Zobrazeno 1 - 10
of 75
pro vyhledávání: '"John R Hadcock"'
Autor:
Susana S. Correia, Guang Liu, Sarah Jacobson, Sylvie G. Bernier, Jenny V. Tobin, Chad D. Schwartzkopf, Emily Atwater, Elisabeth Lonie, Sam Rivers, Andrew Carvalho, Peter Germano, Kim Tang, Rajesh R. Iyengar, Mark G. Currie, John R. Hadcock, Christopher J. Winrow, Juli E. Jones
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating n
Externí odkaz:
https://doaj.org/article/b9dc10997df94c7186de03737efe4dd1
Autor:
Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Peter Germano, Julien Roux, Courtney M. Shea, Emmanuel S. Buys, Juli E. Jones
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Praliciguat is a soluble guanylate cyclase stimulator that elicits hemodynamic, anti-inflammatory, and antifibrotic effects in preclinical models of metabolic dysfunction. We assessed the metabolic effects of praliciguat in a mouse diet-induced obesi
Externí odkaz:
https://doaj.org/article/276425e92d2143c0a1202416a49b9492
Autor:
Susana S. Correia, Rajesh R. Iyengar, Peter Germano, Kim Tang, Sylvie G. Bernier, Chad D. Schwartzkopf, Jenny Tobin, Thomas W.-H. Lee, Guang Liu, Sarah Jacobson, Andrew Carvalho, Glen R. Rennie, Joon Jung, Paul A. Renhowe, Elisabeth Lonie, Christopher J. Winrow, John R. Hadcock, Juli E. Jones, Mark G. Currie
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclas
Externí odkaz:
https://doaj.org/article/77b2ed6c8b9c4de4b87274d76d632880
Autor:
Juli E. Jones, Samuel M. Cadena, Chenguang Gong, Xiaomei Wang, Zhiping Chen, Sharon X. Wang, Chad Vickers, Hong Chen, Estelle Lach-Trifilieff, John R. Hadcock, David J. Glass
Publikováno v:
Cell Reports, Vol 22, Iss 6, Pp 1522-1530 (2018)
Summary: The age-related effects of GDF11 have been a subject of controversy. Here, we find that elevated GDF11 causes signs of cachexia in mice: reduced food intake, body weight, and muscle mass. GDF11 also elicited a significant elevation in plasma
Externí odkaz:
https://doaj.org/article/de796d96192e4bc598fb869ac2400859
Autor:
Samantha Foley, Shawn Harriman, Jianbo Zhang, Marie Claire Mukashyaka, Bryan Mastis, John R Hadcock, Jenna Wood, Chia-Ling Wu, Nino Jungels, Kristin Ha, Mohammad Shadid, Huadong Sun
Publikováno v:
Pharmaceutical Research
Purpose Peptide-conjugated phosphorodiamidate morpholino oligomers (PPMOs) have shown promise in treating Duchenne muscular dystrophy (DMD). We evaluated a semi-mechanistic pharmacokinetic (PK) and pharmacodynamic (PD) model to capture the relationsh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd3050837b15b9860574fc3a20a025d
https://doi.org/10.1007/s11095-021-03118-5
https://doi.org/10.1007/s11095-021-03118-5
Autor:
Jangir Selimkhanov, W Clayton Thompson, Terrell A Patterson, John R Hadcock, Dennis O Scott, Tristan S Maurer, Cynthia J Musante
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0155674 (2016)
The purpose of this work is to develop a mathematical model of energy balance and body weight regulation that can predict species-specific response to common pre-clinical interventions. To this end, we evaluate the ability of a previously published m
Externí odkaz:
https://doaj.org/article/b8265b1953804725b8d28146b34ee9e1
Autor:
Sylvie G. Bernier, Peter Germano, Christopher J. Winrow, Chad D. Schwartzkopf, Susana S. Correia, Kim Tang, Juli E. Jones, Sam Rivers, Elisabeth Lonie, Guang Liu, Sarah Jacobson, Andrew Carvalho, Jenny Tobin, John R. Hadcock, Emily Atwater, Rajesh R. Iyengar, Mark G. Currie
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-13 (2021)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinfla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199a830a1937f260ccf762e3f641c144
https://doi.org/10.1186/s12974-021-02275-z
https://doi.org/10.1186/s12974-021-02275-z
Autor:
Andrew Carvalho, Kim Tang, Christopher J. Winrow, John R. Hadcock, Sarah Jacobson, Jenny Tobin, Elisabeth Lonie, Sylvie G. Bernier, Thomas W.-H. Lee, Susana S. Correia, Rennie Glen Robert, Chad D. Schwartzkopf, Joon Jung, Peter Germano, Guang Liu, Juli E. Jones, Mark G. Currie, Paul Allan Renhowe, Rajesh R. Iyengar
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Effective treatments for neurodegenerative diseases remain elusive and are critically needed since the burden of these diseases increases across an aging global population. Nitric oxide (NO) is a gasotransmitter that binds to soluble guanylate cyclas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f32016c7ebcec298b36c97328d53b8a4
https://www.frontiersin.org/articles/10.3389/fphar.2021.656561/full
https://www.frontiersin.org/articles/10.3389/fphar.2021.656561/full
Publikováno v:
Diabetes. 69
Background: Praliciguat (IW-1973) is an sGC stimulator in clinical development as a potential treatment for diabetic kidney disease. In animal models, praliciguat distributes broadly to tissues and elicits hemodynamic, anti-inflammatory, anti-fibroti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ba9de97f4ff65247388bb7f43837aa0
https://doi.org/10.2337/db20-124-lb
https://doi.org/10.2337/db20-124-lb
Autor:
Chad D. Schwartzkopf, John R. Hadcock, Guang Liu, Juli E. Jones, Mark G. Currie, Jamie L Masferrer
Publikováno v:
Journal of the Endocrine Society
Praliciguat (PRL) is a soluble guanylate cyclase (sGC) stimulator which in animal models distributes broadly to tissues and elicits hemodynamic, anti-inflammatory, anti-fibrotic, and metabolic effects. Here, we assessed metabolic effects of PRL in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf4362cd8e74047c72faaaf736c6fa8
https://doi.org/10.1210/jendso/bvaa046.917
https://doi.org/10.1210/jendso/bvaa046.917