Zobrazeno 1 - 10 of 36 pro vyhledávání: '"John R Pfeiffer"'
1
Akademický článek
Novel computational biology modeling system can accurately forecast response to neoadjuvant therapy in early breast cancer
Autor: Joseph R. Peterson, John A. Cole, John R. Pfeiffer, Gregory H. Norris, Yuhan Zhang, Dorys Lopez-Ramos, Tushar Pandey, Matthew Biancalana, Hope R. Esslinger, Anuja K. Antony, Vinita Takiar
Publikováno v: Breast Cancer Research, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background Generalizable population-based studies are unable to account for individual tumor heterogeneity that contributes to variability in a patient’s response to physician-chosen therapy. Although molecular characterization of tumors h
Externí odkaz: https://doaj.org/article/12eef036e02a49309bc1c05dd6fdb0b4
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2
Akademický článek
Next generation immuno-oncology tumor profiling using a rapid, non-invasive, computational biophysics biomarker in early-stage breast cancer
Autor: Daniel Cook, Matthew Biancalana, Nicole Liadis, Dorys Lopez Ramos, Yuhan Zhang, Snehal Patel, Joseph R. Peterson, John R. Pfeiffer, John A. Cole, Anuja K. Antony
Publikováno v: Frontiers in Artificial Intelligence, Vol 6 (2023)
BackgroundImmuno-oncology (IO) therapies targeting the PD-1/PD-L1 axis, such as immune checkpoint inhibitor (ICI) antibodies, have emerged as promising treatments for early-stage breast cancer (ESBC). Despite immunotherapy's clinical significance, th
Externí odkaz: https://doaj.org/article/be8738fdce2d43f1bb22f5d1661eba9f
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3
Akademický článek
Blood-derived deoxyribonucleic acid methylation clusters associate with adverse social exposures and endophenotypes of stress-related psychiatric illness in a trauma-exposed cohort of women
Autor: John R. Pfeiffer, Sanne J. H. van Rooij, Yara Mekawi, Negar Fani, Tanja Jovanovic, Vasiliki Michopoulos, Alicia K. Smith, Jennifer S. Stevens, Monica Uddin
Publikováno v: Frontiers in Psychiatry, Vol 13 (2022)
Adverse social exposures (ASEs) such as low income, low educational attainment, and childhood/adult trauma exposure are associated with variability in brain region measurements of gray matter volume (GMV), surface area (SA), and cortical thickness (C
Externí odkaz: https://doaj.org/article/77287209e3de413eba775923a027fb3d
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4
Abstract P1-08-21: Assessing the impact of treatment interruptions during neoadjuvant therapy in early stage breast cancer
Autor: Tushar Pandey, John R Pfeiffer, Eduardo Braun, Hiroyuki Abe, Frederick Howard, Gong He, Alexander T Pearson, Rita Nanda
Publikováno v: Cancer Research. 82:P1-08
Introduction Chemotherapy for early stage breast cancer is associated with a plethora of side effects including fatigue, alopecia, neuropathy, cardiotoxicity, myelosuppression, gastrointestinal symptoms, fertility issues, memory impairment, and mouth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b88cfab48cffcce5d7c21172b2590b02
https://doi.org/10.1158/1538-7445.sabcs21-p1-08-21
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5
Abstract P1-08-31: Simbiosys tumorscope: Biophysical modeling of patient-specific response to chemotherapy
Autor: John A Cole, Joseph R Peterson, Tyler M Earnest, Michael J Hallock, Daniel J Cook, Eduardo Braun, Anu Antony, John R Pfeiffer, Tushar Pandey
Publikováno v: Cancer Research. 82:P1-08
Background: Breast Cancer (BC) patients exhibit a wide variety of responses to neoadjuvant chemotherapy (NACT). This is driven by factors both intrinsic (e.g., mutations, dysregulation, metabolic reprogramming) and extrinsic (e.g., nutrient/drug perf
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94de88ce9533cba958245dcb573cc3f8
https://doi.org/10.1158/1538-7445.sabcs21-p1-08-31
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6
Epigenome-wide meta-analysis of PTSD symptom severity in three military cohorts implicates DNA methylation changes in genes involved in immune system and oxidative stress
Autor: Seyma Katrinli, Adam X. Maihofer, Agaz H. Wani, John R. Pfeiffer, Elizabeth Ketema, Andrew Ratanatharathorn, Dewleen G. Baker, Marco P. Boks, Elbert Geuze, Ronald C. Kessler, Victoria B. Risbrough, Bart P. F. Rutten, Murray B. Stein, Robert J. Ursano, Eric Vermetten, Mark W. Logue, Caroline M. Nievergelt, Alicia K. Smith, Monica Uddin
Publikováno v: Molecular Psychiatry, 27, 1720-1728. SPRINGERNATURE
Molecular Psychiatry, 27(3), 1720-1728. Nature Publishing Group
Molecular psychiatry, vol 27, iss 3
Epigenetic factors modify the effects of environmental factors on biological outcomes. Identification of epigenetic changes that associate with PTSD is therefore a crucial step in deciphering mechanisms of risk and resilience. In this study, our goal
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bd36c4710d5098a199646d7115429a9
https://hdl.handle.net/1887/3563666
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8
Abstract P4-05-03: Evaluation of the prognostic accuracy of SimBioSys TumorScope in early breast cancer
Autor: Frederick M. Howard, Gong He, John R Pfeiffer, Joseph R Peterson, John A. Cole, Alexander T. Pearson, Hiroyuki Abe, Rita Nanda
Publikováno v: Cancer Research. 82:P4-05
Background: Pathological complete response (pCR) is a well validated endpoint for early-stage breast cancer (EBC) patients treated with neoadjuvant chemotherapy (NAT), with a strong correlation with long term outcomes such as event free survival (EFS
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1da74d3e3253199146d68b38148ea600
https://doi.org/10.1158/1538-7445.sabcs21-p4-05-03
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9
Prediction of response to neoadjuvant therapy (NAT) in early breast cancer (EBC) at community hospitals: SimBioSys TumorScope Validation Study
Autor: John R. Pfeiffer, Karen Zwicky, Tushar Pandey, Anu K. Antony, The SimBioSys Team, John A. Cole, Clifford Wolf
Publikováno v: Journal of Clinical Oncology. 40:598-598
598 Background: While most cancer patients are treated at community hospitals, specialized equipment, diagnostic tests, and therapeutic regimens are generally validated at academic settings. Here we present a novel approach to precision medicine to i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3be0f9c6307ed5b48accf65426cce220
https://doi.org/10.1200/jco.2022.40.16_suppl.598
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10
The case for simul-omics: Identifying IO biomarkers of ganitumab-metformin pathological complete response (pCR)
Autor: John R. Pfeiffer, Yuhan Zhang, Anu K. Antony, The SimBioSys Team, John A. Cole
Publikováno v: Journal of Clinical Oncology. 40:e12551-e12551
e12551 Background: During the I-SPY2 clinical trial, ganitumab (G) immunotherapy (IO) was co-administered with metformin (GM) to counteract G-induced hyperglycemia. The GM + standard of care (SOC) combination showed promising results but did not meet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3664ef3fbe6e30035c2cb4dc2ca19ed8
https://doi.org/10.1200/jco.2022.40.16_suppl.e12551
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