Zobrazeno 1 - 10
of 1 368
pro vyhledávání: '"John R Yates"'
Autor:
Thu-Thuy Nguyen, Tae Heung Kim, Emily Bencosme-Cuevas, Jacquie Berry, Alex Samuel Kiarie Gaithuma, Moiz Ashraf Ansari, Tae Kwon Kim, Lucas Tirloni, Zeljko Radulovic, James J Moresco, John R Yates, Albert Mulenga
Publikováno v:
PLoS Pathogens, Vol 20, Iss 2, p e1012032 (2024)
Lyme disease (LD) caused by Borrelia burgdorferi is among the most important human vector borne diseases for which there is no effective prevention method. Identification of tick saliva transmission factors of the LD agent is needed before the highly
Externí odkaz:
https://doaj.org/article/6061833a4c23447c8ecc79d6e1361558
Autor:
Erik A Koppes, Marie A Johnson, James J Moresco, Patrizia Luppi, Dale W Lewis, Donna B Stolz, Jolene K Diedrich, John R Yates, Ronald C Wek, Simon C Watkins, Susanne M Gollin, Hyun Jung Park, Peter Drain, Robert D Nicholls
Publikováno v:
PLoS Genetics, Vol 19, Iss 4, p e1010710 (2023)
Prader-Willi syndrome (PWS) is a multisystem disorder with neurobehavioral, metabolic, and hormonal phenotypes, caused by loss of expression of a paternally-expressed imprinted gene cluster. Prior evidence from a PWS mouse model identified abnormal p
Externí odkaz:
https://doaj.org/article/511e07a3ded143c49933e62d23762e4c
Autor:
Yang S Chen, Wanfu Hou, Sharon Tracy, Alex T Harvey, Vince Harjono, Fan Xu, James J Moresco, John R Yates III, Brian M Zid
Publikováno v:
eLife, Vol 11 (2022)
During times of unpredictable stress, organisms must adapt their gene expression to maximize survival. Along with changes in transcription, one conserved means of gene regulation during conditions that quickly repress translation is the formation of
Externí odkaz:
https://doaj.org/article/9a40172625d64ca686f4f4c4e251ccc3
Autor:
Zehra Yildirim, Sabyasachi Baboo, Syed M Hamid, Asli E Dogan, Ozlem Tufanli, Sabrina Robichaud, Christina Emerton, Jolene K Diedrich, Hasan Vatandaslar, Fotis Nikolos, Yanghong Gu, Takao Iwawaki, Elizabeth Tarling, Mireille Ouimet, David L Nelson, John R Yates III, Peter Walter, Ebru Erbay
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 4, Pp n/a-n/a (2022)
Abstract Fragile X Mental Retardation protein (FMRP), widely known for its role in hereditary intellectual disability, is an RNA‐binding protein (RBP) that controls translation of select mRNAs. We discovered that endoplasmic reticulum (ER) stress i
Externí odkaz:
https://doaj.org/article/b76dfacbb1c646c7852f08635a49b842
Autor:
Sahil H Shah, Lucio M Schiapparelli, Yuanhui Ma, Satoshi Yokota, Melissa Atkins, Xin Xia, Evan G Cameron, Thanh Huang, Sarah Saturday, Catalina B Sun, Cara Knasel, Seth Blackshaw, John R Yates, Hollis T Cline, Jeffrey L Goldberg
Publikováno v:
eLife, Vol 11 (2022)
Many neurons in the adult central nervous system, including retinal ganglion cells (RGCs), degenerate and die after injury. Early axon protein and organelle trafficking failure is a key component in many neurodegenerative disorders yet changes to axo
Externí odkaz:
https://doaj.org/article/fff78c4323f14743add545a16bd5e20e
Autor:
Charlotte P Choi, Rebecca J Tay, Margaret R Starostik, Suhua Feng, James J Moresco, Brooke E Montgomery, Emily Xu, Maya A Hammonds, Michael C Schatz, Taiowa A Montgomery, John R Yates III, Steven E Jacobsen, John K Kim
Publikováno v:
eLife, Vol 10 (2021)
Piwi-interacting RNAs (piRNAs) play essential roles in silencing repetitive elements to promote fertility in metazoans. Studies in worms, flies, and mammals reveal that piRNAs are expressed in a sex-specific manner. However, the mechanisms underlying
Externí odkaz:
https://doaj.org/article/034abfc8c9fd447491aed156f688b327
Autor:
Gregory G Fuller, Ting Han, Mallory A Freeberg, James J Moresco, Amirhossein Ghanbari Niaki, Nathan P Roach, John R Yates III, Sua Myong, John K Kim
Publikováno v:
eLife, Vol 9 (2020)
In hypoxic stress conditions, glycolysis enzymes assemble into singular cytoplasmic granules called glycolytic (G) bodies. G body formation in yeast correlates with increased glucose consumption and cell survival. However, the physical properties and
Externí odkaz:
https://doaj.org/article/0f9b719ba4744b1193c3524f0a1df3e0
Autor:
Tae Kwon Kim, Lucas Tirloni, Antônio F M Pinto, Jolene K Diedrich, James J Moresco, John R Yates, Itabajara da Silva Vaz, Albert Mulenga
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 2, p e0007758 (2020)
Amblyomma americanum ticks transmit more than a third of human tick-borne disease (TBD) agents in the United States. Tick saliva proteins are critical to success of ticks as vectors of TBD agents, and thus might serve as targets in tick antigen-based
Externí odkaz:
https://doaj.org/article/3d9ec60d6d424de1b5b2e2fa27c27b36
Autor:
Masaharu Iwasaki, Petra Minder, Yíngyún Caì, Jens H Kuhn, John R Yates, Bruce E Torbett, Juan C de la Torre
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008289 (2020)
[This corrects the article DOI: 10.1371/journal.ppat.1006892.].
Externí odkaz:
https://doaj.org/article/6a47d767955344aeaaa961a615513825
Autor:
Jean J Kim, Jeffrey N Savas, Meghan T Miller, Xindao Hu, Cassiano Carromeu, Mathieu Lavallée-Adam, Beatriz C G Freitas, Alysson R Muotri, John R Yates, Anirvan Ghosh
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0212553 (2019)
Rett syndrome (RTT) is a pervasive developmental disorder caused by mutations in MECP2. Complete loss of MECP2 function in males causes congenital encephalopathy, neurodevelopmental arrest, and early lethality. Induced pluripotent stem cell (iPSC) li
Externí odkaz:
https://doaj.org/article/87e01bbb9e4e45acaf98802445390387