Výsledky vyhledávání - "John R. Dedman"

Calcium-calmodulin-dependent protein kinase mediates the intracellular signalling pathways of cardiac apoptosis in mice with impaired glucose tolerance

Autor: Enrique Leo Portiansky, Francisco J. Alvarado, Marcia A. Kaetzel, John R. Dedman, Julieta Palomeque, Carolina Natalia Zanuzzi, Alicia Mattiazzi, Marilén Federico, Xander H.T. Wehrens, Leandro Matías Sommese, P.G. Blanco

Publikováno v: The Journal of Physiology. 595:4089-4108

Background The impact of cardiac apoptosis in pre-diabetic stages of diabetic cardiomyopathy is unknown. We described that myocytes from fructose-rich diet (FRD) animals exhibit arrhythmias produced by exacerbated Ca2+/calmodulin-protein kinase (CaMK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f506195dc766a48337e35fe66bbf3b2
https://doi.org/10.1113/jp273714

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Ryanodine receptor phosphorylation by CaMKII promotes spontaneous Ca2+ release events in a rodent model of early stage diabetes: The arrhythmogenic substrate

Autor: Marcia A. Kaetzel, María Cecilia Castro, John R. Dedman, Mark E. Anderson, Omar Velez Rueda, Leandro Matías Sommese, Carlos Alfredo Valverde, P.G. Blanco, Alicia Mattiazzi, Julieta Palomeque

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Background: Heart failure and arrhythmias occur more frequently in patients with type 2 diabetes (T2DM) than in the general population. T2DM is preceded by a prediabetic condition marked by elevated reactive oxygen species (ROS) and subclinical cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90c97e768d4e332bf24fa509881cd1f7
https://doi.org/10.1016/j.ijcard.2015.09.022

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SR-targeted CaMKII inhibition improves SR Ca2+ handling, but accelerates cardiac remodeling in mice overexpressing CaMKIIδC

Autor: Sabine Huke, Joan Heller Brown, Marcia A. Kaetzel, John R. Dedman, Donald M. Bers, Shikha Mishra, Jaime DeSantiago

Publikováno v: Journal of Molecular and Cellular Cardiology. 50:230-238

Cardiac myocyte overexpression of CaMKIIδ(C) leads to cardiac hypertrophy and heart failure (HF) possibly caused by altered myocyte Ca(2+) handling. A central defect might be the marked CaMKII-induced increase in diastolic sarcoplasmic reticulum (SR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e54553093499ed8861d4f4fdd6af8445
https://doi.org/10.1016/j.yjmcc.2010.10.014

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Studies on localization and function of annexin A4a within urinary bladder epithelium using a mouse knockout model

Autor: Mark L. Zeidel, Maximilian von Bodungen, Marcia A. Kaetzel, Warren G. Hill, Gerard Apodaca, Susan Meyers, John R. Dedman

Publikováno v: American Journal of Physiology-Renal Physiology. 294:F919-F927

Annexin A4 (anxA4) is a member of the Ca2+-dependent membrane-binding family of proteins implicated in the regulation of ion conductances, Ca2+homeostasis, and membrane trafficking. We demonstrate, in mice, that annexins 1–6 are present in whole bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c68f01e6294907f515748b9ae12d5fd
https://doi.org/10.1152/ajprenal.00265.2007

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Annexin A4 is a novel direct regulator of adenylyl cyclase type 5

Autor: Wilhelm Schmitz, Matthias D. Seidl, Uwe Kirchhefer, Volker Gerke, Marcia A. Kaetzel, Alexander Heinick, Frank Ulrich Müller, Frank Nunes, John R. Dedman, Christina Rolfes, Jan S. Schulte, Xenia Husser, Kirsten Himmler

Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 29(9)

Annexin A4 (AnxA4), a Ca(2+)- and phospholipid-binding protein, is up-regulated in the human failing heart. In this study, we examined the impact of AnxA4 on β-adrenoceptor (β-AR)/cAMP-dependent signal transduction. Expression of murine AnxA4 in hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a923271128107edc218fc1e94c7217
https://pubmed.ncbi.nlm.nih.gov/26023182

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Nuclear Ca2+/calmodulin-dependent protein kinase II in the murine heart

Autor: John R. Dedman, Marcia A. Kaetzel, Bailing Li

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1763(11):1275-1281

Ca(2+) signaling through CaMKII is critical in regulating myocyte function with regard to excitation-contraction-relaxation cycles and excitation-transcription coupling. To investigate the role of nuclear CaMKII in cardiac function, transgenic mice w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5509011eb56b7751370327684e55a3b4

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Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

Autor: Donald M. Bers, Timothy A. McKinsey, Eric N. Olson, Joan Heller Brown, Xu Wu, Ju Chen, Julie Bossuyt, Xiaodong Li, John R. Dedman, Tong Zhang

Publikováno v: Journal of Clinical Investigation. 116:675-682

Previous work showed that calmodulin (CaM) and Ca2+-CaM-dependent protein kinase II (CaMKII) are somehow involved in cardiac hypertrophic signaling, that inositol 1,4,5-trisphosphate receptors (InsP3Rs) in ventricular myocytes are mainly in the nucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fdbaac152bf6586f5c61ab896178e1a
https://doi.org/10.1172/jci27374

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Targeted inhibition of sarcoplasmic reticulum CaMKII activity results in alterations of Ca2+homeostasis and cardiac contractility

Autor: Bailing Li, Donald M. Bers, Eckard Picht, Wen Zhao, Yong Ji, Evangelia G. Kranias, Jaime DeSantiago, Jo El J. Schultz, Marcia A. Kaetzel, John R. Dedman

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 290:H599-H606

Transgenic (TG) mice expressing a Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitory peptide targeted to the cardiac myocyte longitudinal sarcoplasmic reticulum (LSR) display reduced phospholamban phosphorylation at Thr17and develop dila

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b3f3e72f6545177761312490dfa8ba
https://doi.org/10.1152/ajpheart.00214.2005

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Annexin VI regulation of cardiac function

Autor: John R. Dedman, Marcia A. Kaetzel

Publikováno v: Biochemical and Biophysical Research Communications. 322:1171-1177

Annexins are a family of membrane binding proteins that are characterized by a hypervariable amino terminus followed by a series of highly conserved Ca2+-phospholipid binding domains. Annexins function by binding to anionic phospholipid surfaces in a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df9fcfa0a87801adeebcfd47f7fbd4b8
https://doi.org/10.1016/j.bbrc.2004.07.127

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CyclinB1 expression is elevated and mitosis is delayed in HeLa cells expressing autonomous CaMKII

Autor: Shirelyn R. Beauman, John R. Dedman, Marcia A. Kaetzel, Begoña Campos

Publikováno v: Cellular Signalling. 15:1049-1057

Calcium is a second messenger that is implicated in the regulation of cell cycle transitions. Calmodulin is a ubiquitous protein that translates intracellular calcium signals and activates several enzymes including calcium/calmodulin-dependent protei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c51d76c482666e0c2de0c95cc1823280
https://doi.org/10.1016/s0898-6568(03)00068-8

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