Zobrazeno 1 - 10
of 126
pro vyhledávání: '"John R Ussher"'
Autor:
Yana Kibalnyk, Elia Afanasiev, Ronan M. N. Noble, Adrianne E. S. Watson, Irina Poverennaya, Nicole L. Dittmann, Maria Alexiou, Kara Goodkey, Amanda A. Greenwell, John R. Ussher, Igor Adameyko, James Massey, Daniel Graf, Stephane L. Bourque, Jo Anne Stratton, Anastassia Voronova
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract ANKRD11 (Ankyrin Repeat Domain 11) is a chromatin regulator and a causative gene for KBG syndrome, a rare developmental disorder characterized by multiple organ abnormalities, including cardiac defects. However, the role of ANKRD11 in heart
Externí odkaz:
https://doaj.org/article/ce8c90516c504572ba5ad45d0a89daf1
Autor:
Jordan S.F. Chan, Seyed Amirhossein Tabatabaei Dakhili, Maria Areli Lorenzana-Carrillo, Keshav Gopal, Serena M. Pulente, Amanda A. Greenwell, Kunyan Yang, Christina T. Saed, Magnus J. Stenlund, Sally R. Ferrari, Indiresh A. Mangra-Bala, Tanin Shafaati, Rakesh K. Bhat, Farah Eaton, Michael Overduin, Sebastian Beck Jørgensen, Gregory R. Steinberg, Erin E. Mulvihill, Gopinath Sutendra, John R. Ussher
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114573- (2024)
Summary: Growth differentiation factor 15 (GDF15) is a peptide with utility in obesity, as it decreases appetite and promotes weight loss. Because obesity increases the risk for type 2 diabetes (T2D) and cardiovascular disease, it is imperative to un
Externí odkaz:
https://doaj.org/article/8e982b3f2425453094ab8152492fec0a
Autor:
John R Ussher, Clifford D L Folmes, Wendy Keung, Natasha Fillmore, Jagdip S Jaswal, Virgilio J Cadete, Donna L Beker, Victoria H Lam, Liyan Zhang, Gary D Lopaschuk
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e37703 (2012)
OBJECTIVE: Diet-induced obesity (DIO) leads to an accumulation of intra-myocardial lipid metabolites implicated in causing cardiac insulin resistance and contractile dysfunction. One such metabolite is ceramide, and our aim was to determine the effec
Externí odkaz:
https://doaj.org/article/eb5a06fe1d3c43e38320d5c0fab98aec
Autor:
Amanda A. Greenwell, Seyed Amirhossein Tabatabaei Dakhili, Cory S. Wagg, Christina T. Saed, Jordan S.F. Chan, Kunyan Yang, Indiresh A. Mangra‐Bala, Magnus J. Stenlund, Farah Eaton, Keshav Gopal, Jason R.B. Dyck, Gary D. Lopaschuk, John R. Ussher
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 7 (2024)
Externí odkaz:
https://doaj.org/article/b3e4aaaa3d6c48c5ba50d1495bac3ac6
Autor:
Keshav Gopal, Qutuba G. Karwi, Seyed Amirhossein Tabatabaei Dakhili, Cory S. Wagg, Liyan Zhang, Qiuyu Sun, Christina T. Saed, Sai Panidarapu, Riccardo Perfetti, Ravichandran Ramasamy, John R. Ussher, Gary D. Lopaschuk
Publikováno v:
Cardiovascular Diabetology, Vol 22, Iss 1, Pp 1-12 (2023)
Abstract Background Cardiovascular diseases, including diabetic cardiomyopathy, are major causes of death in people with type 2 diabetes. Aldose reductase activity is enhanced in hyperglycemic conditions, leading to altered cardiac energy metabolism
Externí odkaz:
https://doaj.org/article/51239f61fe9f4aaa82e566b6c24008f4
Publikováno v:
Nutrients, Vol 15, Iss 19, p 4228 (2023)
In recent years, ketogenic diets and ketone supplements have increased in popularity, particularly as a mechanism to improve exercise performance by modifying energetics. Since the skeletal muscle is a major metabolic and locomotory organ, it is impo
Externí odkaz:
https://doaj.org/article/2059796fe030409e9759266621d40cbf
Autor:
Amanda A. Greenwell, Seyed Amirhossein Tabatabaei Dakhili, Keshav Gopal, Christina T. Saed, Jordan S. F. Chan, Nick Kazungu Mugabo, Pavel Zhabyeyev, Farah Eaton, Jennifer Kruger, Gavin Y. Oudit, John R. Ussher
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Barth syndrome (BTHS) is a rare genetic disorder due to mutations in the TAFAZZIN gene, leading to impaired maturation of cardiolipin and thereby adversely affecting mitochondrial function and energy metabolism, often resulting in cardiomyopathy. In
Externí odkaz:
https://doaj.org/article/5408c8de8162435f8fa4dc2704c62e07
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Barth Syndrome (BTHS) is a rare X-linked mitochondrial disorder due to mutations in the gene TAFAZZIN, which leads to immature cardiolipin (CL) remodeling and is characterized by the development of cardiomyopathy. The immature CL remodeling in BTHS r
Externí odkaz:
https://doaj.org/article/990200778eb24a91a0a6b34f452f2aff
New Therapeutic Options for Type 2 Diabetes Mellitus and Their Impact Against Ischemic Heart Disease
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Type 2 diabetes mellitus (T2DM) greatly increases risk for cardiovascular disease, including ischemic heart disease and myocardial infarction. With the completion of several cardiovascular outcomes trials (CVOTs) for new glucose-lowering therapies, i
Externí odkaz:
https://doaj.org/article/5e9a49e2eb9a4116bcbdda49676f9a8b
Autor:
Yongneng Zhang, Sotirios D. Zervopoulos, Aristeidis E. Boukouris, Maria Areli Lorenzana‐Carrillo, Bruno Saleme, Linda Webster, Yongsheng Liu, Alois Haromy, Seyed Amirhossein Tabatabaei Dakhili, John R. Ussher, Gopinath Sutendra, Evangelos D. Michelakis
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 23 (2021)
Background Isolated loss‐of‐function single nucleotide polymorphisms (SNPs) for SIRT3 (a mitochondrial deacetylase) and UCP2 (an atypical uncoupling protein enabling mitochondrial calcium entry) have been associated with both pulmonary arterial h
Externí odkaz:
https://doaj.org/article/a49e84a6a5684a6698b83b6a9fe8c44a