Zobrazeno 1 - 10
of 182
pro vyhledávání: '"John R Horton"'
Autor:
Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Publikováno v:
PLoS Biology, Vol 16, Iss 8, p e2006134 (2018)
Cyclic GMP-AMP (cGAMP) synthase (cGAS) stimulator of interferon genes (STING) senses pathogen-derived or abnormal self-DNA in the cytosol and triggers an innate immune defense against microbial infection and cancer. STING agonists induce both innate
Externí odkaz:
https://doaj.org/article/b82bd2d7d5a04000a7a64e580355ce3f
Autor:
Neela D Goswami, Christopher D Pfeiffer, John R Horton, Karen Chiswell, Asba Tasneem, Ephraim L Tsalik
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77086 (2013)
There is a paucity of clinical trials informing specific questions faced by infectious diseases (ID) specialists. The ClinicalTrials.gov registry offers an opportunity to evaluate the ID clinical trials portfolio.We examined 40,970 interventional tri
Externí odkaz:
https://doaj.org/article/587df151f10e43cc8d498c43c2e7b7ec
Autor:
M Mitsu Suyemoto, Terri S Hamrick, Patricia A Spears, John R Horton, Ida M Washington, Edward A Havell, Luke B Borst, Paul E Orndorff
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72601 (2013)
Gravid mice and other rodents inoculated with Listeria monocytogenes typically fail to clear an intrauterine infection and either succumb or expel their intrauterine contents. We took advantage of this property to investigate the effects of an extrau
Externí odkaz:
https://doaj.org/article/74b0695f6bc8405cb07258e86269635f
Autor:
Jujun Zhou, John R. Horton, Dan Yu, Ren Ren, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng
Publikováno v:
Epigenetics, Vol 17, Iss 9, Pp 970-981 (2022)
Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited
Externí odkaz:
https://doaj.org/article/5a7bb73e66d04b97acf84d95ef8faf4c
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Clostridioides difficile adenine methyltransferase A (CamA) is required for the sporulation and colonization of the pathogen that causes gastrointestinal infections. Here, the authors characterise CamA kinetically and present its crystal structure bo
Externí odkaz:
https://doaj.org/article/72d81f7c9e58495889a373df8da8fa71
Publikováno v:
Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Background Studies suggest that acute decreases in lung hyperinflation at rest improves cardiac function and increases lung vascular perfusion from decompression of a compromised heart. In those studies, changes in resting oxygen uptake indu
Externí odkaz:
https://doaj.org/article/01eb242c83bb451aa90eed699ed5e969
Autor:
John R. Horton, Clayton B. Woodcock, Sifa B. Opot, Norbert O. Reich, Xing Zhang, Xiaodong Cheng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
CcrM is a cell cycle-regulated DNA methyltransferase that methylates an adenine within a specific sequence following replication in the gram negative bacterium Caulobacter crescentus. Here the authors present a crystal structure of DNA-bound CcrM tha
Externí odkaz:
https://doaj.org/article/4b19d54306f64a6a987f9f163c1d7c87
Autor:
Yang Yang, Ren Ren, Lana C. Ly, John R. Horton, Fudong Li, Kate G.R. Quinlan, Merlin Crossley, Yunyu Shi, Xiaodong Cheng
Publikováno v:
Cell Reports, Vol 36, Iss 13, Pp 109759- (2021)
Summary: Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF, bind directly to the fetal globin promoter elements positioned at
Externí odkaz:
https://doaj.org/article/278a9d06804e4cee8c530abe483c04e3
Autor:
Shaobo Dai, John R. Horton, Clayton B. Woodcock, Alex W. Wilkinson, Xing Zhang, Or Gozani, Xiaodong Cheng
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.
Externí odkaz:
https://doaj.org/article/f2129526184a4597af28ea92c757a4b4
Autor:
Jujun Zhou, Youchao Deng, Iredia D. Iyamu, John R. Horton, Dan Yu, Taraneh Hajian, Masoud Vedadi, Dante Rotili, Antonello Mai, Robert M. Blumenthal, Xing Zhang, Rong Huang, Xiaodong Cheng
Publikováno v:
ACS Chemical Biology. 18:734-745