Zobrazeno 1 - 10
of 114
pro vyhledávání: '"John R Webb"'
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210902 (2019)
Extracellular bacteria that spread via the vasculature employ invasive mechanisms that mirror those of metastatic tumor cells, including intravasation into the bloodstream and survival during hematogenous dissemination, arrestation despite blood flow
Externí odkaz:
https://doaj.org/article/4d4ce48b0c6e4b72b4d0c934dca714a3
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32805 (2012)
Nitrotyrosination of proteins, a hallmark of inflammation, may result in the production of MHC-restricted neoantigens that can be recognized by T cells and bypass the constraints of immunological self-tolerance. Here we biochemically and structurally
Externí odkaz:
https://doaj.org/article/ccf516b7339047739f115bb61f14d9c5
Autor:
Eric Tran, Julie S Nielsen, Darin A Wick, Alvin V Ng, Lisa D S Johnson, Nancy J Nesslinger, Elissa McMurtrie, John R Webb, Brad H Nelson
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e15625 (2010)
BACKGROUND: Host T-cell responses are associated with favorable outcomes in epithelial ovarian cancer (EOC), but it remains unclear how best to promote these responses in patients. Toward this goal, we evaluated a panel of clinically relevant cytokin
Externí odkaz:
https://doaj.org/article/659edce7fc634915b313476bead11d53
Autor:
Katy Milne, Rebecca O Barnes, Adam Girardin, Melanie A Mawer, Nancy J Nesslinger, Alvin Ng, Julie S Nielsen, Robert Sahota, Eric Tran, John R Webb, May Q Wong, Darin A Wick, Andrew Wray, Elissa McMurtrie, Martin Köbel, Steven E Kalloger, C Blake Gilks, Peter H Watson, Brad H Nelson
Publikováno v:
PLoS ONE, Vol 3, Iss 10, p e3409 (2008)
BACKGROUND: Tumor-infiltrating CD8+ T cells are correlated with prolonged progression-free and overall survival in epithelial ovarian cancer (EOC). A significant fraction of EOC patients mount autoantibody responses to various tumor antigens, however
Externí odkaz:
https://doaj.org/article/6c67b359c83942d89e090359c67e6364
Autor:
Brad H. Nelson, Christian Steidl, John R. Webb, Katy Milne, Shelby Thornton, Lauren C. Chong, Elizabeth A. Chavez, Nicole S. Gierc, Julian Smazynski, Maartje C.A. Wouters, Céline M. Laumont
Supplementary Figure S14 shows the extent of TCR overlap between T-cell subsets isolated from primary HGSC tumor samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34cf426db4e212ba09e3a6803100ce42
https://doi.org/10.1158/1078-0432.22480818.v1
https://doi.org/10.1158/1078-0432.22480818.v1
Purpose: CD103 is expressed in several immune cell types but in the context of the intratumoral immune response may be most important as a marker of antigen-activated CD8 T cells.Methods: We have examined the prognostic significance of CD103 TILs in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7111b091fe44bc00a88ce5a32aaa57da
https://doi.org/10.1158/1078-0432.c.6526716
https://doi.org/10.1158/1078-0432.c.6526716
Supplemental Table 1. A report concerning the source of the biospecimen and data using the BRISQ guidelines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1048b02fe838e415c524a3720f29ae8
https://doi.org/10.1158/1078-0432.22467699
https://doi.org/10.1158/1078-0432.22467699
Autor:
Brad H. Nelson, Rob A. Holt, Peter H. Watson, Kwame Twumasi-Boateng, Mauro Castellarin, Katy Milne, David R. Kroeger, Spencer D. Martin, Julie S. Nielsen, John R. Webb, Darin A. Wick
Purpose: Cancers accumulate mutations over time, each of which brings the potential for recognition by the immune system. We evaluated T-cell recognition of the tumor mutanome in patients with ovarian cancer undergoing standard treatment.Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ad806360bdb11a8d0aa7fb33957838
https://doi.org/10.1158/1078-0432.c.6521546
https://doi.org/10.1158/1078-0432.c.6521546
Autor:
Brad H. Nelson, Christian Steidl, John R. Webb, Katy Milne, Shelby Thornton, Lauren C. Chong, Elizabeth A. Chavez, Nicole S. Gierc, Julian Smazynski, Maartje C.A. Wouters, Céline M. Laumont
Supplementary Table S4 presents the list of differentially expressed genes identified between triple-positive and triple-negative Tregs and between triple-positive and other Tregs.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::201408ad5046aeece798096513de96c1
https://doi.org/10.1158/1078-0432.22480770.v1
https://doi.org/10.1158/1078-0432.22480770.v1
Supplemental Figure 2: Prognostic impact of CD103 and CD8 alone and combination in the Basel-like subset of breast cancers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e123fe30899a07f8d3cbb8c18ddbb591
https://doi.org/10.1158/1078-0432.22467702.v1
https://doi.org/10.1158/1078-0432.22467702.v1