Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John R Ferrarone"'
Autor:
Arun M Unni, Bryant Harbourne, Min Hee Oh, Sophia Wild, John R Ferrarone, William W Lockwood, Harold Varmus
Publikováno v:
eLife, Vol 7 (2018)
Synthetic lethality results when mutant KRAS and EGFR proteins are co-expressed in human lung adenocarcinoma (LUAD) cells, revealing the biological basis for mutual exclusivity of KRAS and EGFR mutations. We have now defined the biochemical events re
Externí odkaz:
https://doaj.org/article/c9a152b7e5fb4105b4de838a7f359c26
Autor:
Benjamin D. Stein, John R. Ferrarone, Eric E. Gardner, Jae Won Chang, David Wu, Pablo E. Hollstein, Roger J. Liang, Min Yuan, Qiuying Chen, John S. Coukos, Miriam Sindelar, Bryan Ngo, Steven S. Gross, Reuben J. Shaw, Chen Zhang, John M. Asara, Raymond E. Moellering, Harold Varmus, Lewis C. Cantley
Publikováno v:
Cancer Discovery. 13:1002-1025
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ac5f4cb166033aae485e34312737576
https://doi.org/10.1158/2159-8290.cd-22-0805
https://doi.org/10.1158/2159-8290.cd-22-0805
Autor:
Lewis C. Cantley, Harold Varmus, Raymond E. Moellering, John M. Asara, Chen Zhang, Reuben J. Shaw, Steven S. Gross, Bryan Ngo, Miriam Sindelar, John S. Coukos, Qiuying Chen, Min Yuan, Roger J. Liang, Pablo E. Hollstein, David Wu, Jae Won Chang, Eric E. Gardner, John R. Ferrarone, Benjamin D. Stein
Figure S3. TPI1 phosphorylation regulates triose phosphate levels and metabolic flux.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e442f21632c30fbcd19a65b226840d4
https://doi.org/10.1158/2159-8290.22553386
https://doi.org/10.1158/2159-8290.22553386
Autor:
Lewis C. Cantley, Harold Varmus, Raymond E. Moellering, John M. Asara, Chen Zhang, Reuben J. Shaw, Steven S. Gross, Bryan Ngo, Miriam Sindelar, John S. Coukos, Qiuying Chen, Min Yuan, Roger J. Liang, Pablo E. Hollstein, David Wu, Jae Won Chang, Eric E. Gardner, John R. Ferrarone, Benjamin D. Stein
KRAS is the most frequently mutated oncogene in human lung adenocarcinomas (hLUAD), and activating mutations frequently co-occur with loss-of-function mutations in TP53 or STK11/LKB1. However, mutation of all three genes is rarely observed in hLUAD,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a4888ce7db00a4ab236f555bdd0a96
https://doi.org/10.1158/2159-8290.c.6534613.v2
https://doi.org/10.1158/2159-8290.c.6534613.v2
Autor:
Colin P. Tang, Owen Clark, John R. Ferrarone, Carl Campos, Alshad S. Lalani, John D. Chodera, Andrew M. Intlekofer, Olivier Elemento, Ingo K. Mellinghoff
Publikováno v:
Nat Chem Biol
Small-molecule kinase inhibitors represent a major group of cancer therapeutics, but tumor responses are often incomplete. To identify pathways that modulate kinase inhibitor response, we conducted a genome-wide knockout (KO) screen in glioblastoma c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::353772edab7f26f780c5777a78c48e8c
https://europepmc.org/articles/PMC9549920/
https://europepmc.org/articles/PMC9549920/