Zobrazeno 1 - 10
of 39
pro vyhledávání: '"John R O'Kusky"'
Publikováno v:
ASN Neuro, Vol 4 (2012)
Signalling through the IGF1R [type 1 IGF (insulin-like growth factor) receptor] and canonical Wnt signalling are two signalling pathways that play critical roles in regulating neural cell generation and growth. To determine whether the signalling thr
Externí odkaz:
https://doaj.org/article/4035e6b8fda543ce9c8f4c092dffe9d0
Autor:
Katherine Dinelle, Matthew D. Walker, Matthew J. Farrer, Qing Miao, Anna Schildt, Vesna Sossi, John R. O'Kusky, Michael Schulzer, Doris J. Doudet
Publikováno v:
Journal of Parkinson's Disease, 9(1), 121-139. IOS Press
Background: Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic risk factor for Parkinson's disease (PD). While the corresponding pathogenic mechanisms remain largely unknown, LRRK2 has been implicated in the immune system.Obje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cbd1fa6d78eb80338a9f6c2b12ac74
https://doi.org/10.3233/jpd-181446
https://doi.org/10.3233/jpd-181446
Publikováno v:
Experimental Neurology. 227:180-187
d -3-Hydroxybutyrate (3OHB) is an alternative energy substrate for the brain during hypoglycemia, especially in infancy. Knowledge of the capacity and limits of 3OHB to compensate for cerebral glucose depletion during hypoglycemia in developing brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f9bee6ab31a30ffa43220994c2c607f
https://doi.org/10.1016/j.expneurol.2010.10.013
https://doi.org/10.1016/j.expneurol.2010.10.013
Autor:
Xiujuan Wu, John Walker, Bruce A. Vallance, Lee Boyer, John R. O'Kusky, Kirk Bergstrom, Alison M.J. Buchan, Kevan Jacobson, Karen Madsen
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 294:G295-G306
Saccharomyces boulardii has received increasing attention as a probiotic effective in the prevention and treatment of infectious and inflammatory bowel diseases. The aim of this study was to examine the ameliorating effects of S. boulardii on Citroba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51d504ed957292ad430cd7705b28937e
https://doi.org/10.1152/ajpgi.00173.2007
https://doi.org/10.1152/ajpgi.00173.2007
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 66:576-584
Intrastriatal transplantation of gelatin microcarrier-attached human retinal pigment epithelial cells (hRPE-GM) may represent an alternative source for cell therapy in Parkinson disease (PD). The use of human retinal pigment epithelial (hRPE) cells i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16809a4f322bfe6b95338addee7adaa5
https://doi.org/10.1097/nen.0b013e318093e521
https://doi.org/10.1097/nen.0b013e318093e521
Publikováno v:
The Journal of Nutrition. 136:1570-1575
Docosahexaenoic acid [22:6(n-3)] is enriched in brain membrane phospholipids and essential for brain function. Neurogenesis during embryonic and fetal development requires synthesis of large amounts of membrane phospholipid. We determined whether die
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48efebdf8730b0ecaf303a694969c1dd
https://doi.org/10.1093/jn/136.6.1570
https://doi.org/10.1093/jn/136.6.1570
Publikováno v:
Developmental Brain Research. 154:227-237
The in vivo actions of insulin-like growth factor-I (IGF-I) on the growth and development of the cerebral cortex were investigated in transgenic (Tg) mice that overexpress IGF-I in the brain, beginning as early as embryonic day (E) 13. Compared to no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df112586c52ccf60a0cdc6afcca33161
https://doi.org/10.1016/j.devbrainres.2004.10.016
https://doi.org/10.1016/j.devbrainres.2004.10.016
Publikováno v:
The Journal of Neuroscience. 20:8435-8442
Thein vivoactions of insulin-like growth factor-I (IGF-I) on the growth and development of the hippocampal dentate gyrus were investigated in transgenic mice that overexpress IGF-I postnatally in the brain and in normal nontransgenic littermate contr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daf60fdfaac3cc452918f56afc78338e
https://doi.org/10.1523/jneurosci.20-22-08435.2000
https://doi.org/10.1523/jneurosci.20-22-08435.2000
Publikováno v:
Brain Research. 818:468-479
Huntington's disease (HD) is a progressive neurodegenerative disorder associated with CAG repeat expansion within a novel gene (IT15). We have previously created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homologue of the HD gene. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89fd38a63ad0ae5a7ccef786e50b259f
https://doi.org/10.1016/s0006-8993(98)01312-2
https://doi.org/10.1016/s0006-8993(98)01312-2
Autor:
John R. O'Kusky
Publikováno v:
Developmental Brain Research. 108:179-191
Morphometric analyses were performed to investigate the progressive and regressive phases of synaptogenesis in the hypoglossal nucleus of the rat during normal postnatal development. The total volume of the hypoglossal nucleus and both the numerical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c195ddccba241b3be96808f968c405ed
https://doi.org/10.1016/s0165-3806(98)00048-0
https://doi.org/10.1016/s0165-3806(98)00048-0