Zobrazeno 1 - 10
of 183
pro vyhledávání: '"John R Edwards"'
Autor:
Antonietta Franco, Jiajia Li, Daniel P Kelly, Ray E Hershberger, Ali J Marian, Renate M Lewis, Moshi Song, Xiawei Dang, Alina D Schmidt, Mary E Mathyer, John R Edwards, Cristina de Guzman Strong, Gerald W Dorn
Publikováno v:
eLife, Vol 12 (2023)
Cardiac muscle has the highest mitochondrial density of any human tissue, but mitochondrial dysfunction is not a recognized cause of isolated cardiomyopathy. Here, we determined that the rare mitofusin (MFN) 2 R400Q mutation is 15–20× over-represe
Externí odkaz:
https://doaj.org/article/c8163fadb630467b8faefb631505c99f
Autor:
Xiaogang Cheng, Ancy Joseph, Victor Castro, Alice Chen-Liaw, Zachary Skidmore, Takaharu Ueno, Jun-Ichi Fujisawa, Daniel A Rauch, Grant A Challen, Michael P Martinez, Patrick Green, Malachi Griffith, Jacqueline E Payton, John R Edwards, Lee Ratner
Publikováno v:
PLoS Pathogens, Vol 17, Iss 5, p e1009577 (2021)
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that causes an aggressive T-cell malignancy and a variety of inflammatory conditions. The integrated provirus includes a single binding site for the epigenomic insulator, CCCTC-binding prote
Externí odkaz:
https://doaj.org/article/9259a77e24be4c85b2f4a38963e76857
Autor:
Srivarsha Rajshekar, Jun Yao, Paige K Arnold, Sara G Payne, Yinwen Zhang, Teresa V Bowman, Robert J Schmitz, John R Edwards, Mary Goll
Publikováno v:
eLife, Vol 7 (2018)
Pericentromeric satellite repeats are enriched in 5-methylcytosine (5mC). Loss of 5mC at these sequences is common in cancer and is a hallmark of Immunodeficiency, Centromere and Facial abnormalities (ICF) syndrome. While the general importance of 5m
Externí odkaz:
https://doaj.org/article/17b088700f0a408984fdd17bfa82fe16
Publikováno v:
Epigenetics & Chromatin, Vol 10, Iss 1, Pp 1-10 (2017)
Abstract The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein
Externí odkaz:
https://doaj.org/article/49017be66fca4553a952b2fbc76f1092
Autor:
Brian A. Jonas, Jing‐Zhou Hou, Gail J. Roboz, Caroline L. Alvares, Deepa Jeyakumar, John R. Edwards, Harry P. Erba, Richard J. Kelly, Christoph Röllig, Walter Fiedler, Deanna Brackman, Satya R. Siddani, Brenda Chyla, Jacqueline Hilger‐Rolfe, Justin M. Watts
Publikováno v:
Hematological Oncology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::077c9fd12e3b9c635ced4046fbc98031
https://doi.org/10.1002/hon.3159
https://doi.org/10.1002/hon.3159
Autor:
Xiaoqing Cheng, Yirui Sun, Maureen Highkin, Nagalaxmi Vemalapally, Xiaohua Jin, Brandon Zhou, Julie L. Prior, Ashley R. Tipton, Shunqiang Li, Anton Iliuk, Samuel Achilefu, Ian S. Hagemann, John R. Edwards, Ron Bose
In metastatic breast cancer, HER2 activating mutations frequently co-occur with mutations in thePIK3CA,TP53, or E-cadherin genes. Of these co-occurring mutations,HER2andPIK3CAmutations are the most prevalent gene pair, with approximately 40% ofHER2mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1331b3ffa44cac2651a53983bb1b024c
https://doi.org/10.1101/2022.11.09.515796
https://doi.org/10.1101/2022.11.09.515796
Autor:
Erica G. Schmitt, Kelsey A. Toth, Samuel I. Risma, Ana Kolicheski, Nermina Saucier, Rafael J. Feliciano Berríos, Zev J. Greenberg, Jennifer W. Leiding, Jack J. Bleesing, Akaluck Thatayatikom, Laura G. Schuettpelz, John R. Edwards, Tiphanie P. Vogel, Megan A. Cooper
Publikováno v:
JCI Insight. 7
Primary immune regulatory disorders (PIRD) represent a group of disorders characterized by immune dysregulation, presenting with a wide range of clinical disease, including autoimmunity, autoinflammation, or lymphoproliferation. Autosomal dominant ge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454faeca7c39fb984c904244efbe1889
https://doi.org/10.1172/jci.insight.162695
https://doi.org/10.1172/jci.insight.162695
Autor:
John R. Edwards, Malcolm Anderson
Publikováno v:
Accounting, Auditing & Accountability Journal, 2011, Vol. 24, Issue 6, pp. 685-717.
Externí odkaz:
http://www.emeraldinsight.com/doi/10.1108/09513571111155519
Autor:
Shunqiang Li, Dong Shen, Jieya Shao, Robert Crowder, Wenbin Liu, Aleix Prat, Xiaping He, Shuying Liu, Jeremy Hoog, Charles Lu, Li Ding, Obi L. Griffith, Christopher Miller, Dave Larson, Robert S. Fulton, Michelle Harrison, Tom Mooney, Joshua F. McMichael, Jingqin Luo, Yu Tao, Rodrigo Goncalves, Christopher Schlosberg, Jeffrey F. Hiken, Laila Saied, Cesar Sanchez, Therese Giuntoli, Caroline Bumb, Crystal Cooper, Robert T. Kitchens, Austin Lin, Chanpheng Phommaly, Sherri R. Davies, Jin Zhang, Megha Shyam Kavuri, Donna McEachern, Yi Yu Dong, Cynthia Ma, Timothy Pluard, Michael Naughton, Ron Bose, Rama Suresh, Reida McDowell, Loren Michel, Rebecca Aft, William Gillanders, Katherine DeSchryver, Richard K. Wilson, Shaomeng Wang, Gordon B. Mills, Ana Gonzalez-Angulo, John R. Edwards, Christopher Maher, Charles M. Perou, Elaine R. Mardis, Matthew J. Ellis
Publikováno v:
Cell Reports, Vol 4, Iss 6, Pp 1116-1130 (2013)
To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retaine
Externí odkaz:
https://doaj.org/article/1caf49e311cd490a9bd70c469f4ea5ca
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Methylated mammalian promoters are transcriptionally silenced by nuclear factors, but the identity of these factors and the molecular mechanism of methylation-induced repression have long been elusive. We show here that methylated promot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19fc438d8f961981eeac295f01fb3e8a
https://doi.org/10.1073/pnas.1912074117
https://doi.org/10.1073/pnas.1912074117