Zobrazeno 1 - 10
of 223
pro vyhledávání: '"John R Huguenard"'
Publikováno v:
eLife, Vol 12 (2023)
Absence seizures are characterized by brief periods of unconsciousness accompanied by lapses in motor function that can occur hundreds of times throughout the day. Outside of these frequent moments of unconsciousness, approximately a third of people
Externí odkaz:
https://doaj.org/article/6745b689eadc45038fab0b15a37321ab
Autor:
Adam C Lu, Christine Kyuyoung Lee, Max Kleiman-Weiner, Brian Truong, Megan Wang, John R Huguenard, Mark P Beenhakker
Publikováno v:
eLife, Vol 9 (2020)
Absence seizures result from 3 to 5 Hz generalized thalamocortical oscillations that depend on highly regulated inhibitory neurotransmission in the thalamus. Efficient reuptake of the inhibitory neurotransmitter GABA is essential, and reuptake failur
Externí odkaz:
https://doaj.org/article/7bb2585d9c144c818735039d3968115b
Autor:
P Michelle Fogerson, John R Huguenard
Publikováno v:
eLife, Vol 5 (2016)
Temporary circuits amplify spontaneous activity in the visual system of neonatal rats.
Externí odkaz:
https://doaj.org/article/26c2007b511e4b69859e7905441d6315
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85865 (2014)
Reciprocal inhibition between inhibitory projection neurons has been proposed as the most efficient circuit motif to achieve the flexible selection of one stimulus among competing alternatives. However, whether such a motif exists in networks that me
Externí odkaz:
https://doaj.org/article/7963e7dbed0a4551892fc2a32e864635
Autor:
Frédéric Manseau, Silvia Marinelli, Pablo Méndez, Beat Schwaller, David A Prince, John R Huguenard, Alberto Bacci
Publikováno v:
PLoS Biology, Vol 8, Iss 9 (2010)
Networks of specific inhibitory interneurons regulate principal cell firing in several forms of neocortical activity. Fast-spiking (FS) interneurons are potently self-inhibited by GABAergic autaptic transmission, allowing them to precisely control th
Externí odkaz:
https://doaj.org/article/69db227121454a2592d978dd843253ad
Autor:
Omer Revah, Felicity Gore, Kevin W. Kelley, Jimena Andersen, Noriaki Sakai, Xiaoyu Chen, Min-Yin Li, Fikri Birey, Xiao Yang, Nay L. Saw, Samuel W. Baker, Neal D. Amin, Shravanti Kulkarni, Rachana Mudipalli, Bianxiao Cui, Seiji Nishino, Gerald A. Grant, Juliet K. Knowles, Mehrdad Shamloo, John R. Huguenard, Karl Deisseroth, Sergiu P. Pașca
Publikováno v:
Nature. 610:319-326
Self-organizing neural organoids represent a promising in vitro platform with which to model human development and disease1–5. However, organoids lack the connectivity that exists in vivo, which limits maturation and makes integration with other ci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3b1007a8fb5f6835b7af22c47b561a
https://doi.org/10.1038/s41586-022-05277-w
https://doi.org/10.1038/s41586-022-05277-w
Autor:
Juliet K. Knowles, Haojun Xu, Caroline Soane, Ankita Batra, Tristan Saucedo, Eleanor Frost, Lydia T. Tam, Danielle Fraga, Lijun Ni, Katlin Villar, Sydney Talmi, John R. Huguenard, Michelle Monje
Publikováno v:
Nature Neuroscience. 25:596-606
Activity-dependent myelination can fine-tune neural network dynamics. Conversely, aberrant neuronal activity, as occurs in disorders of recurrent seizures (epilepsy), could promote maladaptive myelination, contributing to pathogenesis. In this study,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19b3d707a7c3329a40c198fc4c78b4f
https://doi.org/10.1038/s41593-022-01052-2
https://doi.org/10.1038/s41593-022-01052-2
Autor:
Ya-Ting Chang, Max Kowalczyk, P. Michelle Fogerson, Yu-Ju Lee, Minza Haque, Eliza L. Adams, David C. Wang, Laura A. DeNardo, Marc Tessier-Lavigne, John R. Huguenard, Liqun Luo, Wei-Hsiang Huang
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Hyperexcitability of brain circuits is a common feature of autism spectrum disorders (ASDs). Genetic deletion of a chromatin-binding protein, retinoic acid induced 1 ( RAI1 ), causes Smith–Magenis syndrome (SMS). SMS is a syndromic ASD associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dcfc4e55af1947fc692f5b35bf583331
https://doi.org/10.1073/pnas.2210122119
https://doi.org/10.1073/pnas.2210122119