Zobrazeno 1 - 10
of 1 002
pro vyhledávání: '"John R Falck"'
Autor:
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0169584 (2017)
Cytochromes P450 metabolize arachidonic acid (AA) into two vasoactive oxylipins with opposing biologic effects: epoxyeicosatrienoic acids (EETs) and omega-(ω)-terminal hydroxyeicosatetraenoic acids (HETEs). EETs have numerous beneficial physiologica
Externí odkaz:
https://doaj.org/article/1ff191981bec4ebc9304a069091d05c6
Autor:
Ahmad Hanif, Matthew L Edin, Darryl C Zeldin, Christophe Morisseau, John R Falck, Mohammed A Nayeem
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0174137 (2017)
Arachidonic acid is metabolized to epoxyeicosatrienoic acids (EETs) by cytochrome (CYP) P450 epoxygenases, and to ω-terminal hydroxyeicosatetraenoic acids (HETEs) by ω-hydroxylases. EETs and HETEs often have opposite biologic effects; EETs are vaso
Externí odkaz:
https://doaj.org/article/b6bcfffffb58418e90b7ef28c1b690c7
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160380 (2016)
Maintenance of a healthy pool of mitochondria is important for the function and survival of terminally differentiated cells such as cardiomyocytes. Epoxyeicosatrienoic acids (EETs) are epoxy lipids derived from metabolism of arachidonic acid by cytoc
Externí odkaz:
https://doaj.org/article/aabb9c9844784ea297dec290179ccd7d
Autor:
Victor eSamokhvalov, Jelle eVriend, Kristi L Jamieson, Maria eAkhnokh, Rajkumar eManne, John R Falck, John M. Seubert
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Lipopolysaccharide (LPS) is a bacterial wall endotoxin producing many pathophysiological conditions including myocardial inflammation leading to cardiotoxicity. Epoxyeicosatrienoic acids (EETs) are biologically active metabolites of arachidonic acids
Externí odkaz:
https://doaj.org/article/3fb0cba51f004916862b4f8934c1d9be
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Epoxyeicosatrienoic acids (EETs) contribute to blood pressure regulation leading to the concept that EETs can be therapeutically targeted for hypertension and the associated end-organ damage. In the present study, we investigated anti-hypertensive an
Externí odkaz:
https://doaj.org/article/08b7bd77628742b5bdcc3dad55ca4790
Autor:
Christina Westphal, Bastian Spallek, Anne Konkel, Lajos Marko, Fatimunnisa Qadri, Laura M DeGraff, Carola Schubert, J Alyce Bradbury, Vera Regitz-Zagrosek, John R Falck, Darryl C Zeldin, Dominik N Müller, Wolf-Hagen Schunck, Robert Fischer
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e73490 (2013)
Maladaptive cardiac hypertrophy predisposes one to arrhythmia and sudden death. Cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) promote anti-inflammatory and antiapoptotic mechanisms, and are involved in the regulation of cardiac Ca(2+
Externí odkaz:
https://doaj.org/article/15f5ebcb62324071b24fae2120c37b4b
Autor:
Fan Fan, Cheng-Wen Sun, Kristopher G Maier, Jan M Williams, Malikarjuna R Pabbidi, Sean P Didion, John R Falck, Jialong Zhuo, Richard J Roman
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82482 (2013)
The present study examined whether 20-hydroxyeicosatetraenoic acid (HETE) contributes to the vasoconstrictor effect of angiotensin II (ANG II) in renal microvessels by preventing activation of the large conductance Ca(2+)-activated K(+) channel (KCa)
Externí odkaz:
https://doaj.org/article/6632f31c961c4c898659b73d9389f703
Autor:
John D Imig, Ahmed eElmarakby, Kasem eNithipatikom, Shouzou eWei, Jorge H Capdevila, Venugopal R Tuniki, Bhavani eSangras, Siddam eAnjaiah, Vijaya L Manthati, D. Sudarashan Reddy, John R Falck
Publikováno v:
Frontiers in Physiology, Vol 1 (2010)
Epoxyeicosatrienoic acids (EETs) contribute importantly to the regulation of vascular tone and blood pressure control. The purpose of this study was to develop stable EET analogs and test their in vivo blood pressure lowering effects in hypertensive
Externí odkaz:
https://doaj.org/article/b3ad7da4ab0b4927ae4676009e3a8107
Autor:
Ambra Pozzi, Scott M. Williams, F. Peter Guengerich, John R. Falck, Jorge H. Capdevila, Megan M. Shuey, James M. Luther, Roy Zent, Shouzuo Wei, Shaojun Mei, Manuel Chiusa, Mahesha H. Gangadhariah, Lindsay N. Sausville
This file contains the primer sequence of CYP2C9* variants (Supplementary Table S1); the SNPs genotyped in the BioVU NSCLC study (Supplementary Table S2); quality control measures of SNPs in the BioVU NSCLC study (Supplementary Table S3); clinical an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::308f7412116c1324a40a6f5c93f46538
https://doi.org/10.1158/0008-5472.22426270.v1
https://doi.org/10.1158/0008-5472.22426270.v1
Autor:
Ambra Pozzi, Scott M. Williams, F. Peter Guengerich, John R. Falck, Jorge H. Capdevila, Megan M. Shuey, James M. Luther, Roy Zent, Shouzuo Wei, Shaojun Mei, Manuel Chiusa, Mahesha H. Gangadhariah, Lindsay N. Sausville
Increased expression of cytochrome P450 CYP2C9, together with elevated levels of its products epoxyeicosatrienoic acids (EET), is associated with aggressiveness in cancer. Cytochrome P450 variants CYP2C9*2 and CYP2C9*3 encode proteins with reduced en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ff77c3335eea0c969f51ecdd1f48097
https://doi.org/10.1158/0008-5472.c.6512281
https://doi.org/10.1158/0008-5472.c.6512281