Zobrazeno 1 - 10
of 67
pro vyhledávání: '"John R James"'
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 5, Pp n/a-n/a (2021)
Abstract T cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response, which is hypothesized to depend on T cells combining stimuli from multiple antigen‐presenting cell interactions into a mo
Externí odkaz:
https://doaj.org/article/f7da0b203ed64852a3265141d391e2e1
Autor:
Anetta Marcinek, Bettina Brauchle, Lisa Rohrbacher, Gerulf Hänel, Nora Philipp, Florian Märkl, Thaddäus Strzalkowski, Sonja M. Lacher, Dragica Udiljak, Karsten Spiekermann, Sebastian Theurich, Sebastian Kobold, Roman Kischel, John R. James, Veit L. Bücklein, Marion Subklewe
Publikováno v:
Cancer Immunology, Immunotherapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44e89147d3fb33bc7a716fe89d6309ea
https://doi.org/10.1007/s00262-023-03457-9
https://doi.org/10.1007/s00262-023-03457-9
Autor:
Anetta Marcinek, Bettina Brauchle, Lisa Rohrbacher, Gerulf Hänel, Nora Philipp, Florian Märkl, Thaddäus Strzalkowski, Sonja M. Lacher, Dragica Udiljak, Karsten Spiekermann, Sebastian Theurich, Sebastian Kobold, Roman Kischel, John R. James, Veit L. Bücklein, Marion Subklewe
Publikováno v:
Cancer Immunology, Immunotherapy.
Bispecific T-cell engager (BiTE®) molecules recruit T cells to cancer cells through CD3ε binding, independently of T-cell receptor (TCR) specificity. Whereas physiological T-cell activation is dependent on signal 1 (TCR engagement) and signal 2 (co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d261a13bce3e2164141a44c5580a8a48
https://doi.org/10.1007/s00262-023-03439-x
https://doi.org/10.1007/s00262-023-03439-x
Autor:
Raffaella Colombatti, Alecia C. Nero, Erfan Nur, Cassandra Trimnell, John R. James, Olivera Rajkovic-Hooley, Tom Bailey, Jean-Benoît Arlet, Mariane de Montalembert, Ifeyinwa Osunkwo, Caterina P. Minniti, Suman Jain, Miguel R. Abboud, Fuad El Rassi, Beverley Francis-Gibson, Wasil Jastaniah, Biree Andemariam, Nicholas Ramscar, Marimilia Pita, Baba Inusa
Publikováno v:
Blood. 136:8-10
Background: SWAY was a cross-sectional survey that assessed the global impact and treatment of sickle cell disease (SCD) (James et al. ASH 2019). SCD puts patients at risk of multiple complications driven by vaso-occlusion and hemolytic anemia. Vaso-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74b4c4b0a2213b89defe37bb12ccb0db
https://doi.org/10.1182/blood-2020-137103
https://doi.org/10.1182/blood-2020-137103
Autor:
Tom Bailey, Jean-Benoît Arlet, Beverley Francis-Gibson, Baba Inusa, Caterina P. Minniti, John R. James, Alecia C. Nero, Olivera Rajkovic-Hooley, Raffaella Colombatti, Biree Andemariam, Cassandra Trimnell, Fuad El Rassi, Erfan Nur, Miguel R. Abboud, Nicholas Ramscar, Mariane de Montalembert, Marimilia Pita, Wasil Jastaniah, Ifeyinwa Osunkwo, Suman Jain
Publikováno v:
Blood. 136:3-5
Background: Sickle cell disease (SCD) is associated with many clinical complications, with vaso-occlusive crises (VOCs) being a hallmark of the disease. SCD-related complications are largely driven by vaso-occlusion and hemolytic anemia, and can lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfd823ce6a2378e59a7753b21a693bd
https://doi.org/10.1182/blood-2020-136073
https://doi.org/10.1182/blood-2020-136073
Autor:
