Výsledky vyhledávání - "John R. Arthur"

Relative Abundance of Selenoprotein P Isoforms in Human Plasma Depends on Genotype, Se Intake, and Cancer Status

Autor: Catherine Méplan, John C. Mathers, Lynne K. Crosley, John E. Hesketh, John R. Arthur, Brian Burtle, Fergus Nicol

Publikováno v: Antioxidants & Redox Signaling. 11:2631-2640

Selenium (Se), a dietary trace metal essential for human health, is incorporated into selenoproteins as selenocysteine. Selenoprotein P (SePP), the major plasma selenoprotein, has both transport and antioxidant functions. In humans, it exists in plas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a24af91ea069ca2e67967da0d9c109d
https://doi.org/10.1089/ars.2009.2533

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Differential Effects of Doses and Forms of Dietary Selenium on Immune Cell Numbers in the Skin of Ultraviolet-irradiated and Unirradiated Mice

Autor: John R. Arthur, Steven G. McLean, Roderick C. McKenzie, Fergus Nicol, G J Beckett, Joanna C. Macve, Mary Norval, A. Forbes Howie

Publikováno v: Biological Trace Element Research. 125:255-267

The effect of three different doses of dietary L-selenomethionine (SM) and sodium selenite (SS) on skin selenium (Se) content, glutathione peroxidase (GPx) activity, Langerhans cell (LC) and mast cell numbers in ultraviolet radiation-B (UVB)-irradiat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f8f92f474c203ca5edf7c86dd9e107
https://doi.org/10.1007/s12011-008-8171-2

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Functional effects of a common single-nucleotide polymorphism (GPX4c718t) in the glutathione peroxidase 4 gene: interaction with sex

Autor: Catherine Méplan, John C. Mathers, Fergus Nicol, Graham W. Horgan, Lynne K. Crosley, John E. Hesketh, John R. Arthur

Publikováno v: The American Journal of Clinical Nutrition. 87:1019-1027

Background Selenium is essential for health in humans. Selenium is present as selenocysteine in selenoproteins such as the glutathione peroxidases (GPx). Selenocysteine incorporation requires specific structures in the 3'untranslated region (3'UTR) o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a55a3452b70fe386f185d9330a2858
https://doi.org/10.1093/ajcn/87.4.1019

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Evidence that a polymorphism within the 3′UTR of glutathione peroxidase 4 is functional and is associated with susceptibility to colorectal cancer

Autor: John C. Mathers, John Broom, N. Holloway, John E. Hesketh, Vasileios Pagmantidis, John R. Arthur, S. Kadri, Ann K. Daly, Giovanna Bermano, Robert Shiel, N. A. G. Mowat

Publikováno v: Genes & Nutrition. 2:225-232

Low selenium (Se) status has been associated with increased risk of colorectal cancer (CRC). Se is present as the amino acid selenocysteine in selenoproteins, such as the glutathione peroxidases. Se incorporation requires specific RNA structures in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44880d665666549b1c717be2c2fa2af0
https://doi.org/10.1007/s12263-007-0052-3

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Insulin, leptin, and adiponectin receptors in colon: regulation relative to differing body adiposity independent of diet and in response to dimethylhydrazine

Autor: Garry G. Duthie, Janice E. Drew, Andrew J. Farquharson, John R. Arthur, Julian G. Mercer, Lawrence N. Barrera, Sara Padidar, Philip C. Morrice

Publikováno v: American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G682-G691

Obesity has recently become a focus of research to elucidate diet and lifestyle factors as important risk factors for colon cancer. Altered levels of insulin, leptin, and adiponectin have been identified as potential candidates increasing colon cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c67925aee2053395c0d6ef167871502
https://doi.org/10.1152/ajpgi.00231.2007

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Extra Virgin Olive Oils Increase Hepatic Fat Accumulation and Hepatic Antioxidant Protein Levels in APOE-/- Mice

Autor: John R. Arthur, Gary Duncan, Carmen Arnal, Garry J. Rucklidge, Karen Ross, Jesús Osada, Jose M. Arbones-Mainar, Graham W. Horgan, Baukje de Roos, María A. Navarro, Martin D. Reid, Ricardo Carnicer

Publikováno v: Journal of Proteome Research. 6:4041-4054

We assessed the effects of Picual and Arbequina olive oil, rich and poor in polyphenols, respectively, on plasma lipid and glucose metabolism, hepatic fat content, and the hepatic proteome in female Apoe-/- mice. Both olive oils increased hepatic fat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01ce0d171d66a977c3db5fb8bee5755b
https://doi.org/10.1021/pr070321a

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Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender‐specific manner (the SELGEN study)

Autor: Catherine Méplan, Graham W. Horgan, Fergus Nicol, John C. Mathers, Geoffrey J. Beckett, Alexander F. Howie, Kristina E. Hill, Lynne K. Crosley, John E. Hesketh, John R. Arthur

Publikováno v: The FASEB Journal. 21:3063-3074

Selenium (Se), a micronutrient essential for human health, is incorporated into at least 25 selenoproteins including selenoprotein P (SePP), which transports Se within the body. This research identified two single nucleotide polymorphisms (SNPs) in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6584dd1942425b0f01493047f6bdb82
https://doi.org/10.1096/fj.07-8166com

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Differential regulation of expression of cytosolic and mitochondrial thioredoxin reductase in rat liver and kidney

Autor: Anna-Klara Rundlöf, Fergus Nicol, Elias S.J. Arnér, Lynne K. Crosley, John E. Hesketh, John R. Arthur, Catherine Méplan

Publikováno v: Archives of Biochemistry and Biophysics. 459:178-188

Adequate supply of selenium (Se) is critical for synthesis of selenoproteins through selenocysteine insertion mechanism. To explore this process we investigated the expression of the cytosolic and mitochondrial isoenzymes of thioredoxin reductase (Tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d3fca704a8065151dfc3751be4f5a4
https://doi.org/10.1016/j.abb.2006.12.029

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