Zobrazeno 1 - 10
of 36
pro vyhledávání: '"John R. Bankston"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel isoforms, HCN1-HCN4, are expressed throughout the body, where they contr
Externí odkaz:
https://doaj.org/article/860b369fcfe04012bb1d32cee00eee5c
Autor:
Colin H Peters, Rohit K Singh, Avery A Langley, William G Nichols, Hannah R Ferris, Danielle A Jeffrey, Catherine Proenza, John R Bankston
Publikováno v:
eLife, Vol 12 (2024)
Lymphoid restricted membrane protein (LRMP) is a specific regulator of the hyperpolarization-activated cyclic nucleotide-sensitive isoform 4 (HCN4) channel. LRMP prevents cAMP-dependent potentiation of HCN4, but the interaction domains, mechanisms of
Externí odkaz:
https://doaj.org/article/555c3982dc0b43a5a90322c4de213976
Publikováno v:
eLife, Vol 12 (2023)
Acid-sensing ion channels (ASICs) are trimeric proton-gated sodium channels. Recent work has shown that these channels play a role in necroptosis following prolonged acidic exposure like occurs in stroke. The C-terminus of ASIC1a is thought to mediat
Externí odkaz:
https://doaj.org/article/217688c146a2459fb987c3950f921eef
Autor:
Robert C. Klipp, John R. Bankston
Publikováno v:
Biophysical Journal. 122:394a-395a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::244c95c6d639a872076b913e66cb4615
https://doi.org/10.1016/j.bpj.2022.11.2155
https://doi.org/10.1016/j.bpj.2022.11.2155
Publikováno v:
Channels
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Acid-sensing ion channels (ASICs) are a family of proton-gated cation channels that contribute to a diverse array of functions including pain sensation, cell death during ischemia, and more broadly to neurotransmission in the central nervous system.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c723441c0da90716aaceab7b399ecbe
https://doi.org/10.1080/19336950.2021.1976946
https://doi.org/10.1080/19336950.2021.1976946
The mitochondrial calcium uniporter imports cytoplasmic Ca2+ into the mitochondrial matrix to regulate cell bioenergetics, Ca2+ signaling, and apoptosis. The uniporter contains the pore-forming MCU subunit, an EMRE protein that binds to MCU, and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a938f8f4cbe35c18b9412334cba1530
https://doi.org/10.1101/2021.11.15.468501
https://doi.org/10.1101/2021.11.15.468501
Autor:
Mallory E. Myers, Colin H. Peters, Lori A. Walker, Hicham Bichraoui, Charlie Haimbaugh, John R. Bankston, Catherine Proenza, Julie Juchno, Yanmei Du
Publikováno v:
Proc Natl Acad Sci U S A
Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteins modulate the biophysical properties of the pore-forming subunits. Hyperpolarization-activated, cyclic nucleotide-sensitive HCN4 channels are critical det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb4c81ab34f4d7ed79320eb3b5c1f9ef
https://pubmed.ncbi.nlm.nih.gov/32647060
https://pubmed.ncbi.nlm.nih.gov/32647060
Publikováno v:
Biophysical Journal. 118:10a-11a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fbfb1e77995c042dd86b8e59e9351fe1
https://doi.org/10.1016/j.bpj.2019.11.241
https://doi.org/10.1016/j.bpj.2019.11.241
Publikováno v:
The Journal of General Physiology
The integral membrane protein stomatin inhibits the gating of acid-sensing ion channels by an unknown mechanism. Klipp et al. suggest that stomatin binds to the C-terminus of ASIC3 and stabilizes the desensitized state via an interaction with the cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768edb042c1171097d8b32608dbbcbb8