Sophie Hambleton, Perrine Pennamen, John R. James, Meghan Acres, Wolfram Haller, Anas M. Alazami, Yasuhiro Yamazaki, James Thaventhiran, Jan Sinclair, Yu Zhang, Rainer Doffinger, Helen F. Matthews, David MacDonald, Zinan Zhang, Sophie Naudion, Kenneth G. C. Smith, Fanny Pelluard, Huda Alajlan, Yorgo Modis, Karin R. Engelhardt, Carlos P. Mata, Claire Bowen, Florian Gothe, Caroline Rooryck, Luigi D. Notarangelo, Hamoud Al-Mousa, Michael J. Lenardo
Publikováno v:
The Journal of Experimental Medicine
Zhang et al. identify human IL-2Rβ deficiency as a cause of severe immune dysregulation. The hypomorphic gene mutations reveal variable IL-2Rβ expression and function between different lymphocyte subsets as a means of selectively modulating immune
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95ddd970c7d05489f1941e7126e17ac9
https://doi.org/10.1084/jem.20182304
https://doi.org/10.1084/jem.20182304
Autor:
Olivera Rajkovic-Hooley, Suman Jain, Mariane de Montalembert, Biree Andemariam, Ifeyinwa Osunkwo, Fuad El Rassi, Laurie DeBonnett, Nicholas Ramscar, Alecia C. Nero, Tom Bailey, Baba Inusa, Jean Benoit Arlet, Caterina P. Minniti, Miguel R. Abboud, John R. James, Raffaella Colombatti, Marimilia Pita, Wasil Jastaniah, Erfan Nur, Beverley Francis-Gibson, Cassandra Trimnell
Publikováno v:
American journal of hematology, 96(4), 404-417. Wiley-Liss Inc.
American Journal of Hematology
American Journal of Hematology
Sickle cell disease (SCD) is a genetic disorder, characterized by hemolytic anemia and vaso‐occlusive crises (VOCs). Data on the global SCD impact on quality of life (QoL) from the patient viewpoint are limited. The international Sickle Cell World
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66b76675bc2ae4e1ba064e55d1b77bcf
https://pubmed.ncbi.nlm.nih.gov/33393092
https://pubmed.ncbi.nlm.nih.gov/33393092
SUMMARYT cells discriminate between healthy and infected cells with remarkable sensitivity when mounting an immune response. It has been hypothesized that this efficient detection requires combining signals from discrete antigen-presenting cell inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::22b35b27d785481925757ad8a3c23f96
https://doi.org/10.1101/2020.10.30.362194
https://doi.org/10.1101/2020.10.30.362194
Autor:
Gillian Farnie, J.C. Ashworth, Catherine L.R. Merry, John R. James, Sara Pijuan-Galito, Amanda J. Wright, Kenton P. Arkill, Manlio Tassieri, A. Thompson, Kate Meade, Katarzyna Lis-Slimak, Jamie L. Thompson, C.E. Slater, Rebecca J. Holley
Publikováno v:
Matrix Biol
Current materials used for in vitro 3D cell culture are often limited by their poor similarity to human tissue, batch-to-batch variability and complexity of composition and manufacture. Here, we present a “blank slate” culture environment based o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7792706a7874e13111af64c5f4c90ee
https://eprints.gla.ac.uk/189044/1/189044.pdf
https://eprints.gla.ac.uk/189044/1/189044.pdf
Autor:
Jincy Paulose, Tom Bailey, Biree Andemariam, Caterina P. Minniti, Fuad El Rassi, Ifeyinwa Osunkwo, John R. James, Beverley Francis-Gibson, Olivera Rajkovic-Hooley
Publikováno v:
Blood. 138:3106-3106
Introduction: The Sickle Cell World Assessment Survey (SWAY) was a cross-sectional survey to assess the global impact and treatment of sickle cell disease (SCD). Complications of SCD can lead to significant negative effects on patient (pt) quality of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::924bc2de5d440065d241908f7a9912d7
https://doi.org/10.1182/blood-2021-146566
https://doi.org/10.1182/blood-2021-146566