatively impacts a person's level of functioning and quality of life. Its resistance to available pain
Externí odkaz:
https://doaj.org/article/46037cc2e0ab48699ee3e8af11a0dc20
Autor:
Tanja Padutsch, Maksim Sendetski, Carina Huber, Nathalie Peters, Klaus Pfizenmaier, John R. Bethea, Roland E. Kontermann, Roman Fischer
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Autoimmune diseases are caused by uncontrolled endogenous immune responses against healthy cells. They may develop due to an impaired function of regulatory T cells (Tregs), which normally suppress self-specific effector immune cells. Interleukin 2 (
Externí odkaz:
https://doaj.org/article/49fe5861275a40c683d881ca1fc38305
Publikováno v:
Chinese Journal of Traumatology, Vol 21, Iss 3, Pp 125-136 (2018)
Traumatic injury of the central nervous system (CNS) including brain and spinal cord remains a leading cause of morbidity and disability in the world. Delineating the mechanisms underlying the secondary and persistent injury versus the primary and tr
Externí odkaz:
https://doaj.org/article/a2d9f30c8f844813a723b7b8b19cdfd2
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-11 (2018)
Abstract Background Spinal cord injury (SCI) disrupts essential neuroimmune communication, leading to severe immune depression. Previous studies confirmed immune dysfunction in mice with chronic SCI and following high thoracic level injury where symp
Externí odkaz:
https://doaj.org/article/9ca224a821964339b1b874b280c45364
Autor:
Xiao Xiao, Raj Putatunda, Yonggang Zhang, Priya V. Soni, Fang Li, Ting Zhang, Mingyang Xin, Jin Jun Luo, John R. Bethea, Yuan Cheng, Wenhui Hu
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-14 (2018)
Abstract Background Lymphotoxin (LT) is a lymphokine mainly expressed in lymphocytes. LTα binds one or two membrane-associated LTβ to form LTα2β1 or LTα1β2 heterotrimers. The predominant LTα1β2 binds to LTβ receptor (LTβR) primarily express
Externí odkaz:
https://doaj.org/article/f2f04a7031ef4acdba59f2b0dfaf5a39
Autor:
Roman Fischer, Jessica Marsal, Cristiano Guttà, Stephan A. Eisler, Nathalie Peters, John R. Bethea, Klaus Pfizenmaier, Roland E. Kontermann
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Tumor necrosis factor receptor 2 (TNFR2) is known to mediate immune suppression and tissue regeneration. Interestingly, the transmembrane form of tumor necrosis factor (tmTNF) is necessary to robustly activate TNFR2. To characterize the stoi
Externí odkaz:
https://doaj.org/article/5426e79d6acc4127b9912c15e577861b
Publikováno v:
ASN Neuro, Vol 5 (2013)
CVD (cardiovascular disease) represents a leading cause of mortality in chronic SCI (spinal cord injury). Several component risk factors are observed in SCI; however, the underlying mechanisms that contribute to these risks have not been defined. Cen
Externí odkaz:
https://doaj.org/article/387eff3247ef4821b327db82c783229e